Aadac | GeneID:57300 | Rattus norvegicus

Gene Summary

[ ] NCBI Entrez Gene

Gene ID	57300	Official Symbol	Aadac
Locus	N/A	Gene Type	protein-coding
Synonyms	Aada
Full Name	arylacetamide deacetylase (esterase)
Description	arylacetamide deacetylase (esterase)
Chromosome	2q31
Also Known As	arylacetamide deacetylase
Summary	N/A

Orthologs and Paralogs

[ ] Homologs - NCBI's HomoloGene Group: 37436

ID	Symbol	Protein	Species
GeneID:13	AADAC	NP_001077.2	Homo sapiens
GeneID:57300	Aadac	NP_065413.1	Rattus norvegicus
GeneID:67758	Aadac	NP_075872.1	Mus musculus
GeneID:425034	AADACL2	XP_422836.2	Gallus gallus
GeneID:460785	AADAC	XP_001145851.1	Pan troglodytes
GeneID:477115	AADAC	XP_534309.2	Canis lupus familiaris
GeneID:519557	AADAC	NP_001069259.1	Bos taurus
GeneID:100148912	LOC100148912	XP_001923714.1	Danio rerio

Gene Classification

[ ] Gene Ontology

ID	Category	GO Term
GO:0005737	Component	cytoplasm
GO:0005783	Component	endoplasmic reticulum
GO:0005789	Component	endoplasmic reticulum membrane
GO:0016021	Component	integral to membrane
GO:0016020	Component	membrane
GO:0005792	Component	microsome
GO:0004091	Function	carboxylesterase activity
GO:0019213	Function	deacetylase activity
GO:0006629	Process	lipid metabolic process
GO:0008152	Process	metabolic process

RefSeq Isoforms

[ ] RefSeq Annotation and UniProt Database

No.	RefSeq RNA	RefSeq Protein	UniProt Equivalent
1	NM_020538 UCSC Browser	NP_065413

