14-3-3zeta | GeneID:36059 | Drosophila melanogaster

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 36059 Official Symbol 14-3-3zeta
Locus Dmel_CG17870 Gene Type protein-coding
Synonyms 14-3-3; 2G1; 4-3-3 zeta; 5.11; 549; BEST:GH05075; CG17870; D14-3-3; D14-3-3zeta; DmelCG17870; K; PAR5; Par-5; l(2)07103; l(2)46CFe; l(2)46Ee; leo
Full Name N/A
Description CG17870 gene product from transcript CG17870-RB
Chromosome 46E6-46E8
Also Known As 14-3-3zeta, isoform A; 14-3-3zeta, isoform B; 14-3-3zeta, isoform C; 14-3-3zeta, isoform D; 14-3-3zeta, isoform E; 14-3-3zeta, isoform F; 14-3-3zeta, isoform G; 14-3-3zeta, isoform H; 14-3-3zeta, isoform I; 14-3-3zeta, isoform J; 14-3-3zeta-PA; 14-3-3zeta-PB; 14-3-3zeta-PC; 14-3-3zeta-PD; 14-3-3zeta-PE; 14-3-3zeta-PF; 14-3-3zeta-PG; 14-3-3zeta-PH; 14-3-3zeta-PI; 14-3-3zeta-PJ; CG17870-PA; CG17870-PB; CG17870-PC; CG17870-PD; CG17870-PE; CG17870-PF; CG17870-PG; CG17870-PH; CG17870-PI; CG17870-PJ; D14 3 3 protein; Leonardo-13-3-3; complementation group K; leonardo; leonardo 14-3-3
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 56528

ID Symbol Protein Species
GeneID:7534 YWHAZ NP_003397.1 Homo sapiens
GeneID:22631 Ywhaz NP_035870.1 Mus musculus
GeneID:25578 Ywhaz NP_037143.2 Rattus norvegicus
GeneID:36059 14-3-3zeta NP_995792.1 Drosophila melanogaster
GeneID:178113 par-5 NP_502235.1 Caenorhabditis elegans
GeneID:181348 ftt-2 NP_509939.1 Caenorhabditis elegans
GeneID:287022 YWHAZ NP_777239.1 Bos taurus
GeneID:335195 ywhaqb NP_958892.1 Danio rerio
GeneID:399487 ywhaqa NP_958921.1 Danio rerio
GeneID:425619 RCJMB04_11l21 NP_001026514.1 Gallus gallus
GeneID:472830 YWHAZ XP_528202.2 Pan troglodytes
GeneID:475864 YWHAZ XP_533072.2 Canis lupus familiaris
GeneID:1269582 AgaP_AGAP007643 XP_564583.1 Anopheles gambiae

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0045172 Component germline ring canal
GO:0005634 Component nucleus
GO:0005515 Function protein binding
GO:0019904 Function protein domain specific binding
GO:0008426 Function protein kinase C inhibitor activity
GO:0016483 Function tryptophan hydroxylase activator activity
GO:0006588 Process activation of tryptophan 5-monooxygenase activity
GO:0008283 Process cell proliferation
GO:0007059 Process chromosome segregation
GO:0001751 Process compound eye photoreceptor cell differentiation
GO:0007294 Process germarium-derived oocyte fate determination
GO:0007611 Process learning or memory
GO:0045448 Process mitotic cell cycle, embryonic
GO:0008355 Process olfactory learning
GO:0008103 Process oocyte microtubule cytoskeleton polarization
GO:0007265 Process Ras protein signal transduction

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
14-3-3epsilon 14-3-3epsilon / 14-3-3zeta Phenotypic Enhancement Benton R (2002)
14-3-3epsilon 14-3-3zeta / 14-3-3epsilon Phenotypic Enhancement Benton R (2002)
14-3-3epsilon 14-3-3epsilon / 14-3-3zeta Phenotypic Enhancement Chang HC (1997)
14-3-3epsilon 14-3-3zeta / 14-3-3epsilon Phenotypic Enhancement Chang HC (1997)
CG8683 14-3-3zeta / CG8683 Two-hybrid Giot L (2003)
chico chico / 14-3-3zeta Affinity Capture-MS Pflieger D (2007)
csw 14-3-3zeta / csw Two-hybrid Giot L (2003)
faf 14-3-3zeta / faf Phenotypic Suppression Isaksson A (1997)
faf faf / 14-3-3zeta Phenotypic Suppression Isaksson A (1997)
ftz-f1 14-3-3zeta / ftz-f1 Two-hybrid Giot L (2003)
HDAC4 HDAC4 / 14-3-3zeta Two-hybrid Giot L (2003)
Idh 14-3-3zeta / Idh Two-hybrid Giot L (2003)
mei-P22 mei-P22 / 14-3-3zeta Two-hybrid Giot L (2003)
mRpS30 14-3-3zeta / mRpS30 Two-hybrid Giot L (2003)
N/A 14-3-3zeta / N/A Two-hybrid Giot L (2003)
N/A N/A / 14-3-3zeta Two-hybrid Giot L (2003)
Oatp26F 14-3-3zeta / Oatp26F Two-hybrid Giot L (2003)
PebIII PebIII / 14-3-3zeta Two-hybrid Giot L (2003)
phyl phyl / 14-3-3zeta Two-hybrid Giot L (2003)
RpL8 RpL8 / 14-3-3zeta Two-hybrid Giot L (2003)
RpLP1 14-3-3zeta / RpLP1 Two-hybrid Giot L (2003)
Sap-r Sap-r / 14-3-3zeta Two-hybrid Giot L (2003)
slo 14-3-3zeta / slo Reconstituted Complex Zhou Y (1999)
Slob 14-3-3zeta / Slob Affinity Capture-Western Zhou Y (1999)
Slob 14-3-3zeta / Slob Reconstituted Complex Zhou Y (1999)
