ABLIM1 | GeneID:3983 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 3983 Official Symbol ABLIM1
Locus RP11-317F20.1 Gene Type protein-coding
Synonyms ABLIM; DKFZp781D0148; FLJ14564; KIAA0059; LIMAB1; LIMATIN; MGC1224
Full Name actin binding LIM protein 1
Description actin binding LIM protein 1
Chromosome 10q25
Also Known As LIM actin-binding protein 1; OTTHUMP00000020530; OTTHUMP00000020531; OTTHUMP00000020536; actin-binding LIM protein 1; actin-binding double-zinc-finger protein
Summary This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 40994

ID Symbol Protein Species
GeneID:3983 ABLIM1 NP_002304.3 Homo sapiens
GeneID:41178 unc-115 NP_731391.1 Drosophila melanogaster
GeneID:181227 unc-115 NP_509702.3 Caenorhabditis elegans
GeneID:226251 Ablim1 NP_848803.2 Mus musculus
GeneID:261629 CG31352 NP_649930.4 Drosophila melanogaster
GeneID:307989 Ablim1 XP_217645.4 Rattus norvegicus
GeneID:450753 ABLIM1 XP_508051.2 Pan troglodytes
GeneID:477828 ABLIM1 XP_864927.1 Canis lupus familiaris
GeneID:504968 ABLIM1 XP_883296.2 Bos taurus
GeneID:1276123 AgaP_AGAP005425 XP_315432.2 Anopheles gambiae
GeneID:100003558 zgc:172321 NP_001107788.1 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab55410 ABLIM1 antibody (ab55410); Mouse monoclonal to ABLIM1
2 abnova H00003983-M01A ABLIM1 monoclonal antibody (M01A), clone 3A1; Mouse monoclonal antibody raised against a partial recombinant ABLIM1.
3 abnova H00003983-M01J ABLIM1 monoclonal antibody (M01J), clone 3A1; Mouse monoclonal antibody raised against a partial recombinant ABLIM1.
4 abnova H00003983-M06 ABLIM1 monoclonal antibody (M06), clone 2C6; Mouse monoclonal antibody raised against a partial recombinant ABLIM1.

Exon, Intron and UTRs

Exon, Intron and UTRs of ABLIM1 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ABLIM1 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0015629 Component actin cytoskeleton
GO:0005737 Component cytoplasm
GO:0003779 Function actin binding
GO:0046872 Function metal ion binding
GO:0005515 Function protein binding
GO:0008270 Function zinc ion binding
GO:0007010 Process cytoskeleton organization
GO:0009887 Process organ morphogenesis
GO:0007601 Process visual perception

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001003407  UCSC Browser NP_001003407 B3KVH2   Q5T6N3  
2 NM_001003408  UCSC Browser NP_001003408
3 NM_002313  UCSC Browser NP_002304
4 NM_006720  UCSC Browser NP_006711 O14639   Q5JVV2  

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
Calcitriol
  • Calcitriol results in increased expression of ABLIM1 mRNA
16002434
Estradiol
  • Estradiol affects the expression of ABLIM1 mRNA
14699072
Mifepristone
  • Mifepristone results in increased expression of ABLIM1 mRNA
17584828
Phenytoin
  • Phenytoin results in decreased expression of ABLIM1 mRNA
15136057
pirinixic acid
  • pirinixic acid results in increased expression of ABLIM1 mRNA
18301758, 17426115
resveratrol
  • resveratrol results in increased expression of ABLIM1 mRNA
12569576
tert-Butylhydroperoxide
  • tert-Butylhydroperoxide results in decreased expression of ABLIM1 mRNA
15336504
Tretinoin
  • Tretinoin results in decreased expression of ABLIM1 mRNA
16169686

