18w | GeneID:37277 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 37277 Official Symbol 18w
Locus Dmel_CG8896 Gene Type protein-coding
Synonyms 18W; CG8896; CT25100; DmelCG8896; l(2)00053; tlr; toll
Full Name N/A
Description 18 wheeler
Chromosome 56F8-56F8
Also Known As 18-wheeler; 18w-PA; CG8896-PA; Toll-2; toll like receptor; toll receptor; wheeler
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 119122

ID Symbol Protein Species
GeneID:37272 Toll-7 NP_523797.1 Drosophila melanogaster
GeneID:37277 18w NP_476814.1 Drosophila melanogaster

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0016021 Component integral to membrane
GO:0031224 Component intrinsic to membrane
GO:0005624 Component membrane fraction
GO:0005886 Component plasma membrane
GO:0005515 Function protein binding
GO:0004888 Function transmembrane receptor activity
GO:0009653 Process anatomical structure morphogenesis
GO:0019731 Process antibacterial humoral response
GO:0007155 Process cell adhesion
GO:0006952 Process defense response
GO:0048598 Process embryonic morphogenesis
GO:0006955 Process immune response
GO:0045087 Process innate immune response
GO:0007275 Process multicellular organismal development
GO:0007165 Process signal transduction

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_057466 NP_476814

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

NM_057466  

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  2. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  3. [ + ] Sandmann T, et al. (2007) "A core transcriptional network for early mesoderm development in Drosophila melanogaster." Genes Dev. 21(4):436-449. PMID:17322403
  4. [ + ] Pilot F, et al. (2006) "Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation." Development. 133(4):711-723. PMID:16421189
  5. [ + ] Lazzaro BP, et al. (2006) "Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria." Genetics. 174(3):1539-1554. PMID:16888344
  6. [ + ] Kleve CD, et al. (2006) "Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila." Dev Dyn. 235(7):1953-1961. PMID:16607637
  7. [ + ] Mackay TF, et al. (2005) "Genetics and genomics of Drosophila mating behavior." Proc Natl Acad Sci U S A. 102 Suppl 1():6622-6629. PMID:15851659
  8. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  9. [ + ] Mace KA, et al. (2005) "An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head." Science. 308(5720):381-385. PMID:15831751
  10. [ + ] Brennan CA, et al. (2004) "Drosophila: the genetics of innate immune recognition and response." Annu Rev Immunol. 22():457-483. PMID:15032585
  11. [ + ] Kearney JB, et al. (2004) "Gene expression profiling of the developing Drosophila CNS midline cells." Dev Biol. 275(2):473-492. PMID:15501232
  12. [ + ] McGraw LA, et al. (2004) "Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster." Curr Biol. 14(16):1509-1514. PMID:15324670
  13. [ + ] Moehring AJ, et al. (2004) "The quantitative genetic basis of male mating behavior in Drosophila melanogaster." Genetics. 167(3):1249-1263. PMID:15280239
  14. [ + ] Agaisse H, et al. (2004) "The roles of JAK/STAT signaling in Drosophila immune responses." Immunol Rev. 198():72-82. PMID:15199955
  15. [ + ] Solano PJ, et al. (2003) "Genome-wide identification of in vivo Drosophila Engrailed-binding DNA fragments and related target genes." Development. 130(7):1243-1254. PMID:12588842
  16. [ + ] Janssens S, et al. (2002) "A universal role for MyD88 in TLR/IL-1R-mediated signaling." Trends Biochem Sci. 27(9):474-482. PMID:12217523
  17. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  18. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  19. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  20. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  21. [ + ] Lavine MD, et al. (2002) "Insect hemocytes and their role in immunity." Insect Biochem Mol Biol. 32(10):1295-1309. PMID:12225920
