ABCC1 | GeneID:4363 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 4363 Official Symbol ABCC1
Locus N/A Gene Type protein-coding
Synonyms ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP; MRP1
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Chromosome 16p13.1
Also Known As ATP-binding cassette, sub-family C, member 1; LTC4 transporter; OTTHUMP00000045904; leukotriene C(4) transporter; multidrug resistance protein; multiple drug resistance protein 1; multiple drug resistance-associated protein
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 55459

ID Symbol Protein Species
GeneID:4363 ABCC1 NP_004987.2 Homo sapiens
GeneID:17250 Abcc1 NP_032602.1 Mus musculus
GeneID:24565 Abcc1 NP_071617.2 Rattus norvegicus
GeneID:34686 MRP NP_995695.1 Drosophila melanogaster
GeneID:180408 mrp-2 NP_508121.1 Caenorhabditis elegans
GeneID:180409 mrp-1 NP_001033553.1 Caenorhabditis elegans
GeneID:281588 ABCC1 NP_776648.1 Bos taurus
GeneID:395416 ABCC1 NP_001012540.1 Gallus gallus
GeneID:403453 ABCC1 NP_001002971.1 Canis lupus familiaris
GeneID:453952 ABCC1 XP_001145351.1 Pan troglodytes
GeneID:839277 ATMRP5 NP_171908.1 Arabidopsis thaliana
GeneID:851713 YCF1 NP_010419.1 Saccharomyces cerevisiae
GeneID:1279254 AgaP_AGAP009835 XP_553715.1 Anopheles gambiae
GeneID:2540937 abc3 NP_595055.1 Schizosaccharomyces pombe
GeneID:2543193 abc2 NP_593943.1 Schizosaccharomyces pombe
GeneID:2679616 MGG_01674 XP_363748.2 Magnaporthe grisea
GeneID:2713263 NCU09012.1 XP_331404.1 Neurospora crassa
GeneID:2895493 KLLA0F20075g XP_455982.1 Kluyveromyces lactis
GeneID:4331585 Os03g0142800 NP_001048934.1 Oryza sativa
GeneID:4623012 AGOS_AGR047W NP_986712.1 Eremothecium gossypii
GeneID:100002010 LOC100002010 XP_001341895.2 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab3368 MRP1 antibody [MRPr1] (ab3368); Rat monoclonal [MRPr1] to MRP1
2 abcam ab24102 MRP1 antibody [MRPm5] (ab24102); Mouse monoclonal [MRPm5] to MRP1
3 abcam ab3371 MRP1 antibody [MRPm6] (ab3371); Mouse monoclonal [MRPm6] to MRP1
4 abcam ab3369 MRP1 antibody [QCRL1] (ab3369); Mouse monoclonal [QCRL1] to MRP1
5 abcam ab32574 MRP1 antibody [IU2H10] (ab32574); Mouse monoclonal [IU2H10] to MRP1
6 abnova H00004363-M01 ABCC1 monoclonal antibody (M01), clone 1G8; Mouse monoclonal antibody raised against a partial recombinant ABCC1.
7 scbt ABCC1 ABCC1 Antibody / ABCC1 Antibodies;

Exon, Intron and UTRs

Exon, Intron and UTRs of ABCC1 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ABCC1 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005887 Component integral to plasma membrane
GO:0016020 Component membrane
GO:0005624 Component membrane fraction
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0000166 Function nucleotide binding
GO:0005215 Function transporter activity
GO:0042493 Process response to drug
GO:0006810 Process transport

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_004996  UCSC Browser NP_004987
2 NM_019862  UCSC Browser NP_063915
3 NM_019898  UCSC Browser NP_063953
4 NM_019899  UCSC Browser NP_063954
5 NM_019900  UCSC Browser NP_063955

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
15-deoxy-delta(12,14)-prostaglandin J2
  • ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
14979731
2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid
  • 2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid binds to and results in decreased activity of ABCC1 protein
15623154
2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein
  • 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein
  • alpha-viniferin inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • epsilon-viniferin inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • resveratrol does not affect the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • rhapontin does not affect the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
16827148
2-Acetylaminofluorene
  • 2-Acetylaminofluorene results in increased expression of ABCC1 mRNA
17669244, 12801967
2-butenal
  • 2-butenal does not affect the activity of ABCC1 protein
15885658
2-tert-butylhydroquinone
  • 2-tert-butylhydroquinone results in increased expression of ABCC1 mRNA
16014739
2-tert-butylhydroquinone
  • 2-tert-butylhydroquinone results in increased expression of ABCC1 mRNA
  • 2-tert-butylhydroquinone results in increased expression of ABCC1 protein
11836020
3,3',4,5'-tetrahydroxystilbene
  • 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • 3,3',4,5'-tetrahydroxystilbene results in decreased activity of ABCC1 protein
16827148
3',4'-dihydroxyflavone
  • 3',4'-dihydroxyflavone results in decreased activity of ABCC1 protein
15670588
3-methylquercetin
  • 3-methylquercetin results in decreased activity of ABCC1 protein
15670588
4-hydroxy-2-nonenal
  • 4-hydroxy-2-nonenal binds to ABCC1 protein
15672542
4-Nitroquinoline-1-oxide
  • ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog
  • ABCC1 protein does not affect the export of 4-Nitroquinoline-1-oxide
  • Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]
15766272
5,6-dimethylxanthenoneacetic acid
  • ABCC1 protein affects the export of 5,6-dimethylxanthenoneacetic acid metabolite
15784341
5,6-dimethylxanthenoneacetic acid
  • ABCC1 protein affects the transport of 5,6-dimethylxanthenoneacetic acid analog
15282097
5,7,3',4'-tetramethylluteolin
  • 5,7,3',4'-tetramethylluteolin results in decreased activity of ABCC1 protein
15670588
5'-adenylyl (beta,gamma-methylene)diphosphonate
  • [5'-adenylyl (beta,gamma-methylene)diphosphonate binds to ABCC1 protein] does not affect the reaction [Leukotriene C4 binds to ABCC1 protein]
15755910
5-carboxyfluorescein diacetate
  • Cyclosporine inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
  • Indomethacin inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
  • Verapamil inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
16636798
5-carboxyfluorescein diacetate
  • ABCC1 protein affects the export of 5-carboxyfluorescein diacetate
15744065
6-carboxyfluorescein
  • ABCC1 protein results in increased export of 6-carboxyfluorescein
17940500
6-prenylchrysin
  • 6-prenylchrysin does not affect the activity of ABCC1 protein
15930306
8-azidoadenosine 5'-triphosphate
  • ABCC1 protein binds to 8-azidoadenosine 5'-triphosphate
  • Quercetin does not affect the reaction [ABCC1 protein binds to 8-azidoadenosine 5'-triphosphate]
  • Silymarin does not affect the reaction [ABCC1 protein binds to 8-azidoadenosine 5'-triphosphate]
16156793
Acetaminophen
  • Acetaminophen affects the expression of ABCC1 mRNA
17562736
Acetaminophen
  • Acetaminophen results in increased expression of ABCC1 mRNA
15496496
Acetylcysteine
  • Acetylcysteine promotes the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
  • Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]]
15473893
Acrolein
  • Acrolein does not affect the activity of ABCC1 protein
15885658
Adenosine Triphosphate
  • ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate
  • Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
Adenosine Triphosphate
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]
15245331
Adenosine Triphosphate
  • ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate
  • Cyclosporine does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Verapamil does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Vinblastine does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
10856430
Adenosine Triphosphate
  • Adenosine Triphosphate binds to and affects the folding of ABCC1 protein
15838832, 11278000
Adenosine Triphosphate
  • [Adenosine Triphosphate analog binds to ABCC1 protein] does not affect the reaction [Leukotriene C4 binds to ABCC1 protein]
  • [Adenosine Triphosphate binds to ABCC1 protein] inhibits the reaction [Leukotriene C4 binds to ABCC1 protein]
15755910
Adenosine Triphosphate
  • ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]
15459206
Adenosine Triphosphate
  • Adenosine Triphosphate binds to ABCC1 protein
15737336, 15355964
Adenosine Triphosphate
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]
15459206, 15355964
alpha-viniferin
  • alpha-viniferin inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • alpha-viniferin results in decreased activity of ABCC1 protein
16827148
AN 204
  • AN 204 does not affect the expression of ABCC1 mRNA
16051478, 16047355
AN 215
  • AN 215 does not affect the expression of ABCC1 mRNA
16051478
AN 238
  • AN 238 does not affect the expression of ABCC1 mRNA
16047355
Antimony
  • ABCC1 protein results in chemical resistance to Antimony
  • GCLC protein inhibits the reaction [ABCC1 protein results in chemical resistance to Antimony]
11560771
apicidin
  • ABCC1 protein results in chemical resistance to apicidin
16049968
Apigenin
  • Apigenin results in decreased activity of ABCC1 protein
15670588
apple polyphenol extract
  • apple polyphenol extract results in increased expression of ABCC1 mRNA
18351577
Arsenic
  • ABCC1 protein results in increased export of Arsenic
12387749
arsenic acid
  • ABCC1 protein does not affect the transport of [arsenic acid co-treated with Glutathione]
  • ABCC1 protein does not affect the transport of arsenic acid
15161912
arsenite
  • arsenite does not affect the expression of ABCC1 mRNA
  • arsenite does not affect the expression of ABCC1 protein
11836020
arsenite
  • ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]
  • ABCC1 protein does not affect the transport of arsenite
15161912
artesunate
  • ABCC1 protein does not affect the response to chemical artesunate
15878303
avasimibe
  • avasimibe results in increased expression of ABCC1
15333513
baicalein
  • baicalein results in decreased activity of ABCC1 protein
15670588
Benzo(a)pyrene
  • Benzo(a)pyrene does not affect the expression of ABCC1 mRNA
15566942
Bilirubin
  • ABCC1 protein affects the transport of Bilirubin
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin]
  • Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]
  • Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]
  • verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]
15245331
biochanin A
  • biochanin A results in decreased activity of ABCC1 protein
15581599
bis(4-hydroxycinnamoyl)methane
  • bis(4-hydroxycinnamoyl)methane results in decreased activity of ABCC1 protein
15885658
Buthionine Sulfoximine
  • Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]]
15473893
Buthionine Sulfoximine
  • Buthionine Sulfoximine affects the localization of ABCC1 protein mutant form
  • Buthionine Sulfoximine does not affect the localization of ABCC1 protein
15581632
buthionine sulfoximine ethyl ester
  • ABCC1 protein results in chemical sensitivity to buthionine sulfoximine ethyl ester
  • GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in chemical sensitivity to Chlorambucil]
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in chemical sensitivity to Doxorubicin]
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
  • ABCC1 protein results in chemical sensitivity to buthionine sulfoximine ethyl ester
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
12504668
Butyric Acid
  • Butyric Acid does not affect the expression of ABCC1 mRNA
15711177
Cacodylic Acid
  • Cacodylic Acid results in increased expression of ABCC1 mRNA
  • Cacodylic Acid results in increased expression of ABCC1 protein
16436460
Cadmium
  • ABCC1 protein results in chemical resistance to Cadmium
8947035
caffeic acid phenethyl ester
  • caffeic acid phenethyl ester does not affect the activity of ABCC1 protein
  • caffeic acid phenethyl ester metabolite results in decreased activity of ABCC1 protein
15885658
calcein AM
  • ABCC1 protein affects the export of calcein AM
12516967
Carbon Tetrachloride
  • Carbon Tetrachloride results in increased expression of ABCC1 mRNA
17484886, 15496496
Carbon Tetrachloride
  • Carbon Tetrachloride results in increased expression of ABCC1 protein
16177239
Carbon Tetrachloride
  • Carbon Tetrachloride results in increased expression of ABCC1 protein
17544377
Carmustine
  • ABCC1 protein does not affect the response to chemical Carmustine
12653207
Chlorambucil
  • ABCC1 protein results in chemical resistance to Chlorambucil
11115505, 10900222
Chlorambucil
  • ABCC1 protein results in chemical sensitivity to Chlorambucil
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in chemical sensitivity to Chlorambucil]
12504668
Chlorambucil
  • GSTP1 protein promotes the reaction [ABCC1 protein results in chemical resistance to Chlorambucil]
  • [GCLC protein co-treated with GCLM protein] does not affect the reaction [ABCC1 protein results in chemical resistance to Chlorambucil]
10900222
Chlorambucil
  • ABCC1 protein affects the export of Chlorambucil analog
14569069, 11115505
chlorcyclizine
  • ABCC1 protein affects the transport of chlorcyclizine
15666293
Chlorpheniramine
  • ABCC1 protein affects the transport of Chlorpheniramine
15666293
Chlorpropham
  • ABCC1 protein results in chemical resistance to Chlorpropham
12765240
chrysene
  • chrysene does not affect the expression of ABCC1 mRNA
15566942
chrysoeriol
  • chrysoeriol results in decreased activity of ABCC1 protein
15670588
cinnamic aldehyde
  • cinnamic aldehyde does not affect the activity of ABCC1 protein
15885658
Cisplatin
  • ABCC1 mRNA results in chemical resistance to Cisplatin
15448748
Cisplatin
  • ABCC1 affects the chemical susceptibility to Cisplatin
15756446
Cisplatin
  • ABCC1 protein does not affect the response to chemical Cisplatin
15802814
Cisplatin
  • ABCC1 protein results in chemical resistance to Cisplatin
11455017
citral
  • citral does not affect the activity of ABCC1 protein
15885658
Clobetasol
  • Clobetasol results in decreased expression of ABCC1 mRNA
16882163
Clotrimazole
  • Clotrimazole does not affect the expression of ABCC1 mRNA
  • Clotrimazole does not affect the expression of ABCC1 protein
11836020
Colchicine
  • ABCC1 protein results in chemical resistance to Colchicine
  • ABCC1 protein results in chemical resistance to Colchicine
12067707
copper (N-2-hydroxyacetophenone)glycinate
  • copper (N-2-hydroxyacetophenone)glycinate results in decreased expression of ABCC1 protein
17107616, 16289015
copper (N-2-hydroxyacetophenone)glycinate
  • [copper (N-2-hydroxyacetophenone)glycinate results in decreased expression of ABCC1 protein] which results in chemical sensitivity to Doxorubicin
16289015
Curcumin
  • Curcumin results in decreased activity of ABCC1 protein
16021489, 15885658
Curcumin
  • Curcumin does not affect the expression of ABCC1 protein
16021489
curcumin III
  • curcumin III does not affect the expression of ABCC1 protein
  • curcumin III results in decreased activity of ABCC1 protein
16021489
Cyclophosphamide
  • ABCC1 protein affects the chemical susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
12576456
Cyclosporine
  • Cyclosporine does not affect the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • Cyclosporine does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
10856430
Cyclosporine
  • Cyclosporine inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
16636798
Cyclosporins
  • Cyclosporins affects the activity of ABCC1 protein
15788683
Cytarabine
  • ABCC1 protein affects the chemical susceptibility to Cytarabine
17852453
Dactinomycin
  • ABCC1 protein results in chemical resistance to Dactinomycin
  • ABCC1 protein results in chemical resistance to Dactinomycin
12067707
Dactinomycin
  • ABCC1 protein results in chemical resistance to Dactinomycin
11455017
daidzein
  • daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
Daunorubicin
  • ABCC1 protein results in chemical resistance to Daunorubicin
  • ABCC1 protein results in chemical resistance to Daunorubicin
12657726
Daunorubicin
  • ABCC1 protein affects the export of Daunorubicin
  • PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
  • Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
15498506
Daunorubicin
  • ABCC1 protein results in decreased uptake of Daunorubicin
  • Daunorubicin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]
  • Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
  • Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
10856430
demethoxycurcumin
  • demethoxycurcumin results in decreased activity of ABCC1 protein
16021489, 15885658
demethoxycurcumin
  • demethoxycurcumin does not affect the expression of ABCC1 protein
16021489
Dexamethasone
  • Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA]
15205389
Diamide
  • ABCC1 protein does not affect the response to chemical Diamide
12653207
diosmetin
  • diosmetin results in decreased activity of ABCC1 protein
15670588
docetaxel
  • docetaxel results in increased expression of ABCC1 protein
15239124
Doxorubicin
  • Indomethacin inhibits the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
17940500
Doxorubicin
  • ABCC1 protein affects the transport of Doxorubicin
  • ABCC1 protein mutant form affects the transport of Doxorubicin
15581632
Doxorubicin
  • Doxorubicin results in increased expression of ABCC1 mRNA
18560228, 17852453
Doxorubicin
  • ABCC1 protein results in chemical sensitivity to Doxorubicin
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in chemical sensitivity to Doxorubicin]
12504668
Doxorubicin
  • GCLC protein inhibits the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
11560771
Doxorubicin
  • [Doxorubicin results in decreased expression of ABCC1 mRNA] which results in chemical sensitivity to Indomethacin
16331495
Doxorubicin
  • ABCC1 protein results in chemical resistance to Doxorubicin
11455017
Doxorubicin
  • ABCC1 results in chemical resistance to Doxorubicin
15548710
Doxorubicin
  • Acetylcysteine promotes the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
  • Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]]
15473893
Doxorubicin
  • Doxorubicin promotes the reaction [JUN protein binds to ABCC1 promoter]
  • Doxorubicin results in increased expression of ABCC1 protein
15880572
Doxorubicin
  • Haloperidol inhibits the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
15946544
Doxorubicin
  • ABCC1 protein does not affect the response to chemical Doxorubicin
12067707
Doxorubicin
  • ABCC1 protein results in chemical resistance to Doxorubicin
  • [copper (N-2-hydroxyacetophenone)glycinate results in decreased expression of ABCC1 protein] which results in chemical sensitivity to Doxorubicin
16289015
Doxorubicin
  • ABCC1 protein results in chemical resistance to Doxorubicin
12657726
Doxorubicin
  • ABCC1 protein does not affect the response to chemical Doxorubicin
12516967
Doxorubicin
  • ABCC1 protein results in chemical resistance to Doxorubicin
17940500, 10900222, 12657726, 12067707, 11560771, 15473893
Doxorubicin
  • Heparin affects the reaction [ABCC1 protein affects the transport of Doxorubicin]
17352253
Epirubicin
  • ABCC1 protein affects the chemical susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
12576456
Epirubicin
  • ABCC1 protein results in chemical resistance to Epirubicin
  • ABCC1 protein results in chemical resistance to Epirubicin
12657726
epsilon-viniferin
  • epsilon-viniferin inhibits the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
  • epsilon-viniferin results in decreased activity of ABCC1 protein
16827148
eriodictyol
  • eriodictyol results in decreased activity of ABCC1 protein
15670588
Estradiol
  • Estradiol results in decreased expression of ABCC1 mRNA
11080590
estradiol-17 beta-glucuronide
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]
15459206
Estrogens
  • Estrogens results in decreased expression of ABCC1 mRNA
11080590
Ethacrynic Acid
  • ABCC1 protein results in chemical resistance to Ethacrynic Acid
  • GSTP1 protein promotes the reaction [ABCC1 protein results in chemical resistance to Ethacrynic Acid]
  • [GCLC protein co-treated with GCLM protein] does not affect the reaction [ABCC1 protein results in chemical resistance to Ethacrynic Acid]
10900222
Ethinyl Estradiol
  • Ethinyl Estradiol affects the expression of ABCC1 mRNA
17555576
Ethinyl Estradiol
  • ABCC1 protein does not affect the uptake of Ethinyl Estradiol metabolite
14722317
Etoposide
  • ABCC1 protein results in chemical resistance to Etoposide
12657726
Etoposide
  • ABCC1 protein results in chemical resistance to Etoposide
  • ABCC1 protein does not affect the response to chemical Etoposide
12067707
Etoposide
  • ABCC1 protein results in chemical resistance to Etoposide
  • ABCC1 protein results in decreased uptake of Etoposide
  • Cyclosporine does not affect the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • Etoposide results in increased expression of ABCC1 mRNA
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]
  • Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
  • Verapamil inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
10856430
Etoposide
  • Silymarin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • hesperetin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • naringenin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • resveratrol inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • verlukast inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
16156793
Etoposide
  • ABCC1 protein results in chemical resistance to Etoposide
16156793, 10900222, 15999103
Etoposide
  • GSTP1 protein promotes the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in chemical resistance to Etoposide]
