14-3-3epsilon | GeneID:42186 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 42186 Official Symbol 14-3-3epsilon
Locus Dmel_CG31196 Gene Type protein-coding
Synonyms 14-3-3; 14-3-3-e; 14-3-3e; CG31196; CT24092; D14-3-3e; D14-3-3epsilon; DmelCG31196; EK3-5; PAR5; Par-5; SR3-9; Su(Raf)3B; anon-WO0172774.141; anon-WO02059370.52; l(3)j2B10
Full Name N/A
Description CG31196 gene product from transcript CG31196-RA
Chromosome 90F10-90F10
Also Known As 14-3-3epsilon, isoform A; 14-3-3epsilon, isoform B; 14-3-3epsilon, isoform C; 14-3-3epsilon, isoform D; 14-3-3epsilon-PA; 14-3-3epsilon-PB; 14-3-3epsilon-PC; 14-3-3epsilon-PD; CG31196-PA; CG31196-PB; CG31196-PC; CG31196-PD; suppressor of Ras85D 3-9
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38223

ID Symbol Protein Species
GeneID:7531 YWHAE NP_006752.1 Homo sapiens
GeneID:22627 Ywhae NP_033562.2 Mus musculus
GeneID:29753 Ywhae NP_113791.1 Rattus norvegicus
GeneID:42186 14-3-3epsilon NP_732309.1 Drosophila melanogaster
GeneID:282125 YWHAE NP_776916.1 Bos taurus
GeneID:322060 ywhae1 NP_997770.1 Danio rerio
GeneID:417554 YWHAE NP_001006219.1 Gallus gallus
GeneID:454409 YWHAE XP_001153770.1 Pan troglodytes
GeneID:480645 YWHAE XP_854358.1 Canis lupus familiaris
GeneID:821060 GRF7 NP_566174.1 Arabidopsis thaliana
GeneID:831462 GRF5 NP_568325.1 Arabidopsis thaliana
GeneID:833836 GRF3 NP_568557.1 Arabidopsis thaliana
GeneID:1282015 AgaP_AGAP001151 XP_322009.2 Anopheles gambiae
GeneID:2542029 rad24 NP_594167.1 Schizosaccharomyces pombe
GeneID:2712618 NCU03300.1 XP_330736.1 Neurospora crassa
GeneID:4329775 Os02g0580300 NP_001047234.1 Oryza sativa
GeneID:4333880 Os03g0710800 NP_001051051.1 Oryza sativa
GeneID:4336066 Os04g0462500 NP_001053003.1 Oryza sativa
GeneID:4345634 Os08g0430500 NP_001061856.1 Oryza sativa
GeneID:5049025 MGG_13806 XP_001404258.1 Magnaporthe grisea

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005694 Component chromosome
GO:0005737 Component cytoplasm
GO:0045172 Component germline ring canal
GO:0005634 Component nucleus
GO:0019904 Function protein domain specific binding
GO:0008426 Function protein kinase C inhibitor activity
GO:0000077 Process DNA damage checkpoint
GO:0007294 Process germarium-derived oocyte fate determination
GO:0007444 Process imaginal disc development
GO:0007093 Process mitotic cell cycle checkpoint
GO:0046958 Process nonassociative learning
GO:0008103 Process oocyte microtubule cytoskeleton polarization
GO:0007265 Process Ras protein signal transduction
GO:0007088 Process regulation of mitosis
GO:0009605 Process response to external stimulus
GO:0009314 Process response to radiation
GO:0048190 Process wing disc dorsal/ventral pattern formation

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_169796 NP_732309
2 NM_169797 NP_732310
3 NM_169798 NP_732311
4 NM_169799 NP_732312

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
14-3-3zeta 14-3-3epsilon / 14-3-3zeta Phenotypic Enhancement Benton R (2002)
14-3-3zeta 14-3-3zeta / 14-3-3epsilon Phenotypic Enhancement Benton R (2002)
14-3-3zeta 14-3-3epsilon / 14-3-3zeta Phenotypic Enhancement Chang HC (1997)
14-3-3zeta 14-3-3zeta / 14-3-3epsilon Phenotypic Enhancement Chang HC (1997)
aop 14-3-3epsilon / aop Phenotypic Enhancement Karim FD (1996)
chico chico / 14-3-3epsilon Affinity Capture-MS Pflieger D (2007)
Dsor1 14-3-3epsilon / Dsor1 Phenotypic Enhancement Karim FD (1996)
Eip63E Eip63E / 14-3-3epsilon Two-hybrid Stanyon CA (2004)
N/A N/A / 14-3-3epsilon Two-hybrid Stanyon CA (2004)
par-1 14-3-3epsilon / par-1 Phenotypic Enhancement Benton R (2002)
par-1 par-1 / 14-3-3epsilon Phenotypic Enhancement Benton R (2002)
phl 14-3-3epsilon / phl Phenotypic Enhancement Chang HC (1997)
