ABCB5 | GeneID:340273 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 340273 Official Symbol ABCB5
Locus N/A Gene Type protein-coding
Synonyms ABCB5alpha; ABCB5beta; EST422562
Full Name ATP-binding cassette, sub-family B (MDR/TAP), member 5
Description ATP-binding cassette, sub-family B (MDR/TAP), member 5
Chromosome 7p15.3
Also Known As ATP-binding cassette protein; ATP-binding cassette, sub-family B, member 5; P-glycoprotein ABCB5
Summary ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 83488

ID Symbol Protein Species
GeneID:77706 Abcb5 XP_001002680.2 Mus musculus
GeneID:314537 Abcb5 XP_234725.4 Rattus norvegicus
GeneID:340273 ABCB5 NP_848654.3 Homo sapiens
GeneID:482344 ABCB5 XP_539461.2 Canis lupus familiaris
GeneID:743269 ABCB5 XP_001152831.1 Pan troglodytes
GeneID:839687 PGP13 NP_174115.1 Arabidopsis thaliana
GeneID:839694 PGP14 NP_174122.1 Arabidopsis thaliana

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abgent AP6122a ABCB5 Antibody (N-term); Purified Rabbit Polyclonal Antibody (Pab)
2 acris AP09395PU-S ABCB5 (Internal); antibody Ab
3 acris AP13085PU-N ABCB5 (N-term); antibody Ab
4 acris AP16712PU-N ABCB5; antibody Ab
5 acris AP09395PU-N ABCB5 (Internal); antibody Ab

Exon, Intron and UTRs

Exon, Intron and UTRs of ABCB5 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ABCB5 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016021 Component integral to membrane
GO:0005886 Component plasma membrane
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0000166 Function nucleotide binding
GO:0006810 Process transport

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_178559  UCSC Browser NP_848654

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
Calcitriol
  • Calcitriol results in increased expression of ABCB5 mRNA
16002434
Doxorubicin
  • ABCB5 protein results in chemical resistance to Doxorubicin
  • ABCB5 protein results in increased secretion of Doxorubicin
15899824
Hydralazine
  • [Hydralazine co-treated with Valproic Acid] results in decreased expression of ABCB5 mRNA
17183730
Valproic Acid
  • [Hydralazine co-treated with Valproic Acid] results in decreased expression of ABCB5 mRNA
17183730