10900222
Etoposide
  • Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
15617835
Etoposide
  • ABCC1 results in chemical resistance to Etoposide
15460906
Etoposide
  • ABCC1 protein results in chemical resistance to Etoposide
12516967
Fenitrothion
  • ABCC1 protein results in chemical resistance to Fenitrothion
12765240
flavone
  • flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
  • flavone results in decreased activity of ABCC1 protein
15041478
Flavonoids
  • Flavonoids results in decreased expression of ABCC1 mRNA
  • Flavonoids results in decreased expression of ABCC1 protein
15465739
Flavonoids
  • Flavonoids analog results in decreased activity of ABCC1 protein
15670588
Flavonoids
  • Flavonoids results in decreased activity of ABCC1 protein
15916776
Fluo-3
  • ABCC1 protein affects the export of Fluo-3
15948026
fluorexon
  • ABCC1 protein results in increased export of fluorexon
  • Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
  • verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
16156793
fluorexon
  • ABCC1 protein affects the export of fluorexon
  • ABCC1 protein affects the transport of fluorexon
  • robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]
15670588
fluorexon
  • Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]
  • verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]
16004972
Fluorouracil
  • ABCC1 protein affects the chemical susceptibility to [Fluorouracil co-treated with Epirubicin co-treated with Cyclophosphamide]
12576456
Folic Acid
  • Folic Acid affects the expression of ABCC1 protein
15657365
galangin
  • galangin results in decreased activity of ABCC1 protein
15670588
Genistein
  • Genistein analog results in decreased activity of ABCC1 protein
15916776
Genistein
  • Genistein results in decreased activity of ABCC1 protein
15581599
Genistein
  • Genistein results in decreased activity of ABCC1 protein
  • [Genistein results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
12893836
Glucose
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]
10856430
Glutathione
  • ABCC1 protein affects the export of Glutathione
15561710
Glutathione
  • ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]
  • ABCC1 protein does not affect the transport of [arsenic acid co-treated with Glutathione]
15161912
Glutathione
  • Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]
15245331
Glutathione
  • ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]
16679408
Glutathione
  • ABCC1 protein affects the export of Glutathione
  • PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]
  • Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]
15498506
Glutathione
  • Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form
15581632
Glutathione
  • ABCC1 protein affects the export of Glutathione
15845416
Glutathione
  • Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein
15579473
Glutathione
  • Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]
15766272
Glutathione
  • ABCC1 protein results in increased export of Glutathione
  • GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
  • buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
12504668
Glutathione Disulfide
  • Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
15628876
Glyburide
  • Glyburide results in decreased activity of ABCC1 protein
15652236
grepafloxacin
  • ABCC1 protein affects the export of grepafloxacin
15948026
Haloperidol
  • Haloperidol inhibits the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
  • Haloperidol results in decreased expression of ABCC1 mRNA
15946544
Heparin
  • Heparin affects the activity of ABCC1 protein
  • Heparin affects the reaction [ABCC1 protein affects the transport of Doxorubicin]
17352253
hesperetin
  • hesperetin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
hydroxyhydroquinone
  • hydroxyhydroquinone results in increased expression of ABCC1 mRNA
17572062
Idarubicin
  • Idarubicin binds to and affects the folding of ABCC1 protein
11278000
Indomethacin
  • Indomethacin inhibits the reaction [ABCC1 protein results in chemical resistance to Doxorubicin]
17940500
Indomethacin
  • Indomethacin inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
16636798
Indomethacin
  • Indomethacin results in decreased expression of ABCC1 mRNA
18360721
Indomethacin
  • Indomethacin analog affects the activity of ABCC1 protein
15715484
Indomethacin
  • [Doxorubicin results in decreased expression of ABCC1 mRNA] which results in chemical sensitivity to Indomethacin
16331495
Indomethacin
  • Indomethacin results in decreased activity of ABCC1 protein
17940500, 15916776, 15581599, 15715484
Indomethacin
  • Indomethacin results in decreased activity of ABCC1 protein
  • [Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
12893836
Indomethacin
  • Indomethacin results in decreased activity of ABCC1 protein
  • Indomethacin results in decreased activity of ABCC1 protein
15804283
irinotecan
  • [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1
15897249
irinotecan
  • ABCC1 protein results in chemical resistance to irinotecan
16815871
Iron
  • ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron]
16679408
Isoflavones
  • Isoflavones analog results in decreased activity of ABCC1 protein
15916776
kaempferol
  • kaempferol results in decreased activity of ABCC1 protein
15670588
Leukotriene C4
  • ABCC1 protein affects the transport of Leukotriene C4
12657726
Leukotriene C4
  • Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]
15459206, 15355964
Leukotriene C4
  • ABCC1 protein affects the transport of Leukotriene C4
12516967
Leukotriene C4
  • [5'-adenylyl (beta,gamma-methylene)diphosphonate binds to ABCC1 protein] does not affect the reaction [Leukotriene C4 binds to ABCC1 protein]
  • [Adenosine Triphosphate analog binds to ABCC1 protein] does not affect the reaction [Leukotriene C4 binds to ABCC1 protein]
  • [Adenosine Triphosphate binds to ABCC1 protein] inhibits the reaction [Leukotriene C4 binds to ABCC1 protein]
15755910
Leukotriene C4
  • Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]
15245331
Leukotriene C4
  • Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
  • Leukotriene C4 analog binds to ABCC1 protein
15628876
Lipopolysaccharides
  • Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA]
  • Lipopolysaccharides results in increased expression of ABCC1 mRNA
15205389
Luteolin
  • Luteolin results in decreased activity of ABCC1 protein
15670588
Mefloquine
  • Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]
  • Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
  • Mefloquine inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]
  • Mefloquine inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
  • Mefloquine results in decreased activity of ABCC1 protein
16004972
Melphalan
  • ABCC1 protein affects the export of Melphalan analog
11115505
Mercuric Chloride
  • Mercuric Chloride results in increased expression of ABCC1 mRNA
  • Mercuric Chloride results in increased expression of and affects the localization of ABCC1 protein
  • SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of and affects the localization of ABCC1 protein]
15585369
Mercuric Chloride
  • ABCC1 protein affects the export of Mercuric Chloride
  • ABCC1 protein affects the export of and results in chemical resistance to Mercuric Chloride
  • Mercuric Chloride results in increased expression of ABCC1 mRNA
  • Mercuric Chloride results in increased expression of ABCC1 protein
15590114
Mercury
  • ABCC1 protein affects the export of and results in chemical resistance to Mercury
  • Mercury results in increased expression of ABCC1 mRNA
  • Mercury results in increased expression of ABCC1 protein
15590114
Methotrexate
  • ABCC1 protein affects the transport of Methotrexate
15718312
Methoxychlor
  • ABCC1 gene mutant form results in chemical sensitivity to Methoxychlor
  • ABCC1 protein results in increased export of and results in chemical resistance to Methoxychlor
12765240
methoxy-morpholinyl-doxorubicin
  • methoxy-morpholinyl-doxorubicin binds to and affects the folding of ABCC1 protein
11278000
monomethylarsonic acid
  • monomethylarsonic acid results in increased expression of ABCC1 mRNA
  • monomethylarsonic acid results in increased expression of ABCC1 protein
16436460
morin
  • morin results in decreased activity of ABCC1 protein
15670588
myricetin
  • myricetin results in decreased activity of ABCC1 protein
15670588
myricetin
  • myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]
  • myricetin inhibits the reaction [ABCC1 protein affects the export of and results in chemical resistance to Vincristine]
  • myricetin inhibits the reaction [ABCC1 protein results in chemical resistance to Vincristine]
15896345
naringenin
  • naringenin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
Nelfinavir
  • ABCC1 gene SNP does not affect the response to chemical Nelfinavir
  • ABCC1 protein affects the transport of Nelfinavir
16041239
nickel sulfate
  • nickel sulfate results in increased expression of ABCC1 mRNA
16780908
Nicotine
  • Nicotine metabolite does not affect the activity of ABCC1 protein
15795089
nicotine N-glucuronide
  • nicotine N-glucuronide does not affect the activity of ABCC1 protein
15795089
Nitric Oxide
  • ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]
  • ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron]
16679408
N-substituted Glycines
  • N-substituted Glycines analog binds to and results in decreased activity of ABCC1 protein
15644429
Oncostatin M
  • Oncostatin M results in increased expression of ABCC1 mRNA
15654950
Paclitaxel
  • ABCC1 results in chemical resistance to Paclitaxel
15548710
PAK 104P
  • PAK 104P inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
  • PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]
15498506
Paraquat
  • ABCC1 protein does not affect the response to chemical Paraquat
12653207
Plant Extracts
  • Plant Extracts results in increased expression of ABCC1 mRNA
18351577
Plant Extracts
  • Plant Extracts results in decreased expression of ABCC1 mRNA
  • Plant Extracts results in decreased expression of ABCC1 protein
15465739
pluronic block copolymer p85
  • pluronic block copolymer p85 results in decreased folding of and results in decreased activity of ABCC1 protein
15648254
polyphenols
  • polyphenols results in decreased expression of ABCC1 mRNA
  • polyphenols results in decreased expression of ABCC1 protein
15465739
Potassium Dichromate
  • ABCC1 protein does not affect the response to chemical Potassium Dichromate
12653207
Probenecid
  • Probenecid results in decreased activity of ABCC1 protein