phl phl / 14-3-3epsilon Phenotypic Enhancement Chang HC (1997)
phl 14-3-3epsilon / phl Phenotypic Enhancement Dickson BJ (1996)
phl phl / 14-3-3epsilon Phenotypic Enhancement Dickson BJ (1996)
phl 14-3-3epsilon / phl Phenotypic Enhancement Karim FD (1996)
phl 14-3-3epsilon / phl Phenotypic Enhancement Li W (2000)
phl phl / 14-3-3epsilon Phenotypic Enhancement Li W (2000)
phl 14-3-3epsilon / phl Phenotypic Enhancement Therrien M (2000)
phl phl / 14-3-3epsilon Phenotypic Enhancement Therrien M (2000)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Enhancement Chang HC (1997)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Enhancement Karim FD (1996)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Enhancement Therrien M (2000)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Suppression Chang HC (1997)
Ras85D Ras85D / 14-3-3epsilon Phenotypic Suppression Chang HC (1997)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Suppression Karim FD (1996)
Ras85D Ras85D / 14-3-3epsilon Phenotypic Suppression Karim FD (1996)
Ras85D 14-3-3epsilon / Ras85D Phenotypic Suppression Therrien M (2000)
Ras85D Ras85D / 14-3-3epsilon Phenotypic Suppression Therrien M (2000)
tor 14-3-3epsilon / tor Phenotypic Suppression Li J (2003)
tor tor / 14-3-3epsilon Phenotypic Suppression Li J (2003)
Ubx Ubx / 14-3-3epsilon Reconstituted Complex Bondos SE (2006)
Ubx Ubx / 14-3-3epsilon Two-hybrid Bondos SE (2006)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Pflieger D, et al. (2008) "Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation." Mol Cell Proteomics. 7(2):326-346. PMID:17956857
  2. [ + ] Dong J, et al. (2007) "Elucidation of a universal size-control mechanism in Drosophila and mammals." Cell. 130(6):1120-1133. PMID:17889654
  3. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  4. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  5. [ + ] Bjorklund M, et al. (2006) "Identification of pathways regulating cell size and cell-cycle progression by RNAi." Nature. 439(7079):1009-1013. PMID:16496002
  6. [ + ] Shigenobu S, et al. (2006) "Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster." Proc Natl Acad Sci U S A. 103(37):13728-13733. PMID:16950879
  7. [ + ] Bondos SE, et al. (2006) "Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteins." Mol Cell Proteomics. 5(5):824-834. PMID:16455680
  8. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  9. [ + ] Teleman AA, et al. (2005) "Drosophila Melted modulates FOXO and TOR activity." Dev Cell. 9(2):271-281. PMID:16054033
  10. [ + ] Baas AF, et al. (2004) "LKB1 tumor suppressor protein: PARtaker in cell polarity." Trends Cell Biol. 14(6):312-319. PMID:15183188
  11. [ + ] Stanyon CA, et al. (2004) "A Drosophila protein-interaction map centered on cell-cycle regulators." Genome Biol. 5(12):R96. PMID:15575970
  12. [ + ] Huynh JR, et al. (2004) "The origin of asymmetry: early polarisation of the Drosophila germline cyst and oocyte." Curr Biol. 14(11):R438-R449. PMID:15182695
  13. [ + ] Li J, et al. (2003) "Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling." Genetics. 164(1):247-258. PMID:12750336
  14. [ + ] Ahringer J, et al. (2003) "Control of cell polarity and mitotic spindle positioning in animal cells." Curr Opin Cell Biol. 15(1):73-81. PMID:12517707
  15. [ + ] Chen HK, et al. (2003) "Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1." Cell. 113(4):457-468. PMID:12757707
  16. [ + ] Hacker U, et al. (2003) "piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila." Proc Natl Acad Sci U S A. 100(13):7720-7725. PMID:12802016
  17. [ + ] Benton R, et al. (2003) "Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells." Cell. 115(6):691-704. PMID:14675534