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Melanoma marker 15899824
Dystonia inferred via Valproic Acid 1851702
Fatty Liver inferred via Valproic Acid 14986274
Leukemia, Myeloid, Acute inferred via Valproic Acid 16294345
Migraine Disorders inferred via Valproic Acid 18765137, 18803445
Pseudolymphoma inferred via Valproic Acid 12752131
Seizures inferred via Valproic Acid 11738929
Unverricht-Lundborg Syndrome inferred via Valproic Acid 3119515
Hypertension, Pregnancy-Induced inferred via Hydralazine 16612254
Adenocarcinoma inferred via Doxorubicin 17418594
Bone Marrow Neoplasms inferred via Doxorubicin 14601052
Brain Neoplasms inferred via Doxorubicin 17150277
Breast Neoplasms inferred via Doxorubicin 15692762, 18628466, 16935488, 18234424, 15668708, 15136595, 11325840, 16322301, 16096432, 15993339, 15634643, 15567936, 15994142, 16264153, 17369602, 18382427, 16826403, 15939500, 17983394, 17426702
Carcinoid Tumor inferred via Doxorubicin 16051944
Carcinoma, Hepatocellular inferred via Doxorubicin 18059187, 16234567, 17876044, 16023760
Carcinoma, Renal Cell inferred via Doxorubicin 16201981
Cardiomyopathies inferred via Doxorubicin 16952015, 17974986, 16242529, 16364871, 16651473, 17351982, 17131338, 16455267, 18627295, 17329180, 16731534, 15505089, 16278810, 15476868, 16269455, 16109756, 17382496, 15811867, 17308081, 17007740
Cardiomyopathy, Dilated inferred via Doxorubicin 17334414, 16243910
Colorectal Neoplasms inferred via Doxorubicin 18259882
Drug Toxicity inferred via Doxorubicin 18602426
Endometrial Neoplasms inferred via Doxorubicin 17359293
Endomyocardial Fibrosis inferred via Doxorubicin 18037988
Glioblastoma inferred via Doxorubicin 17150277
Head and Neck Neoplasms inferred via Doxorubicin 15692506
Heart Diseases inferred via Doxorubicin 16707910, 16244371, 16879835, 16144979, 16244372, 16330681
Hemangiosarcoma inferred via Doxorubicin 15692506
Hepatitis, Toxic inferred via Doxorubicin 17416283
Hodgkin Disease inferred via Doxorubicin 17606976, 15147373, 18501091
Kidney Diseases inferred via Doxorubicin 16775033, 15369732
Kidney Failure inferred via Doxorubicin 17922066
Kidney Failure, Chronic inferred via Doxorubicin 16707910
Leukemia, Erythroblastic, Acute inferred via Doxorubicin 16085563
Liver Cirrhosis, Experimental inferred via Doxorubicin 16595196, 16439617
Liver Neoplasms, Experimental inferred via Doxorubicin 17085340, 16842330
Lung Neoplasms inferred via Doxorubicin 17418594
Lymphoma inferred via Doxorubicin 16098063
Lymphoma, Non-Hodgkin inferred via Doxorubicin 17654614
Lymphoma, T-Cell inferred via Doxorubicin 15621674
Mammary Neoplasms, Experimental inferred via Doxorubicin 15458769
Melanoma inferred via Doxorubicin 16827129
Mucositis inferred via Doxorubicin 17415656
Neoplasm Metastasis inferred via Doxorubicin 18259882
Nephrotic Syndrome inferred via Doxorubicin 15640375, 16889571
Neuroblastoma inferred via Doxorubicin 15555623
Osteosarcoma inferred via Doxorubicin 15930896
Phyllodes Tumor inferred via Doxorubicin 17983394
Prostatic Neoplasms inferred via Doxorubicin 15897917, 16729912, 16868541, 15749863, 18437689, 16888761
Sarcoma inferred via Doxorubicin 18313854, 17710206, 16767912, 17203757, 15625365, 15675481
Sarcoma, Ewing's inferred via Doxorubicin 14601052, 16326096
Sarcoma, Kaposi inferred via Doxorubicin 17846226
Skin Neoplasms inferred via Doxorubicin 15692506
Soft Tissue Neoplasms inferred via Doxorubicin 16767912, 17203757, 15625365
Thyroid Neoplasms inferred via Doxorubicin 17909728, 16010429
Urinary Bladder Neoplasms inferred via Doxorubicin 17653716
Ventricular Dysfunction, Left inferred via Doxorubicin 17334414, 16364871
Breast Neoplasms inferred via Calcitriol 11237771
Carcinoma, Squamous Cell inferred via Calcitriol 11237771
Encephalomyelitis, Autoimmune, Experimental inferred via Calcitriol 15138306
Prostatic Hyperplasia inferred via Calcitriol 15572423
Prostatic Neoplasms inferred via Calcitriol 12479363, 16289102, 16644109

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Frank NY, et al. (2009) "ABCB5 gene amplification in human leukemia cells." Leuk Res. 33(10):1303-1305. PMID:19477512
  2. [ + ] Schatton T, et al. (2008) "Identification of cells initiating human melanomas." Nature. 451(7176):345-349. PMID:18202660
  3. [ + ] Matalon ST, et al. (2008) "The Role of heat shock protein 27 in extravillous trophoblast differentiation." J Cell Biochem. 103(3):719-729. PMID:17661346
  4. [ + ] Chen KG, et al. (2005) "Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes." Pigment Cell Res. 18(2):102-112. PMID:15760339
  5. [ + ] Frank NY, et al. (2005) "ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma." Cancer Res. 65(10):4320-4333. PMID:15899824
  6. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  7. [ + ] Huang Y, et al. (2004) "Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance." Cancer Res. 64(12):4294-4301. PMID:15205344
  8. [ + ] Frank NY, et al. (2003) "Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter." J Biol Chem. 278(47):47156-47165. PMID:12960149
  9. [ + ] Scherer SW, et al. (2003) "Human chromosome 7: DNA sequence and biology." Science. 300(5620):767-772. PMID:12690205
  10. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  11. [ + ] Malorni W, et al. (1998) "Intracellular expression of P-170 glycoprotein in peripheral blood mononuclear cell subsets from healthy donors and HIV-infected patients." Haematologica. 83(1):13-20. PMID:9542318
  12. [ + ] Allikmets R, et al. (1996) "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database." Hum Mol Genet. 5(10):1649-1655. PMID:8894702