  • Probenecid results in decreased activity of ABCC1 protein
15804283
Probenecid
  • Probenecid results in decreased activity of ABCC1 protein
15456083, 12387749
Probenecid
  • Probenecid results in decreased activity of ABCC1 protein
15916776, 15585369, 15652236
Probenecid
  • Probenecid results in decreased activity of ABCC1 protein
  • [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
12893836
Prodigiosin
  • Prodigiosin does not affect the expression of ABCC1 protein
  • Prodigiosin results in increased expression of ABCC1 mRNA
15746575
Prostaglandins E
  • Mefloquine inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]
  • verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]
16004972
Protease Inhibitors
  • ABCC1 protein affects the export of Protease Inhibitors
15731742
pyrene
  • pyrene does not affect the expression of ABCC1 mRNA
15566942
Quercetin
  • ABCC1 protein results in chemical sensitivity to Quercetin
  • Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Quercetin does not affect the reaction [ABCC1 protein binds to 8-azidoadenosine 5'-triphosphate]
  • Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
16156793
Quercetin
  • Quercetin results in increased expression of ABCC1 protein
  • Quercetin results in increased expression of ABCC1 mRNA
11836020
Quercetin
  • Mefloquine inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
  • verlukast inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
16004972
Quercetin
  • Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
15041478
Quercetin
  • Quercetin results in decreased activity of ABCC1 protein
15670588, 15041478
Quinidine
  • Quinidine results in decreased activity of ABCC1 protein
15666293
resveratrol
  • ABCC1 protein results in chemical resistance to resveratrol
  • resveratrol inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
resveratrol
  • resveratrol does not affect the activity of ABCC1 protein
  • resveratrol does not affect the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
16827148
rhapontin
  • rhapontin does not affect the activity of ABCC1 protein
  • rhapontin does not affect the reaction [ABCC1 protein results in increased transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
16827148
Rifampin
  • Rifampin does not affect the expression of ABCC1 mRNA
  • Rifampin does not affect the expression of ABCC1 protein
11836020
robinetin
  • robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]
  • robinetin results in decreased activity of ABCC1 protein
15670588
romidepsin
  • ABCC1 protein binds to and affects the export of romidepsin
15634944
romidepsin
  • ABCC1 protein results in chemical resistance to romidepsin
16049968
S-(2,4-dinitrophenyl)glutathione
  • ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione
  • Mefloquine inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
  • verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
16004972
S-(2,4-dinitrophenyl)glutathione
  • ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione
  • Quercetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
16156793
S-(2,4-dinitrophenyl)glutathione
  • ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione
  • Quercetin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
  • flavone inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
  • taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
15041478
SB 203580
  • SB 203580 inhibits the reaction [Mercuric Chloride results in increased expression of and affects the localization of ABCC1 protein]
15585369
selenomethylselenocysteine
  • [selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1
15897249
Silymarin
  • Silymarin does not affect the reaction [ABCC1 protein binds to 8-azidoadenosine 5'-triphosphate]
  • Silymarin inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
  • Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
16156793
sitosterol
  • ABCC1 protein does not affect the transport of sitosterol
12488046
sodium arsenite
  • IFNG protein promotes the reaction [sodium arsenite results in increased expression of ABCC1 protein]
  • TGFB1 protein inhibits the reaction [sodium arsenite results in increased expression of ABCC1 protein]
  • sodium arsenite results in increased expression of ABCC1 mRNA
  • sodium arsenite results in increased expression of ABCC1 protein
  • ABCC1 protein results in increased export of sodium arsenite
17003472
sodium arsenite
  • ABCC1 protein results in chemical resistance to sodium arsenite
  • sodium arsenite results in increased expression of ABCC1 mRNA
  • sodium arsenite results in increased expression of ABCC1 protein
11455017
sodium arsenite
  • ABCC1 protein affects the export of sodium arsenite
  • sodium arsenite results in increased expression of ABCC1 mRNA
  • sodium arsenite results in increased expression of ABCC1 protein
15694464
sodium arsenite
  • ABCC1 protein results in chemical resistance to sodium arsenite
8947035
Sodium Azide
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]]
  • Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]
  • Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
  • Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
10856430
Soybean Oil
  • Soybean Oil affects the expression of ABCC1 mRNA
15770074
Sulfinpyrazone
  • Sulfinpyrazone results in decreased activity of ABCC1 protein
15044619
Sulfinpyrazone
  • Sulfinpyrazone results in decreased activity of ABCC1 protein
  • [Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
12893836
Tamoxifen
  • Tamoxifen affects the expression of ABCC1 mRNA
17555576
Tamoxifen
  • ABCC1 protein does not affect the transport of Tamoxifen
15718312
taxane
  • taxane analog affects the activity of ABCC1 protein
15771464
taxifolin
  • taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
  • taxifolin results in decreased activity of ABCC1 protein
15041478
technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
  • ABCC1 protein affects the transport of technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane analog
15989470
Technetium Tc 99m Sestamibi
  • ABCC1 protein affects the transport of Technetium Tc 99m Sestamibi analog
15989470
tectochrysin
  • tectochrysin does not affect the activity of ABCC1 protein
15930306
tert-Butylhydroperoxide
  • ABCC1 protein does not affect the response to chemical tert-Butylhydroperoxide
12653207
Tetradecanoylphorbol Acetate
  • Tetradecanoylphorbol Acetate results in decreased expression of ABCC1 protein
15517594
Tocopherols
  • Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
  • Tocopherols results in decreased activity of ABCC1 protein
15617835
trimethylarsine oxide
  • trimethylarsine oxide results in increased expression of ABCC1 mRNA
  • trimethylarsine oxide results in increased expression of ABCC1 protein
16436460
Tunicamycin
  • Tunicamycin results in increased expression of ABCC1 mRNA
17127020
U 0126
  • U 0126 results in decreased expression of ABCC1 mRNA
  • U 0126 results in decreased expression of ABCC1 protein
15526378
Ursodeoxycholic Acid
  • Ursodeoxycholic Acid affects the expression of ABCC1 mRNA
15452192
valspodar
  • valspodar does not affect the activity of ABCC1 protein
15788683
Vanadates
  • Vanadates inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
10856430
Verapamil
  • Verapamil results in decreased activity of ABCC1 protein
15451006, 15044619
Verapamil
  • Verapamil does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
  • Verapamil inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Daunorubicin]
  • Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
10856430
Verapamil
  • Verapamil results in decreased activity of ABCC1 protein
15666293
Verapamil
  • Verapamil inhibits the reaction [ABCC1 protein affects the export of Daunorubicin]
  • Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]
15498506
Verapamil
  • Verapamil inhibits the reaction [ABCC1 protein affects the export of 5-carboxyfluorescein diacetate]
16636798
verlukast
  • verlukast results in decreased activity of ABCC1 protein
16049968, 15916776, 15041478, 15451006, 16004972
verlukast
  • [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
  • verlukast results in decreased activity of ABCC1 protein
12893836
verlukast
  • verlukast inhibits the reaction [ABCC1 protein results in chemical resistance to Etoposide]
  • verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]
16156793
verlukast
  • verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin]
15245331
verlukast
  • verlukast results in decreased activity of ABCC1 protein
15804283
verlukast
  • verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]
  • verlukast inhibits the reaction [ABCC1 protein affects the transport of S-(2,4-dinitrophenyl)glutathione]
  • verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC1 protein]
  • verlukast inhibits the reaction [Quercetin results in increased activity of ABCC1 protein]
16004972
verlukast
  • verlukast results in decreased activity of ABCC1 protein
15744065, 12490585, 11455017, 15282097, 15590114
verlukast
  • verlukast results in decreased activity of ABCC1 protein
15804283, 15694464
Vinblastine
  • ABCC1 protein results in chemical resistance to Vinblastine
11455017
Vinblastine
  • Vinblastine does not affect the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]
10856430
Vinblastine
  • ABCC1 protein results in chemical resistance to Vinblastine
16156793
Vincristine
  • ABCC1 protein results in chemical resistance to Vincristine
16042792, 10900222, 12067707, 15044619, 15896345
Vincristine
  • ABCC1 protein results in chemical resistance to Vincristine
12657726
Vincristine
  • ABCC1 protein results in chemical resistance to Vincristine
12067707
Vincristine
  • [Genistein results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
  • [Indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
  • [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
  • [Sulfinpyrazone results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
  • [verlukast results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
12893836
Vincristine
  • ABCC1 protein affects the transport of Vincristine
  • ABCC1 protein mutant form affects the transport of Vincristine
15581632
Vincristine
  • ABCC1 protein affects the export of Vincristine
  • ABCC1 protein affects the export of and results in chemical resistance to Vincristine
  • myricetin inhibits the reaction [ABCC1 protein affects the export of Vincristine]
  • myricetin inhibits the reaction [ABCC1 protein affects the export of and results in chemical resistance to Vincristine]
  • myricetin inhibits the reaction [ABCC1 protein results in chemical resistance to Vincristine]