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Alopecia inferred via Tretinoin 15955085
Arthritis, Experimental inferred via Tretinoin 16412693
Arthritis, Rheumatoid inferred via Tretinoin 16292516
Asthma inferred via Tretinoin 16456186
Barrett Esophagus inferred via Tretinoin 16935849
Blood Coagulation Disorders inferred via Tretinoin 16197459, 16206674
Breast Neoplasms inferred via Tretinoin 16873071, 16166294, 16443354
Bronchopulmonary Dysplasia inferred via Tretinoin 16813970
Carcinoma, Embryonal inferred via Tretinoin 16168501
Carcinoma, Squamous Cell inferred via Tretinoin 16096774, 16051514
Cataract inferred via Tretinoin 17460283
Cervical Intraepithelial Neoplasia inferred via Tretinoin 16129372
Choriocarcinoma inferred via Tretinoin 16461808
Colitis inferred via Tretinoin 17035595
Craniofacial Abnormalities inferred via Tretinoin 16925845
Endometrial Neoplasms inferred via Tretinoin 16569247
Eye Abnormalities inferred via Tretinoin 16938888
Glioblastoma inferred via Tretinoin 17312396
Head and Neck Neoplasms inferred via Tretinoin 16096774
Hearing Loss, Noise-Induced inferred via Tretinoin 16084493
Hyperalgesia inferred via Tretinoin 16870215
Hypereosinophilic Syndrome inferred via Tretinoin 16778211
Leukemia inferred via Tretinoin 17143497
Leukemia, Myeloid inferred via Tretinoin 16932348, 16482212
Leukemia, Myeloid, Acute inferred via Tretinoin 16294345
Leukemia, Promyelocytic, Acute inferred via Tretinoin 16891316, 12679006, 16935935, 17107899, 17217047, 17339181, 16140955, 16331271, 17294898, 17361223, 17368321, 17301526, 17506722, 16766008, 16788101, 15748426, 16823087
Liver Cirrhosis, Experimental inferred via Tretinoin 16248980, 18397230
Medulloblastoma inferred via Tretinoin 17453147
Melanoma inferred via Tretinoin 16752155
Meningomyelocele inferred via Tretinoin 16940565
Neoplasms inferred via Tretinoin 16946489, 16594593
Ovarian Neoplasms inferred via Tretinoin 16936753
Pain inferred via Tretinoin 16870215
Pancreatic Neoplasms inferred via Tretinoin 15976015
Pterygium inferred via Tretinoin 16723453
Rhabdomyosarcoma inferred via Tretinoin 16116481, 16283617
Skin Neoplasms inferred via Tretinoin 16467112
Stomach Neoplasms inferred via Tretinoin 17261132
Thyroid Neoplasms inferred via Tretinoin 17045167, 16026305
Tongue Neoplasms inferred via Tretinoin 16051514
Tuberculosis inferred via Tretinoin 16040207
Uterine Cervical Neoplasms inferred via Tretinoin 16129372
Uveal Neoplasms inferred via Tretinoin 16752155
Vitiligo inferred via Tretinoin 16761959
Wilms Tumor inferred via Tretinoin 16287080
Adenoma inferred via resveratrol 15688382
Alzheimer Disease inferred via resveratrol 16183991, 16162502
Arthritis, Experimental inferred via resveratrol 17115116
Atherosclerosis inferred via resveratrol 16873680, 17967414
Brain Ischemia inferred via resveratrol 17600658
Breast Neoplasms inferred via resveratrol 17651959, 16393696, 17534123
Carcinoma, Hepatocellular inferred via resveratrol 16227395
Carcinoma, Lewis Lung inferred via resveratrol 16675471
Carcinoma, Squamous Cell inferred via resveratrol 16227395
Cardiovascular Diseases inferred via resveratrol 15458977
Colitis inferred via resveratrol 16474422
Colonic Neoplasms inferred via resveratrol 16338953
Colorectal Neoplasms inferred via resveratrol 16550006
Diabetes Mellitus, Experimental inferred via resveratrol 16873680
Diabetic Nephropathies inferred via resveratrol 16286809
Edema inferred via resveratrol 8985016
Encephalomyelitis, Autoimmune, Experimental inferred via resveratrol 17872969
Enterocolitis, Necrotizing inferred via resveratrol 17923197
Herpes Simplex inferred via resveratrol 16876885
Hypercholesterolemia inferred via resveratrol 17188708
Hyperlipidemias inferred via resveratrol 16873680
Hypertrophy, Left Ventricular inferred via resveratrol 17488730
Infarction, Middle Cerebral Artery inferred via resveratrol 17600658
Inflammation inferred via resveratrol 16366677
Influenza, Human inferred via resveratrol 16624496