  22. [ + ] Ligoxygakis P, et al. (2002) "Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila." EMBO Rep. 3(7):666-673. PMID:12101100
  23. [ + ] Imler JL, et al. (2001) "Toll receptors in innate immunity." Trends Cell Biol. 11(7):304-311. PMID:11413042
  24. [ + ] Kimbrell DA, et al. (2001) "The evolution and genetics of innate immunity." Nat Rev Genet. 2(4):256-267. PMID:11283698
  25. [ + ] Mushegian A, et al. (2001) "Evolutionary perspective on innate immune recognition." J Cell Biol. 155(5):705-710. PMID:11724812
  26. [ + ] Luo C, et al. (2000) "Independent evolution of Toll and related genes in insects and mammals." Immunogenetics. 51(2):92-98. PMID:10663571
  27. [ + ] Hedengren M, et al. (2000) "Expression and evolution of the Drosophila attacin/diptericin gene family." Biochem Biophys Res Commun. 279(2):574-581. PMID:11118328
  28. [ + ] Khush RS, et al. (2000) "Genes that fight infection: what the Drosophila genome says about animal immunity." Trends Genet. 16(10):442-449. PMID:11050330
  29. [ + ] Wasserman SA, et al. (2000) "Toll signaling: the enigma variations." Curr Opin Genet Dev. 10(5):497-502. PMID:10980426
  30. [ + ] Tauszig S, et al. (2000) "Toll-related receptors and the control of antimicrobial peptide expression in Drosophila." Proc Natl Acad Sci U S A. 97(19):10520-10525. PMID:10973475
  31. [ + ] Aderem A, et al. (2000) "Toll-like receptors in the induction of the innate immune response." Nature. 406(6797):782-787. PMID:10963608
  32. [ + ] Cox RT, et al. (2000) "A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog." Genetics. 155(4):1725-1740. PMID:10924470
  33. [ + ] Nappi AJ, et al. (2000) "Cytotoxicity and cytotoxic molecules in invertebrates." Bioessays. 22(5):469-480. PMID:10797487
  34. [ + ] Meister M, et al. (2000) "The antimicrobial host defense of Drosophila." Curr Top Microbiol Immunol. 248():17-36. PMID:10793472
  35. [ + ] Rubin GM, et al. (2000) "Comparative genomics of the eukaryotes." Science. 287(5461):2204-2215. PMID:10731134
  36. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  37. [ + ] Qureshi ST, et al. (1999) "Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes." Trends Genet. 15(8):291-294. PMID:10431187
  38. [ + ] Janeway CA Jr, et al. (1999) "Lipoproteins take their toll on the host." Curr Biol. 9(23):R879-R882. PMID:10607553
  39. [ + ] Spradling AC, et al. (1999) "The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes." Genetics. 153(1):135-177. PMID:10471706
  40. [ + ] Hoffmann JA, et al. (1999) "Phylogenetic perspectives in innate immunity." Science. 284(5418):1313-1318. PMID:10334979
  41. [ + ] Dushay MS, et al. (1998) "Drosophila immune responses as models for human immunity." Am J Hum Genet. 62(1):10-14. PMID:9443887
  42. [ + ] Mathey-Prevot B, et al. (1998) "Mammalian and Drosophila blood: JAK of all trades?" Cell. 92(6):697-700. PMID:9529244
  43. [ + ] Wu LP, et al. (1998) "Regulated nuclear import of Rel proteins in the Drosophila immune response." Nature. 392(6671):93-97. PMID:9510254
  44. [ + ] Williams MJ, et al. (1997) "The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense." EMBO J. 16(20):6120-6130. PMID:9321392
  45. [ + ] Botas J, et al. (1996) "Chromosomal binding sites of Ultrabithorax homeotic proteins." Mech Dev. 56(1-2):129-138. PMID:8798153
  46. [ + ] Mitcham JL, et al. (1996) "T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family." J Biol Chem. 271(10):5777-5783. PMID:8621445
  47. [ + ] Eldon E, et al. (1994) "The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll." Development. 120(4):885-899. PMID:7600965
  48. [ + ] Chiang C, et al. (1994) "Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila." Mech Dev. 47(3):225-239. PMID:7848870