15896345
Vincristine
  • GSTP1 protein promotes the reaction [ABCC1 protein results in chemical resistance to Vincristine]
  • [GCLC protein co-treated with GCLM protein] does not affect the reaction [ABCC1 protein results in chemical resistance to Vincristine]
10900222
Vincristine
  • ABCC1 protein results in chemical resistance to Vincristine
12516967
Vitamin K 3
  • ABCC1 protein does not affect the response to chemical Vitamin K 3
12653207

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Heart Diseases marker 16330681
Carcinoma, Renal Cell inferred via Vincristine 16201981
Hodgkin Disease inferred via Vincristine 17606976, 16794504, 15147373, 16135485
Melanoma, Amelanotic inferred via Vincristine 15990972
Myocardial Infarction inferred via Vincristine 17284715
Hodgkin Disease inferred via Vinblastine 18180244, 18501091
Melanoma inferred via Vinblastine 16809738, 16432458, 15577320, 18176117, 15577323, 17761969, 18332650, 12374674, 18505091, 16248763
Neutropenia inferred via Vinblastine 17378895
Vaginal Neoplasms inferred via Vinblastine 15577323
Mammary Neoplasms, Experimental inferred via valspodar 14633655
Cholestasis inferred via Ursodeoxycholic Acid 16487557
Cholestasis, Intrahepatic inferred via Ursodeoxycholic Acid 14728856
Acrocephalosyndactylia inferred via U 0126 17694057
Leukemia, Monocytic, Acute inferred via U 0126 16972261
Ovarian Neoplasms inferred via U 0126 16211241
Mammary Neoplasms, Experimental inferred via Tocopherols 17927505
Mesothelioma inferred via Tocopherols 15878867
Lung Neoplasms inferred via Tetradecanoylphorbol Acetate 11807781
Mammary Neoplasms, Experimental inferred via Tetradecanoylphorbol Acetate 8985016
Pancreatic Neoplasms inferred via Tetradecanoylphorbol Acetate 15976015
Skin Neoplasms inferred via Tetradecanoylphorbol Acetate 8985016, 11807781
Breast Neoplasms inferred via Tamoxifen 16202921, 15668708, 17440819, 17893378, 17261762, 17049068, 16873071, 16818667, 11161223, 17242785, 15565566
Carcinoma, Hepatocellular inferred via Tamoxifen 16924424
Carcinoma, Transitional Cell inferred via Tamoxifen 17572228
Endometrial Neoplasms inferred via Tamoxifen 16202921, 17893378
Fatty Liver inferred via Tamoxifen 14986274
Female Urogenital Diseases inferred via Tamoxifen 16709447
Lipidoses inferred via Tamoxifen 15342952
Liver Cirrhosis, Experimental inferred via Tamoxifen 18564211
Liver Neoplasms inferred via Tamoxifen 16684651
Mammary Neoplasms, Experimental inferred via Tamoxifen 11731420, 14580682, 16827153
Melanoma inferred via Tamoxifen 12393984
Melanoma, Amelanotic inferred via Tamoxifen 15990972
Spermatocele inferred via Tamoxifen 16709447
Urinary Bladder Neoplasms inferred via Tamoxifen 16712894, 17572228
Adrenal Gland Neoplasms inferred via sodium arsenite 15276417
Adrenocortical Adenoma inferred via sodium arsenite 16712894
Carcinoma, Hepatocellular inferred via sodium arsenite 15276417, 16507464
Carcinoma, Squamous Cell inferred via sodium arsenite 18572023
Genital Neoplasms, Female inferred via sodium arsenite 16452187
Hodgkin Disease inferred via sodium arsenite 12676792
Liver Neoplasms inferred via sodium arsenite 15276417, 16712894
Lung Neoplasms inferred via sodium arsenite 15276417, 16712894, 17077188
Melanoma inferred via sodium arsenite 16487513
Neoplasms inferred via sodium arsenite 11559025
Neural Tube Defects inferred via sodium arsenite 12854658
Ovarian Neoplasms inferred via sodium arsenite 15276417
Prostatic Neoplasms inferred via sodium arsenite 16039940
Skin Neoplasms inferred via sodium arsenite 18572023
Spinal Dysraphism inferred via sodium arsenite 12854658
Urinary Bladder Neoplasms inferred via sodium arsenite 11723127, 16452187, 16712894
Uterine Cervical Neoplasms inferred via sodium arsenite 11813266
Vascular Diseases inferred via sodium arsenite 17056641
Inflammation inferred via Silymarin 17213517
Liver Cirrhosis inferred via Silymarin 17213517
Liver Cirrhosis, Experimental inferred via Silymarin 15754394, 15864749, 18277467, 17198567
Liver Diseases inferred via Silymarin 17213517
Liver Diseases, Alcoholic inferred via Silymarin 17213517
Mushroom Poisoning inferred via Silymarin 17213517
Mycobacterium Infections inferred via Rifampin 18474467
Tuberculosis inferred via Rifampin 18397238, 15236969
Adenoma inferred via resveratrol 15688382
Alzheimer Disease inferred via resveratrol 16183991, 16162502
Arthritis, Experimental inferred via resveratrol 17115116
Atherosclerosis inferred via resveratrol 16873680, 17967414
Brain Ischemia inferred via resveratrol 17600658
Breast Neoplasms inferred via resveratrol 17651959, 17534123, 16393696
Carcinoma, Hepatocellular inferred via resveratrol 16227395
Carcinoma, Lewis Lung inferred via resveratrol 16675471
Carcinoma, Squamous Cell inferred via resveratrol 16227395
Cardiovascular Diseases inferred via resveratrol 15458977
Colitis inferred via resveratrol 16474422
Colonic Neoplasms inferred via resveratrol 16338953
Colorectal Neoplasms inferred via resveratrol 16550006
Diabetes Mellitus, Experimental inferred via resveratrol 16873680
Diabetic Nephropathies inferred via resveratrol 16286809
Edema inferred via resveratrol 8985016
Encephalomyelitis, Autoimmune, Experimental inferred via resveratrol 17872969
Enterocolitis, Necrotizing inferred via resveratrol 17923197
Herpes Simplex inferred via resveratrol 16876885
Hypercholesterolemia inferred via resveratrol 17188708
Hyperlipidemias inferred via resveratrol 16873680
Hypertrophy, Left Ventricular inferred via resveratrol 17488730
Infarction, Middle Cerebral Artery inferred via resveratrol 17600658
Inflammation inferred via resveratrol 16366677
Influenza, Human inferred via resveratrol 16624496
Kidney Failure, Acute inferred via resveratrol 16538975
Leukemia, Promyelocytic, Acute inferred via resveratrol 16087638
Lymphoma, B-Cell inferred via resveratrol 17088997
Lymphoma, Non-Hodgkin inferred via resveratrol 14749477
Mammary Neoplasms, Animal inferred via resveratrol 15688416
Mammary Neoplasms, Experimental inferred via resveratrol 8985016, 11606380
Melanoma inferred via resveratrol 17992120
Metabolic Diseases inferred via resveratrol 17112576
Multiple Myeloma inferred via resveratrol 14749477, 17049120, 16490592, 16267019, 17935668, 17164350
Muscular Atrophy, Spinal inferred via resveratrol 17962980
Myocardial Infarction inferred via resveratrol 17188708, 16456233, 16317513, 17015251, 16525036, 17125593
Myocardial Ischemia inferred via resveratrol 17125593, 17015251
Myocarditis inferred via resveratrol 17322642
Neoplasms, Experimental inferred via resveratrol 8985016
Neurodegenerative Diseases inferred via resveratrol 17652729
Neurogenic Inflammation inferred via resveratrol 17929310
Osteoporosis, Postmenopausal inferred via resveratrol 17513867
Prenatal Exposure Delayed Effects inferred via resveratrol 16679765
Prostatic Neoplasms inferred via resveratrol 17675339, 16731767, 17636462, 17718901, 15767336, 17804756
Renal Insufficiency, Chronic inferred via resveratrol 16325855
Reperfusion Injury inferred via resveratrol 17058453, 17520802, 15827377, 16317513, 16314181
Skin Neoplasms inferred via resveratrol 15837718, 8985016
STROKE, ISCHEMIC inferred via resveratrol 16321402
Tongue Neoplasms inferred via resveratrol 16227395
Uterine Cervical Neoplasms inferred via resveratrol 17473185
Uterine Neoplasms inferred via resveratrol 17044934
Ventricular Dysfunction, Left inferred via resveratrol 17488730
Cadmium Poisoning inferred via Quercetin 16962696
Influenza, Human inferred via Quercetin 16624496
Kidney Diseases inferred via Quercetin 16962696
Liver Cirrhosis, Experimental inferred via Quercetin 12741479
Neurogenic Inflammation inferred via Quercetin 17929310
Pancreatic Neoplasms inferred via Quercetin 16965848
Colonic Neoplasms inferred via polyphenols 16293270
Inflammation inferred via polyphenols 16366677
Liver Diseases inferred via polyphenols 16698588
Alzheimer Disease inferred via Plant Extracts 16962711
Brain Ischemia inferred via Plant Extracts 16041641
HIV Infections inferred via Plant Extracts 12878215
Hot Flashes inferred via Plant Extracts 16566672
Hyperhomocysteinemia inferred via Plant Extracts 16484555
Inflammation inferred via Plant Extracts 16366677
Liver Cirrhosis, Experimental inferred via Plant Extracts 15479170
Neurobehavioral Manifestations inferred via Plant Extracts 17168769
Prostatic Neoplasms inferred via Plant Extracts 17804756
Agricultural Workers' Diseases inferred via Paraquat 11874814
Gliosis inferred via Paraquat 11124998
Nerve Degeneration inferred via Paraquat 16893418
Parkinson Disease inferred via Paraquat 12911755, 16510128, 15451049, 11124998, 15824117, 11181820, 16140633, 11445065
Pneumonia inferred via Paraquat 12504350
Pulmonary Fibrosis inferred via Paraquat 16324872, 17997886
Respiratory Distress Syndrome, Adult inferred via Paraquat 11700416
Respiratory Sounds inferred via Paraquat 11874814
Retinal Degeneration inferred via Paraquat 16458197
Breast Neoplasms inferred via Paclitaxel 16244791, 15136595, 18323546, 11325840, 18234424
Carcinoma, Hepatocellular inferred via Paclitaxel 16313753
Liposarcoma inferred via Paclitaxel 17353645
Lymphoma, Non-Hodgkin inferred via Paclitaxel 14749477
Melanoma inferred via Paclitaxel 16342250, 12040289
Multiple Myeloma inferred via Paclitaxel 14749477
Ovarian Neoplasms inferred via Paclitaxel 11161223
Prostatic Neoplasms inferred via Paclitaxel 16356831, 16729912, 17136230
Alzheimer Disease inferred via Nitric Oxide 17556102
Breast Neoplasms inferred via Nitric Oxide 15631943
Cholestasis inferred via Nitric Oxide 16919318
Dementia, Vascular inferred via Nitric Oxide 17556102
Hypertension, Pulmonary inferred via Nitric Oxide 15838368
Intestinal Diseases inferred via Nitric Oxide 10210152
Lymphoma inferred via Nitric Oxide 16166326
Alzheimer Disease inferred via Nicotine 16627626
Neoplasms inferred via Nicotine 16365874
Neovascularization, Pathologic inferred via Nicotine 16365874
Dermatitis, Allergic Contact inferred via nickel sulfate 16780908
HIV Infections inferred via Nelfinavir 15388451
Liver Cirrhosis, Experimental inferred via naringenin 14709902
Liver Diseases inferred via naringenin 16945181
Liver Cirrhosis, Experimental inferred via morin 18629640
Neoplasms inferred via methoxy-morpholinyl-doxorubicin 15465924
Infertility, Male inferred via Methoxychlor 16467254, 11955947
Arthritis, Rheumatoid inferred via Methotrexate 17286800
Breast Neoplasms inferred via Methotrexate 16978400
Graft vs Host Disease inferred via Methotrexate 16518429
Liver Cirrhosis inferred via Methotrexate 14986274
Mucositis inferred via Methotrexate 17488658
Psoriasis inferred via Methotrexate 17410198
Autoimmune Diseases inferred via Mercury 16634805