MicroRNA and Targets

[ ] MicroRNA Sequences and Transcript Targets from miRBase at Sanger

RNA Target	miRNA #	mat miRNA	Mature miRNA Sequence
ENSRNOT00000018761	MI0003144	hsa-miR-515-3p	GAGUGCCUUCUUUUGGAGCGUU
ENSRNOT00000018761	MI0003147	hsa-miR-515-3p	GAGUGCCUUCUUUUGGAGCGUU
ENSRNOT00000018761	MI0003178	hsa-miR-519a	AAAGUGCAUCCUUUUAGAGUGU
ENSRNOT00000018761	MI0003182	hsa-miR-519a	AAAGUGCAUCCUUUUAGAGUGU
ENSRNOT00000018761	MI0003151	hsa-miR-519b-3p	AAAGUGCAUCCUUUUAGAGGUU
ENSRNOT00000018761	MI0003148	hsa-miR-519c-3p	AAAGUGCAUCUUUUUAGAGGAU
ENSRNOT00000018761	MI0003162	hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUG
ENSRNOT00000018761	MI0003145	hsa-miR-519e	AAGUGCCUCCUUUUAGAGUGUU
ENSRNOT00000018761	MI0003155	hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
ENSRNOT00000018761	MI0003158	hsa-miR-520c-3p	AAAGUGCUUCCUUUUAGAGGGU
ENSRNOT00000018761	MI0003143	hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
ENSRNOT00000018761	MI0003612	hsa-miR-548a-5p	AAAAGUAAUUGCGAGUUUUACC
ENSRNOT00000018761	MI0003668	hsa-miR-548d-5p	AAAAGUAAUUGUGGUUUUUGCC
ENSRNOT00000018761	MI0003671	hsa-miR-548d-5p	AAAAGUAAUUGUGGUUUUUGCC
ENSRNOT00000018761	MI0003583	hsa-miR-576-3p	AAGAUGUGGAAAAAUUGGAAUC
ENSRNOT00000018761	MI0003641	hsa-miR-627	GUGAGUCUCUAAGAAAAGAGGA
ENSRNOT00000018761	MI0003642	hsa-miR-628-3p	UCUAGUAAGAGUGGCAGUCGA
ENSRNOT00000018761	MI0003648	hsa-miR-633	CUAAUAGUAUCUACCACAAUAAA
ENSRNOT00000018761	MI0003666	hsa-miR-651	UUUAGGAUAAGCUUGACUUUUG
ENSRNOT00000018761	MI0003834	hsa-miR-769-5p	UGAGACCUCUGGGUUCUGAGCU
ENSRNOT00000018761	MI0002402	mmu-miR-467a	UAAGUGCCUGCAUGUAUAUGCG
ENSRNOT00000018761	MI0005513	mmu-miR-467d	UAAGUGCGCGCAUGUAUAUGCG
ENSRNOT00000018761	MI0006128	mmu-miR-467e	AUAAGUGUGAGCAUGUAUAUGU
ENSRNOT00000018761	MI0005518	mmu-miR-574-5p	UGAGUGUGUGUGUGUGAGUGUGU
ENSRNOT00000018761	MI0005519	mmu-miR-590-5p	GAGCUUAUUCAUAAAAGUGCAG
ENSRNOT00000018761	MI0004666	mmu-miR-669b	AGUUUUGUGUGCAUGUGCAUGU
ENSRNOT00000018761	MI0005204	mmu-miR-805	GAAUUGAUCAGGACAUAGGG
ENSRNOT00000018761	MI0000886	rno-miR-101a	UACAGUACUGUGAUAACUGAA
ENSRNOT00000018761	MI0000648	rno-miR-101b	UACAGUACUGUGAUAGCUGAA
ENSRNOT00000018761	MI0000889	rno-miR-106b	UAAAGUGCUGACAGUGCAGAU
ENSRNOT00000018761	MI0000616	rno-miR-148b-3p	UCAGUGCAUCACAGAACUUUGU
ENSRNOT00000018761	MI0000921	rno-miR-152	UCAGUGCAUGACAGAACUUGG
ENSRNOT00000018761	MI0006131	rno-miR-17	CAAAGUGCUUACAGUGCAGGUAG
ENSRNOT00000018761	MI0000638	rno-miR-20a	UAAAGUGCUUAUAGUGCAGGUAG
ENSRNOT00000018761	MI0003554	rno-miR-20b-5p	CAAAGUGCUCAUAGUGCAGGU
ENSRNOT00000018761	MI0000960	rno-miR-219-2-3p	AGAAUUGUGGCUGGACAUCUGU
ENSRNOT00000018761	MI0000959	rno-miR-219-5p	UGAUUGUCCAAACGCAAUUCU
ENSRNOT00000018761	MI0000960	rno-miR-219-5p	UGAUUGUCCAAACGCAAUUCU
ENSRNOT00000018761	MI0000963	rno-miR-223	UGUCAGUUUGUCAAAUACCCC
ENSRNOT00000018761	MI0000861	rno-miR-28*	CACUAGAUUGUGAGCUCCUGGA
ENSRNOT00000018761	MI0000965	rno-miR-291a-3p	AAAGUGCUUCCACUUUGUGUGCC
ENSRNOT00000018761	MI0003552	rno-miR-374	AUAUAAUACAACCUGCUAAGUG
ENSRNOT00000018761	MI0001731	rno-miR-451	AAACCGUUACCAUUACUGAGUU
ENSRNOT00000018761	MI0006160	rno-miR-708	AAGGAGCUUACAAUCUAGCUGGG
ENSRNOT00000018761	MI0000641	rno-miR-7a*	ACAACAAAUCACAGUCUGCCAU
ENSRNOT00000018761	MI0000880	rno-miR-93	CAAAGUGCUGUUCGUGCAGGUAG

Transcript Sequences

[ ] Transcript Accession Number Cloud [ GenBank ]

AF182426 BC088143 NM_020538

Protein Sequences

[ ] Protein Accession Number Cloud [ GenPept ]

AAD56394 AAF74757 AAH88143 EDM14838 EDM14839 NP_065413 Q5I0N0 Q9QZH8

Transcript Cluster

Selected Publications

[ ] Gene-related publications indexed at PubMed

[ ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932

The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov).

[ ] Trickett JI, et al. (2001) "Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation." J Biol Chem. 276(43):39522-39532. PMID:11481320

In the current study, we have determined the cDNA and the genomic sequences of the arylacetamide deacetylase (AADA) gene in mice and rats. The AADA genes in the rat and mouse consist of five exons and have 2.4 kilobases of homologous promoter sequence upstream of the initiating ATG codon. AADA mRNA is expressed in hepatocytes, intestinal mucosal cells (probably enterocytes), the pancreas and also the adrenal gland. In mice, there is a diurnal rhythm in hepatic AADA mRNA concentration, with a maximum 10 h into the light (post-absorptive) phase. This diurnal regulation is attenuated in peroxisome proliferator-activated receptor alpha knockout mice. Intestinal but not hepatic AADA mRNA was increased following oral administration of the fibrate, Wy-14,643. The homology of AADA with hormone-sensitive lipase and the tissue distribution of AADA are consistent with the view that AADA plays a role in promoting the mobilization of lipids from intracellular stores and in the liver for assembling VLDL. This hypothesis is supported by parallel changes in AADA gene expression in animals with insulin-deficient diabetes and following treatment with orotic acid.