5-HT2 | GeneID:40575 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 40575 Official Symbol 5-HT2
Locus Dmel_CG1056 Gene Type protein-coding
Synonyms 5-HT2Dro; 5-HT[[2Dro]]; 5-HT[[2]]; 5-HT[[2]]Dro; 5HT-R82A; 5HT-dro[[1]]; 5HT2-Dro; 5HT2Dro; 5HT[[2Dro]]; CG1056; Dm5HT2; DmelCG1056; d5-HT2; l(3)82CDb
Full Name N/A
Description Serotonin receptor 2
Chromosome 82C3-82D5
Also Known As 5-HT2-PA; 5-HT2-PB; 5-HT2-PC; 5-HT[[2]]Dro receptor; CG1056-PA; CG1056-PB; CG1056-PC; lethal (3) 82CDb; serotonin receptor 2, isoform A; serotonin receptor 2, isoform B; serotonin receptor 2, isoform C
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 117641

ID Symbol Protein Species
GeneID:40575 5-HT2 NP_001097684.1 Drosophila melanogaster
GeneID:798599 LOC798599 XP_001339040.2 Danio rerio

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0005886 Component plasma membrane
GO:0001587 Function 5-HT2 receptor activity
GO:0008227 Function amine receptor activity
GO:0016609 Function G-protein coupled serotonin receptor activity
GO:0004993 Function serotonin receptor activity
GO:0007377 Process germ-band extension
GO:0007186 Process G-protein coupled receptor protein signaling pathway
GO:0007210 Process serotonin receptor signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001104214 NP_001097684
2 NM_079499 NP_524223
3 NM_169011 NP_730859

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
Mob1 5-HT2 / Mob1 Two-hybrid Giot L (2003)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Schaerlinger B, et al. (2007) "Gain of affinity point mutation in the serotonin receptor gene 5-HT2Dro accelerates germband extension movements during Drosophila gastrulation." Dev Dyn. 236(4):991-999. PMID:17366631
  2. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  3. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  4. [ + ] Yuan Q, et al. (2006) "A sleep-promoting role for the Drosophila serotonin receptor 1A." Curr Biol. 16(11):1051-1062. PMID:16753559
  5. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  6. [ + ] Giot L, et al. (2003) "A protein interaction map of Drosophila melanogaster." Science. 302(5651):1727-1736. PMID:14605208
  7. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  8. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  9. [ + ] Radford JC, et al. (2002) "Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles." J Biol Chem. 277(41):38810-38817. PMID:12163486
  10. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  11. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  12. [ + ] Claridge-Chang A, et al. (2001) "Circadian regulation of gene expression systems in the Drosophila head." Neuron. 32(4):657-671. PMID:11719206
  13. [ + ] Tierney AJ, et al. (2001) "Structure and function of invertebrate 5-HT receptors: a review." Comp Biochem Physiol A Mol Integr Physiol. 128(4):791-804. PMID:11282322
  14. [ + ] Broeck JV, et al. (2001) "Insect G protein-coupled receptors and signal transduction." Arch Insect Biochem Physiol. 48(1):1-12. PMID:11519072
  15. [ + ] Blenau W, et al. (2001) "Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera." Arch Insect Biochem Physiol. 48(1):13-38. PMID:11519073
  16. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  17. [ + ] Miller WJ, et al. (2000) "Evolutionary dynamics of the SGM transposon family in the Drosophila obscura species group." Mol Biol Evol. 17(11):1597-1609. PMID:11070048
  18. [ + ] Brody T, et al. (2000) "Drosophila melanogaster G protein-coupled receptors." J Cell Biol. 150(2):F83-F88. PMID:10908591
  19. [ + ] Zeng ZB, et al. (2000) "Genetic architecture of a morphological shape difference between two Drosophila species." Genetics. 154(1):299-310. PMID:10628989
  20. [ + ] Colas JF, et al. (1999) "Maternal and zygotic control of serotonin biosynthesis are both necessary for Drosophila germband extension." Mech Dev. 87(1-2):67-76. PMID:10495272
  21. [ + ] Colas JF, et al. (1999) "Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila." Mech Dev. 87(1-2):77-91. PMID:10495273
  22. [ + ] Pebusque MJ, et al. (1998) "Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution." Mol Biol Evol. 15(9):1145-1159. PMID:9729879
  23. [ + ] Colas JF, et al. (1995) "Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation." Proc Natl Acad Sci U S A. 92(12):5441-5445. PMID:7777527
  24. [ + ] Hen R, et al. (1993) "Structural and functional conservation of serotonin receptors throughout evolution." EXS. 63():266-278. PMID:8422538