Glycosuria, Renal inferred via Mercuric Chloride 2918855
Renal Aminoacidurias inferred via Mercuric Chloride 2918855
Melanoma inferred via Melphalan 18388930
Prostatic Neoplasms inferred via Melphalan 15749863
Hemolytic-Uremic Syndrome inferred via Lipopolysaccharides 16366002
Inflammation inferred via Lipopolysaccharides 17255318, 17963957
Iron Metabolism Disorders inferred via Lipopolysaccharides 17255318
Respiratory Hypersensitivity inferred via Lipopolysaccharides 10835634
Breast Neoplasms inferred via kaempferol 16756079
Cardiovascular Diseases inferred via kaempferol 16756079
Osteoporosis inferred via kaempferol 16756079
Cardiovascular Diseases inferred via Isoflavones 17689850
Colorectal Neoplasms inferred via Isoflavones 17116718
Hot Flashes inferred via Isoflavones 17290160
Osteoporosis inferred via Isoflavones 16562857
Prostatic Neoplasms inferred via Isoflavones 16365062, 17374662, 17219775, 17571952
alpha 1-Antitrypsin Deficiency inferred via Iron 16640825
Alzheimer Disease inferred via Iron 16640825, 16563566
Anemia inferred via Iron 16566752, 16434484
Anemia, Iron-Deficiency inferred via Iron 17162259, 17147795, 17163184, 17375513, 16569441
Anemia, Sideroblastic inferred via Iron 16910769
Arrhythmias, Cardiac inferred via Iron 16604332
Atherosclerosis inferred via Iron 16640825, 16632123
Bacterial Infections inferred via Iron 16640825
Cardiomyopathies inferred via Iron 16640825
Cardiomyopathy, Dilated inferred via Iron 16604332
Colonic Neoplasms inferred via Iron 16640825
Diabetes Mellitus inferred via Iron 16640825, 16604332
Diabetes Mellitus, Type 1 inferred via Iron 16506275
Diabetes Mellitus, Type 2 inferred via Iron 16506275
Fatty Liver inferred via Iron 16640825
Friedreich Ataxia inferred via Iron 16640825, 16604332
Hemochromatosis inferred via Iron 17236123, 17255318, 16640825, 16574947, 16604332, 17053826
Hemosiderosis inferred via Iron 16604332
Hepatitis, Viral, Human inferred via Iron 16640825
Hepatolenticular Degeneration inferred via Iron 17182432
Hepatomegaly inferred via Iron 16890145
HIV Infections inferred via Iron 16597321
Hypogonadism inferred via Iron 16640825
Hypothyroidism inferred via Iron 16640825
Iron Metabolism Disorders inferred via Iron 17163184
Lewy Body Disease inferred via Iron 16563566
Liver Cirrhosis inferred via Iron 16640825
Liver Diseases, Alcoholic inferred via Iron 17207112, 16737972
Liver Neoplasms inferred via Iron 16640825
Lung Neoplasms inferred via Iron 16640825
Macular Degeneration inferred via Iron 16640825
Multiple Sclerosis, Chronic Progressive inferred via Iron 17086897
Mycoses inferred via Iron 16640825
Myocardial Ischemia inferred via Iron 16604332
Myocardial Reperfusion Injury inferred via Iron 16604332
Nephrotic Syndrome inferred via Iron 17178036
Neurodegenerative Diseases inferred via Iron 17296847, 16604332
Osteoarthritis inferred via Iron 16640825
Osteoporosis inferred via Iron 16640825, 16648989
Parkinson Disease inferred via Iron 16640825, 16563566
Pituitary Diseases inferred via Iron 16604332
Poisoning inferred via Iron 16604332
Porphyria Cutanea Tarda inferred via Iron 16640825
Pre-Eclampsia inferred via Iron 16640825
Protozoan Infections inferred via Iron 16640825
Restless Legs Syndrome inferred via Iron 16930377
Sudden Infant Death inferred via Iron 16640825
Tuberculosis inferred via Iron 16597321
Colonic Neoplasms inferred via irinotecan 17725105
Colorectal Neoplasms inferred via irinotecan 16303861, 17454858, 18259882, 15273666
Neoplasm Metastasis inferred via irinotecan 18259882
Stomach Neoplasms inferred via irinotecan 15723263
Adenoma inferred via Indomethacin 11497255
Alzheimer Disease inferred via Indomethacin 15579461
Breast Neoplasms inferred via Indomethacin 17401462
Carcinoma, Hepatocellular inferred via Indomethacin 16391822
Colonic Neoplasms inferred via Indomethacin 11260862, 15963497, 15786552
Colorectal Neoplasms inferred via Indomethacin 18059344, 17054584, 12606626
Duodenal Ulcer inferred via Indomethacin 17045617, 16699067, 17202747
Edema inferred via Indomethacin 8985016
Enteritis inferred via Indomethacin 16328016
Esophageal Neoplasms inferred via Indomethacin 11005569
Glioblastoma inferred via Indomethacin 12870263
Hyperlipidemias inferred via Indomethacin 17546600
Ileal Diseases inferred via Indomethacin 10574470
Intestinal Diseases inferred via Indomethacin 15610444, 17329856, 15831440, 10210152
Jejunal Diseases inferred via Indomethacin 10574470
Leukemia, Myelogenous, Chronic, BCR-ABL Positive inferred via Indomethacin 10785260
Leukemia, Myeloid, Acute inferred via Indomethacin 18360721
Lung Neoplasms inferred via Indomethacin 11497255
Pain inferred via Indomethacin 17440234
Stomach Diseases inferred via Indomethacin 17207306
Stomach Ulcer inferred via Indomethacin 16934674, 12467913, 18299717, 10878458, 15104355, 12077510, 17654042
Ulcer inferred via Indomethacin 10574470
Leukemia, Myeloid, Acute inferred via Idarubicin 16271486
Leukemia, Promyelocytic, Acute inferred via Idarubicin 17107899
Liver Cirrhosis, Experimental inferred via Heparin 16904936
Neurotoxicity Syndromes inferred via Glyburide 16725203
Carcinoma, Squamous Cell inferred via Glutathione 17015178
Breast Neoplasms inferred via Genistein 17200150, 16541309, 16873071
Carcinoma, Hepatocellular inferred via Genistein 16924424
Cardiovascular Diseases inferred via Genistein 16332659
Colonic Neoplasms inferred via Genistein 17182828
Diabetes Mellitus, Type 2 inferred via Genistein 16647724
Endometrial Hyperplasia inferred via Genistein 16402032
Glioblastoma inferred via Genistein 16598420
Liver Cirrhosis, Experimental inferred via Genistein 17823541
Mammary Neoplasms, Experimental inferred via Genistein 14578162, 12929590
Myocardial Infarction inferred via Genistein 17141266
Myocardial Reperfusion Injury inferred via Genistein 17141266
Osteoporosis, Postmenopausal inferred via Genistein 16169203
Prostatic Neoplasms inferred via Genistein 16925846, 15378649, 15256057
Adenoma inferred via Folic Acid 16963246
Alzheimer Disease inferred via Folic Acid 17116317
Breast Neoplasms inferred via Folic Acid 16777985
Cardiovascular Diseases inferred via Folic Acid 16755160
Colorectal Neoplasms inferred via Folic Acid 16963246, 17245555, 17087956, 16985020, 17116713
Diabetes Mellitus, Type 2 inferred via Folic Acid 16886840
Endometrial Neoplasms inferred via Folic Acid 17301261
Exfoliation Syndrome inferred via Folic Acid 16504073
Gastritis inferred via Folic Acid 17171786
Glaucoma inferred via Folic Acid 16504073
Heart Defects, Congenital inferred via Folic Acid 17286298, 16524890
HIV Seropositivity inferred via Folic Acid 17209195
Hyperhomocysteinemia inferred via Folic Acid 16397167, 16865747, 16433478, 16395265, 16755160
Liver Diseases inferred via Folic Acid 16877991
Lupus Erythematosus, Systemic inferred via Folic Acid 17718048
Maxillofacial Abnormalities inferred via Folic Acid 16832597
Neural Tube Defects inferred via Folic Acid 17438019
Neutropenia inferred via Folic Acid 16322990
Schizophrenia inferred via Folic Acid 16641680
Spinal Cord Diseases inferred via Folic Acid 16361298
Stomach Neoplasms inferred via Folic Acid 17171786
Stroke inferred via Folic Acid 16517955
Breast Neoplasms inferred via Fluorouracil 15136595
Carcinoid Tumor inferred via Fluorouracil 16051944
Colonic Neoplasms inferred via Fluorouracil 17725105
Colorectal Neoplasms inferred via Fluorouracil 17594712, 17695437, 17255274, 17401013, 17454858, 16303861
Inflammation inferred via Flavonoids 17296493
Bone Marrow Neoplasms inferred via Etoposide 14601052
Breast Neoplasms inferred via Etoposide 16322251
Herpes Simplex inferred via Etoposide 10809021
Hodgkin Disease inferred via Etoposide 17606976, 16135485, 15147373, 16200630, 18180244
Lymphoma inferred via Etoposide 12556972, 12854902
Sarcoma, Ewing's inferred via Etoposide 14601052
Acne Vulgaris inferred via Ethinyl Estradiol 17505938
Adenocarcinoma inferred via Ethinyl Estradiol 14692618
Arteriosclerosis inferred via Ethinyl Estradiol 11256880
Arthritis, Experimental inferred via Ethinyl Estradiol 15885639
Cholestasis inferred via Ethinyl Estradiol 17110522, 16919318, 17681005, 15861022, 11677210, 16105132, 17333356
Encephalomyelitis, Autoimmune, Experimental inferred via Ethinyl Estradiol 12538720
Fatty Liver inferred via Ethinyl Estradiol 15345470
Hypospadias inferred via Ethinyl Estradiol 16569931, 16945680
Infertility, Female inferred via Ethinyl Estradiol 12013081
Infertility, Male inferred via Ethinyl Estradiol 17937319
Panic Disorder inferred via Ethinyl Estradiol 11578682
Pruritus inferred via Ethinyl Estradiol 16919318, 15861022
Spermatocele inferred via Ethinyl Estradiol 16709447
Thrombophilia inferred via Ethinyl Estradiol 11994571
Thrombosis inferred via Ethinyl Estradiol 15669648
Uterine Neoplasms inferred via Ethinyl Estradiol 14692618
Venous Thrombosis inferred via Ethinyl Estradiol 15869587
Critical Illness inferred via Estrogens 16670151
Wounds and Injuries inferred via Estrogens 11172683
Breast Neoplasms inferred via Estradiol 17289903, 12948864, 14630087, 17018787, 18497071, 17261762
Candidiasis, Vulvovaginal inferred via Estradiol 16111702
Carcinoma, Hepatocellular inferred via Estradiol 16924424
Herpes Genitalis inferred via Estradiol 15709030
Hot Flashes inferred via Estradiol 17088409
Insulin Resistance inferred via Estradiol 16393666, 16627594
Kidney Diseases inferred via Estradiol 15618244
Kidney Neoplasms inferred via Estradiol 15610895
Liver Cirrhosis, Experimental inferred via Estradiol 14716833, 14659978
Mammary Neoplasms, Experimental inferred via Estradiol 17203775, 11807958, 16891317, 11408345
Myocardial Reperfusion Injury inferred via Estradiol 16810080
Neovascularization, Pathologic inferred via Estradiol 17289903
Prostatic Neoplasms inferred via Estradiol 16740699
Breast Neoplasms inferred via Epirubicin 17388661, 12006526, 15093573, 18511948
Hodgkin Disease inferred via Epirubicin 18180244
Adenocarcinoma inferred via Doxorubicin 17418594
Bone Marrow Neoplasms inferred via Doxorubicin 14601052
Brain Neoplasms inferred via Doxorubicin 17150277
Breast Neoplasms inferred via Doxorubicin 15692762, 15939500, 17983394, 18628466, 16935488, 18234424, 15136595, 11325840, 16322301, 16096432, 15993339, 15634643, 15567936, 15994142, 15668708, 16264153, 17369602, 18382427, 16826403, 17426702
Carcinoid Tumor inferred via Doxorubicin 16051944
Carcinoma, Hepatocellular inferred via Doxorubicin 18059187, 16234567, 16023760, 17876044
Carcinoma, Renal Cell inferred via Doxorubicin 16201981
Cardiomyopathies inferred via Doxorubicin 16952015, 18627295, 15476868, 16269455, 16109756, 16242529, 16364871, 16651473, 17351982, 17131338, 16455267, 15505089, 16278810, 17329180, 17007740, 17382496, 17974986, 16731534, 17308081, 15811867