Kidney Failure, Acute inferred via resveratrol 16538975
Leukemia, Promyelocytic, Acute inferred via resveratrol 16087638
Lymphoma, B-Cell inferred via resveratrol 17088997
Lymphoma, Non-Hodgkin inferred via resveratrol 14749477
Mammary Neoplasms, Animal inferred via resveratrol 15688416
Mammary Neoplasms, Experimental inferred via resveratrol 8985016, 11606380
Melanoma inferred via resveratrol 17992120
Metabolic Diseases inferred via resveratrol 17112576
Multiple Myeloma inferred via resveratrol 14749477, 17935668, 17164350, 16490592, 16267019, 17049120
Muscular Atrophy, Spinal inferred via resveratrol 17962980
Myocardial Infarction inferred via resveratrol 17188708, 17125593, 16525036, 17015251, 16317513, 16456233
Myocardial Ischemia inferred via resveratrol 17125593, 17015251
Myocarditis inferred via resveratrol 17322642
Neoplasms, Experimental inferred via resveratrol 8985016
Neurodegenerative Diseases inferred via resveratrol 17652729
Neurogenic Inflammation inferred via resveratrol 17929310
Osteoporosis, Postmenopausal inferred via resveratrol 17513867
Prenatal Exposure Delayed Effects inferred via resveratrol 16679765
Prostatic Neoplasms inferred via resveratrol 17675339, 17718901, 17636462, 15767336, 17804756, 16731767
Renal Insufficiency, Chronic inferred via resveratrol 16325855
Reperfusion Injury inferred via resveratrol 17058453, 16317513, 17520802, 16314181, 15827377
Skin Neoplasms inferred via resveratrol 15837718, 8985016
STROKE, ISCHEMIC inferred via resveratrol 16321402
Tongue Neoplasms inferred via resveratrol 16227395
Uterine Cervical Neoplasms inferred via resveratrol 17473185
Uterine Neoplasms inferred via resveratrol 17044934
Ventricular Dysfunction, Left inferred via resveratrol 17488730
Edema inferred via pirinixic acid 12083418
Liver Neoplasms inferred via pirinixic acid 15890375
Abnormalities, Drug-Induced inferred via Phenytoin 3425630, 10563481
Atherosclerosis inferred via Phenytoin 15136057
Cleft Palate inferred via Phenytoin 2227380, 3877104, 10789828, 6862529, 6856622, 1687470
Congenital Abnormalities inferred via Phenytoin 10627286
Drug Eruptions inferred via Phenytoin 15024534
Epidermolysis Bullosa inferred via Phenytoin 6251365, 1399206
Epilepsies, Partial inferred via Phenytoin 17116037
Epilepsy inferred via Phenytoin 11434505
Fetal Death inferred via Phenytoin 10627286
Gingival Hyperplasia inferred via Phenytoin 9029455
Gingival Overgrowth inferred via Phenytoin 16390469, 14659971
Hyperhomocysteinemia inferred via Phenytoin 10459572
Liver Diseases inferred via Phenytoin 14986274
Myoclonic Epilepsies, Progressive inferred via Phenytoin 17484760
Myotonia Congenita inferred via Phenytoin 1896199
Osteomalacia inferred via Phenytoin 17016548
Pseudolymphoma inferred via Phenytoin 1419762, 12752131, 8603615
Endometriosis inferred via Mifepristone 16134523
Ovarian Neoplasms inferred via Mifepristone 16525653
Breast Neoplasms inferred via Estradiol 17289903, 18497071, 17018787, 17261762, 12948864, 14630087
Candidiasis, Vulvovaginal inferred via Estradiol 16111702
Carcinoma, Hepatocellular inferred via Estradiol 16924424
Herpes Genitalis inferred via Estradiol 15709030
Hot Flashes inferred via Estradiol 17088409
Insulin Resistance inferred via Estradiol 16393666, 16627594
Kidney Diseases inferred via Estradiol 15618244
Kidney Neoplasms inferred via Estradiol 15610895
Liver Cirrhosis, Experimental inferred via Estradiol 14716833, 14659978
Mammary Neoplasms, Experimental inferred via Estradiol 17203775, 11408345, 16891317, 11807958
Myocardial Reperfusion Injury inferred via Estradiol 16810080
Neovascularization, Pathologic inferred via Estradiol 17289903
Prostatic Neoplasms inferred via Estradiol 16740699
Breast Neoplasms inferred via Calcitriol 11237771
Carcinoma, Squamous Cell inferred via Calcitriol 11237771
Encephalomyelitis, Autoimmune, Experimental inferred via Calcitriol 15138306
Prostatic Hyperplasia inferred via Calcitriol 15572423
Prostatic Neoplasms inferred via Calcitriol 12479363, 16644109, 16289102