  18. [ + ] Guedes Sde M, et al. (2003) "Drosophila melanogaster larval hemolymph protein mapping." Biochem Biophys Res Commun. 312(3):545-554. PMID:14680800
  19. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  20. [ + ] Rebay I, et al. (2002) "Keeping the receptor tyrosine kinase signaling pathway in check: lessons from Drosophila." Dev Biol. 251(1):1-17. PMID:12413894
  21. [ + ] Benton R, et al. (2002) "Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation." Dev Cell. 3(5):659-671. PMID:12431373
  22. [ + ] Pellettieri J, et al. (2002) "Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences." Science. 298(5600):1946-1950. PMID:12471246
  23. [ + ] Johannes B, et al. (2002) "Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways." Mech Dev. 115(1-2):3-14. PMID:12049762
  24. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  25. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  26. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  27. [ + ] Su TT, et al. (2001) "Cell cycle roles for two 14-3-3 proteins during Drosophila development." J Cell Sci. 114(Pt 19):3445-3454. PMID:11682604
  28. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  29. [ + ] Walworth NC, et al. (2000) "Cell-cycle checkpoint kinases: checking in on the cell cycle." Curr Opin Cell Biol. 12(6):697-704. PMID:11063934
  30. [ + ] Therrien M, et al. (2000) "A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila." Genetics. 156(3):1231-1242. PMID:11063697
  31. [ + ] Li W, et al. (2000) "Identification of autosomal regions involved in Drosophila Raf function." Genetics. 156(2):763-774. PMID:11014822
  32. [ + ] Sekelsky JJ, et al. (2000) "DNA repair in Drosophila: insights from the Drosophila genome sequence." J Cell Biol. 150(2):F31-F36. PMID:10908583
  33. [ + ] Raabe T, et al. (2000) "The sevenless signaling pathway: variations of a common theme." Biochim Biophys Acta. 1496(2-3):151-163. PMID:10771085
  34. [ + ] Teeter K, et al. (2000) "Haplotype dimorphism in a SNP collection from Drosophila melanogaster." J Exp Zool. 288(1):63-75. PMID:10750054
  35. [ + ] Brodsky MH, et al. (2000) "mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development." Genes Dev. 14(6):666-678. PMID:10733527
  36. [ + ] Chen CK, et al. (1999) "Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors." Proc Natl Acad Sci U S A. 96(9):5055-5060. PMID:10220417
  37. [ + ] Baek KH, et al. (1999) "Signal transduction pathway for anterior-posterior development in Drosophila." J Biomed Sci. 6(5):314-319. PMID:10494038
  38. [ + ] Spradling AC, et al. (1999) "The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes." Genetics. 153(1):135-177. PMID:10471706
  39. [ + ] Tien AC, et al. (1999) "Dynamic expression and cellular localization of the drosophila 14-3-3epsilon during embryonic development." Mech Dev. 81(1-2):209-212. PMID:10330502
  40. [ + ] Chang HC, et al. (1997) "14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila." Genes Dev. 11(9):1132-1139. PMID:9159394
  41. [ + ] Rubin GM, et al. (1997) "Signal transduction downstream from Ras in Drosophila." Cold Spring Harb Symp Quant Biol. 62():347-352. PMID:9598368
  42. [ + ] Dickson BJ, et al. (1996) "Mutations Modulating Raf signaling in Drosophila eye development." Genetics. 142(1):163-171. PMID:8770593
  43. [ + ] Perrimon N, et al. (1996) "Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations." Genetics. 144(4):1681-1692. PMID:8978055
  44. [ + ] Karim FD, et al. (1996) "A screen for genes that function downstream of Ras1 during Drosophila eye development." Genetics. 143(1):315-329. PMID:8722784