Cardiomyopathy, Dilated inferred via Doxorubicin 17334414, 16243910
Colorectal Neoplasms inferred via Doxorubicin 18259882
Drug Toxicity inferred via Doxorubicin 18602426
Endometrial Neoplasms inferred via Doxorubicin 17359293
Endomyocardial Fibrosis inferred via Doxorubicin 18037988
Glioblastoma inferred via Doxorubicin 17150277
Head and Neck Neoplasms inferred via Doxorubicin 15692506
Heart Diseases inferred via Doxorubicin 16707910, 16144979, 16879835, 16330681, 16244372, 16244371
Hemangiosarcoma inferred via Doxorubicin 15692506
Hepatitis, Toxic inferred via Doxorubicin 17416283
Hodgkin Disease inferred via Doxorubicin 17606976, 15147373, 18501091
Kidney Diseases inferred via Doxorubicin 16775033, 15369732
Kidney Failure inferred via Doxorubicin 17922066
Kidney Failure, Chronic inferred via Doxorubicin 16707910
Leukemia, Erythroblastic, Acute inferred via Doxorubicin 16085563
Liver Cirrhosis, Experimental inferred via Doxorubicin 16595196, 16439617
Liver Neoplasms, Experimental inferred via Doxorubicin 17085340, 16842330
Lung Neoplasms inferred via Doxorubicin 17418594
Lymphoma inferred via Doxorubicin 16098063
Lymphoma, Non-Hodgkin inferred via Doxorubicin 17654614
Lymphoma, T-Cell inferred via Doxorubicin 15621674
Mammary Neoplasms, Experimental inferred via Doxorubicin 15458769
Melanoma inferred via Doxorubicin 16827129
Mucositis inferred via Doxorubicin 17415656
Neoplasm Metastasis inferred via Doxorubicin 18259882
Nephrotic Syndrome inferred via Doxorubicin 15640375, 16889571
Neuroblastoma inferred via Doxorubicin 15555623
Osteosarcoma inferred via Doxorubicin 15930896
Phyllodes Tumor inferred via Doxorubicin 17983394
Prostatic Neoplasms inferred via Doxorubicin 15897917, 16868541, 18437689, 15749863, 16888761, 16729912
Sarcoma inferred via Doxorubicin 18313854, 17710206, 17203757, 15625365, 15675481, 16767912
Sarcoma, Ewing's inferred via Doxorubicin 14601052, 16326096
Sarcoma, Kaposi inferred via Doxorubicin 17846226
Skin Neoplasms inferred via Doxorubicin 15692506
Soft Tissue Neoplasms inferred via Doxorubicin 16767912, 15625365, 17203757
Thyroid Neoplasms inferred via Doxorubicin 17909728, 16010429
Urinary Bladder Neoplasms inferred via Doxorubicin 17653716
Ventricular Dysfunction, Left inferred via Doxorubicin 17334414, 16364871
Breast Neoplasms inferred via docetaxel 15692762, 15567936, 16264153, 18628466, 17369602
Melanoma inferred via docetaxel 12417787
Prostatic Neoplasms inferred via docetaxel 16644109, 16520278
Colonic Neoplasms inferred via Dexamethasone 15824018
Liver Cirrhosis, Experimental inferred via Dexamethasone 16718785
Lung Neoplasms inferred via Dexamethasone 15824018, 11195469
Multiple Myeloma inferred via Dexamethasone 15867202, 16118317, 15744524
Respiratory Distress Syndrome, Adult inferred via Dexamethasone 11700416
Cardiovascular Diseases inferred via daidzein 16332659
Diabetes Mellitus, Type 2 inferred via daidzein 16647724
Hypertension inferred via daidzein 17169123
Bone Marrow Neoplasms inferred via Dactinomycin 14601052
Sarcoma, Ewing's inferred via Dactinomycin 14601052
Hodgkin Disease inferred via Cytarabine 16200630
Gingival Hyperplasia inferred via Cyclosporine 8708960
Metal Metabolism, Inborn Errors inferred via Cyclosporine 16801185
Nephrosis, Lipoid inferred via Cyclosporine 17954296
Nephrotic Syndrome inferred via Cyclosporine 18481113
Psoriasis inferred via Cyclosporine 16882103
Arteriosclerosis inferred via Cyclophosphamide 15014928
Breast Neoplasms inferred via Cyclophosphamide 17388661, 18234424, 12006526, 16978400, 11325840, 18323546, 15093573, 15136595
Carcinoma, Lewis Lung inferred via Cyclophosphamide 16152834
Carcinoma, Renal Cell inferred via Cyclophosphamide 16201981
Cystitis inferred via Cyclophosphamide 11948286, 10498854, 15643279, 12913760, 18483878, 18710439, 17979934, 15276878, 16413132, 18433785, 16651033, 16989017, 12388444, 17010015, 18295254, 16614059, 10700343
Diabetes Mellitus, Experimental inferred via Cyclophosphamide 11751995, 15331540, 10990075
Diabetes Mellitus, Type 1 inferred via Cyclophosphamide 18772604
Eosinophilia inferred via Cyclophosphamide 11006010
Gliosarcoma inferred via Cyclophosphamide 11389073
GLOBOZOOSPERMIA inferred via Cyclophosphamide 16517039
Graft vs Host Disease inferred via Cyclophosphamide 11014644, 15172196, 16376943
Hemophilia A inferred via Cyclophosphamide 11918545
Hepatic Veno-Occlusive Disease inferred via Cyclophosphamide 14986274
Hodgkin Disease inferred via Cyclophosphamide 17606976, 16135485
Infertility, Male inferred via Cyclophosphamide 16517039
Leukemia inferred via Cyclophosphamide 10602166
Leukemia, Lymphocytic, Chronic, B-Cell inferred via Cyclophosphamide 18587576, 17658394, 17296974, 18172266, 17802794, 17008537
Leukopenia inferred via Cyclophosphamide 10052129, 11830472
Lymphoma inferred via Cyclophosphamide 12854902
Lymphoma, B-Cell inferred via Cyclophosphamide 16675587
Lymphoma, Non-Hodgkin inferred via Cyclophosphamide 11911406
Melanoma, Experimental inferred via Cyclophosphamide 16388313
Neuroblastoma inferred via Cyclophosphamide 16115947, 15176712
Oligospermia inferred via Cyclophosphamide 16517039
Pancreatic Neoplasms inferred via Cyclophosphamide 11332152
Prostatic Neoplasms inferred via Cyclophosphamide 17136230
Pulmonary Fibrosis inferred via Cyclophosphamide 16636934
Scleroderma, Systemic inferred via Cyclophosphamide 16636934
Urinary Bladder Neoplasms inferred via Cyclophosphamide 14692829
Breast Neoplasms inferred via Curcumin 16243823
Inflammation inferred via Curcumin 16956363, 17151092
Leukemia-Lymphoma, Adult T-Cell inferred via Curcumin 16106398
Leukemia, T-Cell inferred via Curcumin 16106398
Liver Cirrhosis, Experimental inferred via Curcumin 18006644
Liver Diseases inferred via Curcumin 16956363
Lung Neoplasms inferred via Curcumin 16243823
Lymphoma, T-Cell inferred via Curcumin 16173963
Memory Disorders inferred via Curcumin 17263510
Muscular Atrophy, Spinal inferred via Curcumin 17962980
Respiratory Distress Syndrome, Adult inferred via Curcumin 10666014
Adenocarcinoma inferred via Cisplatin 11798837
Bone Marrow Neoplasms inferred via Cisplatin 14601052
Breast Neoplasms inferred via Cisplatin 18382427
Colorectal Neoplasms inferred via Cisplatin 15273666
Hodgkin Disease inferred via Cisplatin 16170182, 16200630
Kidney Failure, Acute inferred via Cisplatin 12690470
Lung Neoplasms inferred via Cisplatin 11798837, 17225452
Melanoma inferred via Cisplatin 16809738, 17023156, 18176117, 18505091, 17761969, 12883367, 12393984, 12374674, 18332650, 15577323, 16432458, 16248763
Melanoma, Amelanotic inferred via Cisplatin 15990972
Neoplasms inferred via Cisplatin 16773208
Ovarian Neoplasms inferred via Cisplatin 17225452
Sarcoma, Ewing's inferred via Cisplatin 14601052
Testicular Neoplasms inferred via Cisplatin 17225452
Urinary Bladder Neoplasms inferred via Cisplatin 12973940, 17225452
Vaginal Neoplasms inferred via Cisplatin 15577323
Colonic Neoplasms inferred via cinnamic aldehyde 16343908, 17510524
Dermatitis, Allergic Contact inferred via cinnamic aldehyde 11042091
Lipidoses inferred via chlorcyclizine 15342952
Lymphoma inferred via Chlorambucil 10745627
Brain Neoplasms inferred via Carmustine 16187019
Glioblastoma inferred via Carmustine 16187019
Melanoma inferred via Carmustine 12393984
Carbon Tetrachloride Poisoning inferred via Carbon Tetrachloride 16192424, 16227642, 16124888, 15700767, 16050911, 16097048, 16011737, 10355542, 15673190
Fatty Liver inferred via Carbon Tetrachloride 16045604, 15959796, 12795759, 61145, 12631006, 17595544, 16239168
Hepatitis, Toxic inferred via Carbon Tetrachloride 17522070, 15027814, 15968718, 16227642, 15998439, 11566570, 16177239
Hyperbilirubinemia inferred via Carbon Tetrachloride 16899240
Liver Cirrhosis inferred via Carbon Tetrachloride 17174718, 16943688, 16221502, 16239168, 17334410
Liver Cirrhosis, Experimental inferred via Carbon Tetrachloride 16192424, 16116963, 15925388, 17525996, 17976157, 17557913, 17805973, 16248980, 18156304, 17721639, 18277467, 18205269, 14716496, 15730626, 12632514, 15052691, 12632512, 17766677, 17944888, 18395914, 18279442, 16027843, 15996030, 16033810, 17565644, 17869086, 17708605, 18006644, 18481824, 15057751, 12586293, 18054572, 10355542, 16011737, 18251166, 17823541, 12667390, 14748882, 13678700, 15818738, 17631135, 16097048, 15673190, 12649538, 16136751, 17481882, 17900296, 15123356, 18339082, 18429990, 12546737, 18418968, 12666154, 18412020, 17714472, 14512876, 12609069, 18166357, 17922224, 18420326, 15876570, 12445421, 16015684, 12741479, 14724832, 18472094, 15931870, 17698563, 15893842, 12958196, 17640975, 18376398, 12389079, 18187930, 18210741, 12445418, 15959796, 12898905, 18317297, 17761835, 14620537, 18472332, 14716833, 16638106, 18395095
Liver Diseases inferred via Carbon Tetrachloride 16246199, 15830285, 16964402, 15720792, 17285989
Liver Failure inferred via Carbon Tetrachloride 15123358
Liver Failure, Acute inferred via Carbon Tetrachloride 14706259, 16899240
Liver Neoplasms, Experimental inferred via Carbon Tetrachloride 15583823
Kidney Diseases inferred via caffeic acid phenethyl ester 15369732
Leukemia, Promyelocytic, Acute inferred via caffeic acid phenethyl ester 16766008
Cell Transformation, Neoplastic inferred via Cadmium 17332340
Kidney Diseases inferred via Cadmium 16962696, 16322080
Prostatic Neoplasms inferred via Cadmium 17075824
Urinary Bladder Neoplasms inferred via Cacodylic Acid 15537745
Glioblastoma inferred via biochanin A 16598420
Prostatic Neoplasms inferred via biochanin A 12111696
Esophageal Neoplasms inferred via Benzo(a)pyrene 16530937
Lung Neoplasms inferred via Benzo(a)pyrene 17053015
Urinary Bladder Neoplasms inferred via Benzo(a)pyrene 17053015
Melanoma inferred via artesunate 16273263
Colonic Neoplasms inferred via arsenite 15037631
Lung Neoplasms inferred via arsenite 16809336
Neovascularization, Pathologic inferred via arsenite 15738583
Arsenic Poisoning inferred via Arsenic 16251483, 16835338, 12569548
Atherosclerosis inferred via Arsenic 12928151
Carcinoma, Basal Cell inferred via Arsenic 15504454
Carcinoma, Hepatocellular inferred via Arsenic 16507464
Carcinoma, Squamous Cell inferred via Arsenic 15504454
Cardiovascular Diseases inferred via Arsenic 15738583
Carotid Artery Diseases inferred via Arsenic 16973168
Foot Diseases inferred via Arsenic 6392382
Hypertension inferred via Arsenic 9931084, 11953799
Keratosis inferred via Arsenic 17050553, 12749816, 16930632
Leukemia, Promyelocytic, Acute inferred via Arsenic 17339181
Liver Diseases inferred via Arsenic 11134558
Liver Neoplasms inferred via Arsenic 16368122
Myocardial Ischemia inferred via Arsenic 15371236
Neural Tube Defects inferred via Arsenic 16620997