sol sol / 14-3-3zeta Two-hybrid Giot L (2003)
Src42A 14-3-3zeta / Src42A Phenotypic Suppression Zhang Q (1999)
Src42A Src42A / 14-3-3zeta Phenotypic Suppression Zhang Q (1999)
Syx1A 14-3-3zeta / Syx1A Two-hybrid Giot L (2003)
Tektin-A 14-3-3zeta / Tektin-A Two-hybrid Giot L (2003)
Tfb2 14-3-3zeta / Tfb2 Two-hybrid Giot L (2003)
tor 14-3-3zeta / tor Phenotypic Suppression Li J (2003)
tor tor / 14-3-3zeta Phenotypic Suppression Li J (2003)
tor 14-3-3zeta / tor Phenotypic Suppression Li W (1997)
tor tor / 14-3-3zeta Phenotypic Suppression Li W (1997)
VhaAC39 14-3-3zeta / VhaAC39 Two-hybrid Giot L (2003)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Pflieger D, et al. (2008) "Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation." Mol Cell Proteomics. 7(2):326-346. PMID:17956857
  2. [ + ] Dong J, et al. (2007) "Elucidation of a universal size-control mechanism in Drosophila and mammals." Cell. 130(6):1120-1133. PMID:17889654
  3. [ + ] Hoskins RA, et al. (2007) "Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Science. 316(5831):1625-1628. PMID:17569867
  4. [ + ] Smith CD, et al. (2007) "The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Science. 316(5831):1586-1591. PMID:17569856
  5. [ + ] Bjorklund M, et al. (2006) "Identification of pathways regulating cell size and cell-cycle progression by RNAi." Nature. 439(7079):1009-1013. PMID:16496002
  6. [ + ] Yano M, et al. (2006) "A novel function of 14-3-3 protein: 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins." Mol Biol Cell. 17(11):4769-4779. PMID:16943323
  7. [ + ] Krupp JJ, et al. (2005) "Identification of genetic loci that interact with cut during Drosophila wing-margin development." Genetics. 170(4):1775-1795. PMID:15956666
  8. [ + ] Margulies C, et al. (2005) "Deconstructing memory in Drosophila." Curr Biol. 15(17):R700-R713. PMID:16139203
  9. [ + ] Muller D, et al. (2005) "Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster." Genetics. 171(3):1137-1152. PMID:16118195
  10. [ + ] Quesneville H, et al. (2005) "Combined evidence annotation of transposable elements in genome sequences." PLoS Comput Biol. 1(2):166-175. PMID:16110336
  11. [ + ] Zhu MY, et al. (2005) "A screen for genes that influence fibroblast growth factor signal transduction in Drosophila." Genetics. 170(2):767-777. PMID:15834142
  12. [ + ] Huynh JR, et al. (2004) "The origin of asymmetry: early polarisation of the Drosophila germline cyst and oocyte." Curr Biol. 14(11):R438-R449. PMID:15182695
  13. [ + ] Raabe T, et al. (2004) "Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila." Proc Natl Acad Sci U S A. 101(39):14276-14281. PMID:15375215
  14. [ + ] Collier LS, et al. (2004) "Drosophila Costal1 mutations are alleles of protein kinase A that modulate hedgehog signaling." Genetics. 167(2):783-796. PMID:15238528
  15. [ + ] Baas AF, et al. (2004) "LKB1 tumor suppressor protein: PARtaker in cell polarity." Trends Cell Biol. 14(6):312-319. PMID:15183188
  16. [ + ] Janody F, et al. (2004) "A mosaic genetic screen reveals distinct roles for trithorax and polycomb group genes in Drosophila eye development." Genetics. 166(1):187-200. PMID:15020417
  17. [ + ] Guedes Sde M, et al. (2003) "Drosophila melanogaster larval hemolymph protein mapping." Biochem Biophys Res Commun. 312(3):545-554. PMID:14680800
  18. [ + ] Brembs B, et al. (2003) "Operant conditioning in invertebrates." Curr Opin Neurobiol. 13(6):710-717. PMID:14662373
  19. [ + ] Giot L, et al. (2003) "A protein interaction map of Drosophila melanogaster." Science. 302(5651):1727-1736. PMID:14605208
  20. [ + ] Davis RJ, et al. (2003) "Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development." Dev Biol. 259(2):272-287. PMID:12871701
  21. [ + ] Chen HK, et al. (2003) "Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1." Cell. 113(4):457-468. PMID:12757707
  22. [ + ] Li J, et al. (2003) "Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling." Genetics. 164(1):247-258. PMID:12750336
  23. [ + ] Sathyanarayana P, et al. (2003) "Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling." Biochim Biophys Acta. 1640(1):77-84. PMID:12676357
