5-HT1A | GeneID:37196 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 37196 Official Symbol 5-HT1A
Locus Dmel_CG16720 Gene Type protein-coding
Synonyms 5-HT-dro2A; 5-HT1ADro; 5-HT[[1ADro]]; 5HT-R2A; 5HT-dro2A; 5HT-drp[[2A]]; 5HT1A; 5HT[[1ADro]]; 5htdro2a; CG16720; DRO2A; Dm5HTdro2A; DmelCG16720; d5-HT1A
Full Name N/A
Description Serotonin receptor 1A
Chromosome 56B2-56B5
Also Known As 5-HT1A-PA; 5-HT1A-PB; CG16720-PA; CG16720-PB; serotonin receptor 1A, isoform A; serotonin receptor 1A, isoform B; serotonin receptor 2A; serotonin-receptor-2A
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 20240

ID Symbol Protein Species
GeneID:3352 HTR1D NP_000855.1 Homo sapiens
GeneID:15552 Htr1d NP_032335.2 Mus musculus
GeneID:25323 Htr1d NP_036984.1 Rattus norvegicus
GeneID:37196 5-HT1A NP_725849.1 Drosophila melanogaster
GeneID:175322 ser-4 NP_497452.1 Caenorhabditis elegans
GeneID:403963 HTR1D NP_001003280.1 Canis lupus familiaris
GeneID:407136 HTR1D XP_587002.1 Bos taurus
GeneID:469219 HTR1D XP_524604.1 Pan troglodytes
GeneID:556429 LOC556429 XP_684336.1 Danio rerio
GeneID:558369 LOC558369 XP_686665.1 Danio rerio
GeneID:769107 HTR1D XP_001232312.1 Gallus gallus
GeneID:1269968 GPR5HT1A XP_308623.2 Anopheles gambiae

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0005887 Component integral to plasma membrane
GO:0001586 Function 5-HT1 receptor activity
GO:0008227 Function amine receptor activity
GO:0016609 Function G-protein coupled serotonin receptor activity
GO:0004993 Function serotonin receptor activity
GO:0007208 Process activation of phospholipase C activity by serotonin receptor signaling pathway
GO:0007198 Process inhibition of adenylate cyclase activity by serotonin receptor signaling pathway
GO:0045187 Process regulation of circadian sleep/wake cycle, sleep
GO:0007210 Process serotonin receptor signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_057454 NP_476802
2 NM_166322 NP_725849

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  2. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  3. [ + ] Yuan Q, et al. (2006) "A sleep-promoting role for the Drosophila serotonin receptor 1A." Curr Biol. 16(11):1051-1062. PMID:16753559
  4. [ + ] Wheeler SR, et al. (2006) "Single-cell mapping of neural and glial gene expression in the developing Drosophila CNS midline cells." Dev Biol. 294(2):509-524. PMID:16631157
  5. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  6. [ + ] Kearney JB, et al. (2004) "Gene expression profiling of the developing Drosophila CNS midline cells." Dev Biol. 275(2):473-492. PMID:15501232
  7. [ + ] Kerr M, et al. (2004) "Cell-specific manipulation of second messengers; a toolbox for integrative physiology in Drosophila." Curr Biol. 14(16):1468-1474. PMID:15324663
  8. [ + ] Merlet I, et al. (2004) "Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG." Neuroimage. 22(2):886-896. PMID:15193619
  9. [ + ] Radford JC, et al. (2002) "Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles." J Biol Chem. 277(41):38810-38817. PMID:12163486
  10. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  11. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  12. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  13. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  14. [ + ] Shim K, et al. (2001) "The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis." Development. 128(23):4923-4933. PMID:11731471
  15. [ + ] Tierney AJ, et al. (2001) "Structure and function of invertebrate 5-HT receptors: a review." Comp Biochem Physiol A Mol Integr Physiol. 128(4):791-804. PMID:11282322
  16. [ + ] Blenau W, et al. (2001) "Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera." Arch Insect Biochem Physiol. 48(1):13-38. PMID:11519073
  17. [ + ] Claridge-Chang A, et al. (2001) "Circadian regulation of gene expression systems in the Drosophila head." Neuron. 32(4):657-671. PMID:11719206
  18. [ + ] Brody T, et al. (2000) "Drosophila melanogaster G protein-coupled receptors." J Cell Biol. 150(2):F83-F88. PMID:10908591
  19. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  20. [ + ] Prokop A, et al. (1999) "Integrating bits and pieces: synapse structure and formation in Drosophila embryos." Cell Tissue Res. 297(2):169-186. PMID:10470487
  21. [ + ] Hita MT, et al. (1999) "Genetic localization of a Drosophila melanogaster resistance gene to a parasitoid wasp and physical mapping of the region." Genome Res. 9(5):471-481. PMID:10330127
  22. [ + ] Han KA, et al. (1998) "A novel octopamine receptor with preferential expression in Drosophila mushroom bodies." J Neurosci. 18(10):3650-3658. PMID:9570796
  23. [ + ] Pebusque MJ, et al. (1998) "Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution." Mol Biol Evol. 15(9):1145-1159. PMID:9729879
  24. [ + ] Feng G, et al. (1996) "Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster." J Neurosci. 16(12):3925-3933. PMID:8656286
  25. [ + ] Hen R, et al. (1993) "Structural and functional conservation of serotonin receptors throughout evolution." EXS. 63():266-278. PMID:8422538
  26. [ + ] Saudou F, et al. (1992) "A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns." EMBO J. 11(1):7-17. PMID:1310937
  27. [ + ] Buchner E, et al. (1991) "Genes expressed in the adult brain of Drosophila and effects of their mutations on behavior: a survey of transmitter- and second messenger-related genes." J Neurogenet. 7(4):153-192. PMID:1679453