Neurogenic Inflammation inferred via Arsenic 17056641
Peripheral Vascular Diseases inferred via Arsenic 15371236, 16905509, 6392382
Prostatic Neoplasms inferred via Arsenic 16140617
Skin Diseases inferred via Arsenic 17050553, 16759981, 6392382, 16353154, 15952646
Skin Neoplasms inferred via Arsenic 16251483, 17050553, 15504454, 17029826
Urinary Bladder Neoplasms inferred via Arsenic 15987713, 11144890
Vascular Diseases inferred via Arsenic 17056641
Breast Neoplasms inferred via Apigenin 17132221, 16541309
Prostatic Neoplasms inferred via Apigenin 17132221
Leishmaniasis inferred via Antimony 15220340
Trypanosomiasis inferred via Antimony 15220340
Alzheimer Disease inferred via Acrolein 14715435, 15207723, 17570602
Arteriosclerosis inferred via Acrolein 15014928
Atherosclerosis inferred via Acrolein 17363696, 16037261, 16126721
Colorectal Neoplasms inferred via Acrolein 17597105
Kidney Diseases inferred via Acrolein 12488133
Kidney Failure inferred via Acrolein 12732208
Lung Diseases inferred via Acrolein 11504702
Melanoma, Experimental inferred via Acrolein 10803710
Neoplasms inferred via Acrolein 17329238
Nephritis inferred via Acrolein 12653641
Neurodegenerative Diseases inferred via Acrolein 11342003
Parkinson Disease inferred via Acrolein 17690948
Photosensitivity Disorders inferred via Acrolein 11550810
Stroke inferred via Acrolein 16269634
Carcinoma, Squamous Cell inferred via Acetylcysteine 17015178
Hepatitis, Toxic inferred via Acetaminophen 2444490, 17522070, 14986274, 16227642, 15968718, 16177239, 17562736, 16081117
Hyperalgesia inferred via Acetaminophen 16870215
Liver Failure, Acute inferred via Acetaminophen 16871587, 17185352
Pain inferred via Acetaminophen 16870215
Mammary Neoplasms, Experimental inferred via 5,6-dimethylxanthenoneacetic acid 16944150
Carcinoma, Squamous Cell inferred via 4-Nitroquinoline-1-oxide 16543248
Esophageal Neoplasms inferred via 4-Nitroquinoline-1-oxide 16543248
Tongue Neoplasms inferred via 4-Nitroquinoline-1-oxide 16543248
Amyotrophic Lateral Sclerosis inferred via 4-hydroxy-2-nonenal 10965797
Photosensitivity Disorders inferred via 4-hydroxy-2-nonenal 11550810
Alzheimer Disease inferred via 2-butenal 16538519
Adenoma inferred via 2-Acetylaminofluorene 10737359
Carcinoma, Hepatocellular inferred via 2-Acetylaminofluorene 10737359
Liver Neoplasms inferred via 2-Acetylaminofluorene 10737359, 18001218, 16273603, 14678523, 11376686, 10672840
Lung Neoplasms inferred via 2-Acetylaminofluorene 11376686
Urinary Bladder Neoplasms inferred via 2-Acetylaminofluorene 15867355, 15289314
Encephalomyelitis, Autoimmune, Experimental inferred via 15-deoxy-delta(12,14)-prostaglandin J2 16844232

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Yin JY, et al. (2009) "Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population." Pharmacogenet Genomics. 19(3):206-216. PMID:19214144
  2. [ + ] Rebecchi IM, et al. (2009) "ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment." Biochem Pharmacol. 77(1):66-75. PMID:18851956
  3. [ + ] Wan L, et al. (2009) "Characterization of the ATPase activity of a novel chimeric fusion protein consisting of the two nucleotide binding domains of MRP1." Arch Biochem Biophys. 485(2):102-108. PMID:19285030
  4. [ + ] Innocenti F, et al. (2009) "Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics." J Clin Oncol. 27(16):2604-2614. PMID:19349540
  5. [ + ] Jin J, et al. (2009) "The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor is a substrate for the multidrug resistance-related protein MRP1." Int J Cancer. 124(1):233-238. PMID:18924151
  6. [ + ] Corich L, et al. (2009) "The cytotoxic effect of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells is modulated by the expression level of MRP1 but not MDR1." Biochem J. 417(1):305-312. PMID:18713069
  7. [ + ] Abaan OD, et al. (2009) "Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients." Cancer Invest. 27(2):201-205. PMID:19235593
  8. [ + ] Tantisira KG, et al. (2009) "5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci." Pharmacogenet Genomics. 19(3):244-247. PMID:19214143
  9. [ + ] Wang H, et al. (2009) "Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export." Cancer. 115(3):595-607. PMID:19107762
  10. [ + ] Saito A, et al. (2009) "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." J Hum Genet. 54(6):317-323. PMID:19343046
  11. [ + ] Pham AN, et al. (2009) "Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins." Pharm Res. 26(4):936-945. PMID:19067123
  12. [ + ] Mookerjee Basu J, et al. (2008) "Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection." Antimicrob Agents Chemother. 52(3):1080-1093. PMID:18056276
  13. [ + ] Kamata S, et al. (2008) "Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas." Histopathology. 52(6):747-754. PMID:18439156
  14. [ + ] Sibhatu MB, et al. (2008) "Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane." Carcinogenesis. 29(4):807-815. PMID:18204073
  15. [ + ] Gazzin S, et al. (2008) "Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces." J Comp Neurol. 510(5):497-507. PMID:18680196
  16. [ + ] Mahjoubi F, et al. (2008) "MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients." Genet Mol Res. 7(4):1369-1374. PMID:19065772
  17. [ + ] Qin L, et al. (2008) "Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1." Biochemistry. 47(52):13952-13965. PMID:19063607
  18. [ + ] Letourneau IJ, et al. (2008) "Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter." Biochem Pharmacol. 75(8):1659-1669. PMID:18336795
  19. [ + ] Atalay C, et al. (2008) "Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer." J Chemother. 20(6):734-739. PMID:19129072
  20. [ + ] Aneja R, et al. (2008) "Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agent." Cancer Res. 68(5):1495-1503. PMID:18316614
  21. [ + ] Larbcharoensub N, et al. (2008) "Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy." Hum Pathol. 39(6):837-845. PMID:18400250
  22. [ + ] Ranganathan P, et al. (2008) "Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis." J Rheumatol. 35(4):572-579. PMID:18381794
  23. [ + ] Blokzijl H, et al. (2008) "Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease." J Biol Chem. 283(51):35630-35637. PMID:18838379
  24. [ + ] Warren RB, et al. (2008) "Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis." J Invest Dermatol. 128(8):1925-1929. PMID:18256692
  25. [ + ] Grant CE, et al. (2008) "Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)." Drug Metab Dispos. 36(12):2571-2581. PMID:18775981
  26. [ + ] Gradilone A, et al. (2008) "Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy." Curr Cancer Drug Targets. 8(5):414-420. PMID:18690847
  27. [ + ] de Figueiredo-Pontes LL, et al. (2008) "Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia." Cytometry B Clin Cytom. 74(3):163-168. PMID:18200595
  28. [ + ] Nabekura T, et al. (2008) "Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1." Biochem Biophys Res Commun. 369(2):363-368. PMID:18280247
  29. [ + ] DeGorter MK, et al. (2008) "Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1)." Biochem Biophys Res Commun. 365(1):29-34. PMID:17980150
  30. [ + ] Lu MC, et al. (2008) "Increased multidrug resistance-associated protein activity in mononuclear cells of patients with systemic lupus erythematosus." Clin Exp Rheumatol. 26(4):638-645. PMID:18799096
  31. [ + ] Sherbakova EA, et al. (2008) "[Role of PTEN protein in multidrug resistance of prostate cancer cells]" Mol Biol (Mosk). 42(3):487-493. PMID:18702307
  32. [ + ] Daood M, et al. (2008) "ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS." Neuropediatrics. 39(4):211-218. PMID:19165709
  33. [ + ] Fazlina N, et al. (2008) "Assessment of P-gp and MRP1 activities using MultiDrugQuant Assay Kit: a preliminary study of correlation between protein expressions and its functional activities in newly diagnosed acute leukaemia patients." Malays J Pathol. 30(2):87-93. PMID:19291917
  34. [ + ] Marchan R, et al. (2008) "Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release." Biochim Biophys Acta. 1778(10):2413-2420. PMID:18621020
  35. [ + ] Chang XB, et al. (2007) "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1." Cancer Metastasis Rev. 26(1):15-37. PMID:17295059
  36. [ + ] Yang Y, et al. (2007) "Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1." J Biol Chem. 282(12):8821-8830. PMID:17264072
  37. [ + ] Adachi T, et al. (2007) "Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress." J Exp Ther Oncol. 6(4):335-348. PMID:18038766
  38. [ + ] Tazzari PL, et al. (2007) "Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts." Leukemia. 21(3):427-438. PMID:17215852
  39. [ + ] Kourti M, et al. (2007) "Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia." Int J Hematol. 86(2):166-173. PMID:17875533
  40. [ + ] Janneh O, et al. (2007) "Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes." J Antimicrob Chemother. 60(5):987-993. PMID:17890284
  41. [ + ] Cerf E, et al. (2007) "Multidrug resistance protein 1 is not associated to detergent-resistant membranes." Biochem Biophys Res Commun. 355(4):1025-1030. PMID:17336270
  42. [ + ] Baran Y, et al. (2007) "Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance." Hematology. 12(6):511-517. PMID:17852453
  43. [ + ] Naramoto H, et al. (2007) "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines." Int J Oncol. 30(2):393-401. PMID:17203221
  44. [ + ] Marsh S, et al. (2007) "Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer." J Clin Oncol. 25(29):4528-4535. PMID:17925548
  45. [ + ] Letourneau IJ, et al. (2007) "Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function." Drug Metab Dispos. 35(8):1372-1379. PMID:17494643
  46. [ + ] Kamburoglu G, et al. (2007) "Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma." Ophthalmic Res. 39(4):191-197. PMID:17596751
  47. [ + ] Filipits M, et al. (2007) "Multidrug resistance proteins do not predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International Adjuvant Lung Cancer Trial Biologic Program." Clin Cancer Res. 13(13):3892-3898. PMID:17606722
  48. [ + ] Heffeter P, et al. (2007) "Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24)." Biochem Pharmacol. 73(12):1873-1886. PMID:17445775
  49. [ + ] Limtrakul P, et al. (2007) "Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin." Mol Cell Biochem. 296(1-2):85-95. PMID:16960658
  50. [ + ] Bobrowska-Hagerstrand M, et al. (2007) "Flow cytometric monitoring of multidrug drug resistance protein 1 (MRP1/ABCC1) -mediated transport of 2',7'-bis-(3-carboxypropyl)-5-(and-6)- carboxyfluorescein (BCPCF) into human erythrocyte membrane inside-out vesicles." Mol Membr Biol. 24(5-6):485-495. PMID:17710652