  24. [ + ] Zhou Y, et al. (2003) "Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel." J Biol Chem. 278(12):10073-10080. PMID:12529354
  25. [ + ] Ahringer J, et al. (2003) "Control of cell polarity and mitotic spindle positioning in animal cells." Curr Opin Cell Biol. 15(1):73-81. PMID:12517707
  26. [ + ] Benton R, et al. (2003) "Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells." Cell. 115(6):691-704. PMID:14675534
  27. [ + ] Brody T, et al. (2002) "Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen." Mech Dev. 113(1):41-59. PMID:11900973
  28. [ + ] Hoskins RA, et al. (2002) "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Genome Biol. 3(12):RESEARCH0085. PMID:12537574
  29. [ + ] Kaminker JS, et al. (2002) "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Genome Biol. 3(12):RESEARCH0084. PMID:12537573
  30. [ + ] Misra S, et al. (2002) "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Genome Biol. 3(12):RESEARCH0083. PMID:12537572
  31. [ + ] Celniker SE, et al. (2002) "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Genome Biol. 3(12):RESEARCH0079. PMID:12537568
  32. [ + ] Benton R, et al. (2002) "Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation." Dev Cell. 3(5):659-671. PMID:12431373
  33. [ + ] Jauch E, et al. (2002) "In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta-subunit." Gene. 298(1):29-39. PMID:12406573
  34. [ + ] Pellettieri J, et al. (2002) "Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences." Science. 298(5600):1946-1950. PMID:12471246
  35. [ + ] Sokolowski MB, et al. (2001) "Drosophila: genetics meets behaviour." Nat Rev Genet. 2(11):879-890. PMID:11715043
  36. [ + ] Davis RL, et al. (2001) "Mushroom bodies, Ca(2+) oscillations, and the memory gene amnesiac." Neuron. 30(3):653-656. PMID:11430799
  37. [ + ] Roman G, et al. (2001) "Molecular biology and anatomy of Drosophila olfactory associative learning." Bioessays. 23(7):571-581. PMID:11462211
  38. [ + ] Philip N, et al. (2001) "Conditional rescue of olfactory learning and memory defects in mutants of the 14-3-3zeta gene leonardo." J Neurosci. 21(21):8417-8425. PMID:11606630
  39. [ + ] Su TT, et al. (2001) "Cell cycle roles for two 14-3-3 proteins during Drosophila development." J Cell Sci. 114(Pt 19):3445-3454. PMID:11682604
  40. [ + ] Waddell S, et al. (2001) "What can we teach Drosophila? What can they teach us?" Trends Genet. 17(12):719-726. PMID:11718926
  41. [ + ] Goldstein ES, et al. (2001) "A genetic analysis of the cytological region 46C-F containing the Drosophila melanogaster homolog of the jun proto-oncogene." Mol Genet Genomics. 266(4):695-700. PMID:11810242
  42. [ + ] Morley KI, et al. (2001) "The genetics of cognitive processes: candidate genes in humans and animals." Behav Genet. 31(6):511-531. PMID:11838530
  43. [ + ] Zars T, et al. (2000) "Behavioral functions of the insect mushroom bodies." Curr Opin Neurobiol. 10(6):790-795. PMID:11240291
  44. [ + ] Sekelsky JJ, et al. (2000) "DNA repair in Drosophila: insights from the Drosophila genome sequence." J Cell Biol. 150(2):F31-F36. PMID:10908583
  45. [ + ] Raabe T, et al. (2000) "The sevenless signaling pathway: variations of a common theme." Biochim Biophys Acta. 1496(2-3):151-163. PMID:10771085
  46. [ + ] Adams MD, et al. (2000) "The genome sequence of Drosophila melanogaster." Science. 287(5461):2185-2195. PMID:10731132
  47. [ + ] Li W, et al. (2000) "Identification of autosomal regions involved in Drosophila Raf function." Genetics. 156(2):763-774. PMID:11014822
  48. [ + ] Zhang Q, et al. (1999) "A genetic screen for modifiers of drosophila Src42A identifies mutations in Egfr, rolled and a novel signaling gene." Genetics. 151(2):697-711. PMID:9927462
  49. [ + ] Casci T, et al. (1999) "Sprouty, an intracellular inhibitor of Ras signaling." Cell. 96(5):655-665. PMID:10089881
  50. [ + ] Baek KH, et al. (1999) "Signal transduction pathway for anterior-posterior development in Drosophila." J Biomed Sci. 6(5):314-319. PMID:10494038