5-HT1B | GeneID:37191 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 37191 Official Symbol 5-HT1B
Locus Dmel_CG15113 Gene Type protein-coding
Synonyms 5-HT-dro2B; 5-HT1BDro; 5-HT[[1BDro]]; 5-HT[[dro2B]]; 5HT-R2B; 5HT-dro2B; 5HT-dro[[2B]]; 5htdro2b; CG15113; DRO2B; Dm5HTdro2B; DmelCG15113; d5-HT1B
Full Name N/A
Description Serotonin receptor 1B
Chromosome 56B1-56B1
Also Known As 5-HT1B-PA; 5-HT1B-PB; CG15113-PA; CG15113-PB; drosophila serotonin receptor 1B; serotonin receptor 1B, isoform A; serotonin receptor 1B, isoform B; serotonin receptor 2B
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 114148

ID Symbol Protein Species
GeneID:37191 5-HT1B NP_523789.3 Drosophila melanogaster
GeneID:797538 LOC797538 XP_001921950.1 Danio rerio

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0005887 Component integral to plasma membrane
GO:0001586 Function 5-HT1 receptor activity
GO:0008227 Function amine receptor activity
GO:0016609 Function G-protein coupled serotonin receptor activity
GO:0004993 Function serotonin receptor activity
GO:0007208 Process activation of phospholipase C activity by serotonin receptor signaling pathway
GO:0009649 Process entrainment of circadian clock
GO:0007198 Process inhibition of adenylate cyclase activity by serotonin receptor signaling pathway
GO:0007210 Process serotonin receptor signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001144236 NP_001137708
2 NM_079065 NP_523789

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  2. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  3. [ + ] Yuan Q, et al. (2006) "A sleep-promoting role for the Drosophila serotonin receptor 1A." Curr Biol. 16(11):1051-1062. PMID:16753559
  4. [ + ] Yuan Q, et al. (2005) "Serotonin modulates circadian entrainment in Drosophila." Neuron. 47(1):115-127. PMID:15996552
  5. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  6. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  7. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  8. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  9. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  10. [ + ] Radford JC, et al. (2002) "Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles." J Biol Chem. 277(41):38810-38817. PMID:12163486
  11. [ + ] Tierney AJ, et al. (2001) "Structure and function of invertebrate 5-HT receptors: a review." Comp Biochem Physiol A Mol Integr Physiol. 128(4):791-804. PMID:11282322
  12. [ + ] Blenau W, et al. (2001) "Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera." Arch Insect Biochem Physiol. 48(1):13-38. PMID:11519073
  13. [ + ] Brody T, et al. (2000) "Drosophila melanogaster G protein-coupled receptors." J Cell Biol. 150(2):F83-F88. PMID:10908591
  14. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  15. [ + ] Prokop A, et al. (1999) "Integrating bits and pieces: synapse structure and formation in Drosophila embryos." Cell Tissue Res. 297(2):169-186. PMID:10470487
  16. [ + ] Hita MT, et al. (1999) "Genetic localization of a Drosophila melanogaster resistance gene to a parasitoid wasp and physical mapping of the region." Genome Res. 9(5):471-481. PMID:10330127
  17. [ + ] Han KA, et al. (1998) "A novel octopamine receptor with preferential expression in Drosophila mushroom bodies." J Neurosci. 18(10):3650-3658. PMID:9570796
  18. [ + ] Pebusque MJ, et al. (1998) "Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution." Mol Biol Evol. 15(9):1145-1159. PMID:9729879
  19. [ + ] Obosi LA, et al. (1996) "Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B." FEBS Lett. 381(3):233-236. PMID:8601462
  20. [ + ] Feng G, et al. (1996) "Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster." J Neurosci. 16(12):3925-3933. PMID:8656286
  21. [ + ] Hen R, et al. (1993) "Structural and functional conservation of serotonin receptors throughout evolution." EXS. 63():266-278. PMID:8422538
  22. [ + ] Saudou F, et al. (1992) "A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns." EMBO J. 11(1):7-17. PMID:1310937
  23. [ + ] Buchner E, et al. (1991) "Genes expressed in the adult brain of Drosophila and effects of their mutations on behavior: a survey of transmitter- and second messenger-related genes." J Neurogenet. 7(4):153-192. PMID:1679453