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
GOLGA2 GOLGA2 / ABLIM1 Two-hybrid Rual JF (2005)
HOOK2 ABLIM1 / HOOK2 Two-hybrid Rual JF (2005)
KCNJ12 KCNJ12 / ABLIM1 Affinity Capture-MS Leonoudakis D (2004)
KIAA1446 ABLIM1 / KIAA1446 Two-hybrid Rual JF (2005)
KRT15 KRT15 / ABLIM1 Two-hybrid Rual JF (2005)
LDOC1 ABLIM1 / LDOC1 Affinity Capture-Western Rual JF (2005)
LDOC1 ABLIM1 / LDOC1 Two-hybrid Rual JF (2005)
NDP52 ABLIM1 / NDP52 Two-hybrid Rual JF (2005)
SFN SFN / ABLIM1 Affinity Capture-MS Benzinger A (2005)
TRAF2 ABLIM1 / TRAF2 Two-hybrid Rual JF (2005)
TSC22D4 ABLIM1 / TSC22D4 Two-hybrid Rual JF (2005)
USHBP1 ABLIM1 / USHBP1 Two-hybrid Rual JF (2005)
VIM ABLIM1 / VIM Two-hybrid Rual JF (2005)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Olsen JV, et al. (2006) "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Cell. 127(3):635-648. PMID:17081983
  2. [ + ] Ficarro SB, et al. (2005) "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites." Rapid Commun Mass Spectrom. 19(1):57-71. PMID:15570572
  3. [ + ] Rual JF, et al. (2005) "Towards a proteome-scale map of the human protein-protein interaction network." Nature. 437(7062):1173-1178. PMID:16189514
  4. [ + ] Tao WA, et al. (2005) "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." Nat Methods. 2(8):591-598. PMID:16094384
  5. [ + ] Benzinger A, et al. (2005) "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer." Mol Cell Proteomics. 4(6):785-795. PMID:15778465
  6. [ + ] Rush J, et al. (2005) "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Nat Biotechnol. 23(1):94-101. PMID:15592455
  7. [ + ] Brill LM, et al. (2004) "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Anal Chem. 76(10):2763-2772. PMID:15144186
  8. [ + ] Ota T, et al. (2004) "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 36(1):40-45. PMID:14702039
  9. [ + ] Leonoudakis D, et al. (2004) "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins." J Biol Chem. 279(21):22331-22346. PMID:15024025
  10. [ + ] Beausoleil SA, et al. (2004) "Large-scale characterization of HeLa cell nuclear phosphoproteins." Proc Natl Acad Sci U S A. 101(33):12130-12135. PMID:15302935
  11. [ + ] Jin J, et al. (2004) "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization." Curr Biol. 14(16):1436-1450. PMID:15324660
  12. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  13. [ + ] Nakajima D, et al. (2002) "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." DNA Res. 9(3):99-106. PMID:12168954
  14. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  15. [ + ] Kim AC, et al. (1997) "Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers." Genomics. 46(2):291-293. PMID:9417918
  16. [ + ] Roof DJ, et al. (1997) "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein." J Cell Biol. 138(3):575-588. PMID:9245787
  17. [ + ] Bonaldo MF, et al. (1996) "Normalization and subtraction: two approaches to facilitate gene discovery." Genome Res. 6(9):791-806. PMID:8889548
  18. [ + ] Adams MD, et al. (1995) "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence." Nature. 377(6547 Suppl):3-174. PMID:7566098
  19. [ + ] Nomura N, et al. (1994) "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." DNA Res. 1(5):223-229. PMID:7584044