ACACB | GeneID:32 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 32 Official Symbol ACACB
Locus N/A Gene Type protein-coding
Synonyms ACC2; ACCB; HACC275
Full Name acetyl-Coenzyme A carboxylase beta
Description acetyl-Coenzyme A carboxylase beta
Chromosome 12q24.11
Also Known As acetyl-CoA carboxylase 2
Summary Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 74382

ID Symbol Protein Species
GeneID:32 ACACB NP_001084.3 Homo sapiens
GeneID:100705 Acacb NP_598665.1 Mus musculus
GeneID:116719 Acacb NP_446374.1 Rattus norvegicus
GeneID:515338 ACACB XP_873014.2 Bos taurus
GeneID:556236 LOC556236 XP_684081.3 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab31931 Acetyl Coenzyme A Carboxylase (phospho S79) antibody (ab31931); Rabbit polyclonal to Acetyl Coenzyme A Carboxylase (phospho S79)
2 abcam ab63531 Acetyl Coenzyme A Carboxylase antibody (ab63531); Rabbit polyclonal to Acetyl Coenzyme A Carboxylase
3 abcam ab63485 Acetyl Coenzyme A Carboxylase antibody (ab63485); Rabbit polyclonal to Acetyl Coenzyme A Carboxylase
4 abcam ab55177 Acetyl Coenzyme A Carboxylase (phospho S80) antibody (ab55177); Rabbit polyclonal to Acetyl Coenzyme A Carboxylase (phospho S80)
5 abcam ab53688 Acetyl Coenzyme A Carboxylase (phospho S80) antibody (ab53688); Rabbit polyclonal to Acetyl Coenzyme A Carboxylase (phospho S80)
6 abcam ab45174 Acetyl Coenzyme A Carboxylase antibody [EP687Y] (ab45174); Rabbit monoclonal [EP687Y] to Acetyl Coenzyme A Carboxylase
7 abnova H00000032-M01A ACACB monoclonal antibody (M01), clone 1C11; Mouse monoclonal antibody raised against a partial recombinant ACACB.
8 scbt ACACB ACACB Antibody / ACACB Antibodies;
9 sigma HPA006554 Anti-ACACB antibody produced in rabbit ;

Exon, Intron and UTRs

Exon, Intron and UTRs of ACACB Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ACACB Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005829 Component cytosol
GO:0012505 Component endomembrane system
GO:0005794 Component Golgi apparatus
GO:0016020 Component membrane
GO:0003989 Function acetyl-CoA carboxylase activity
GO:0005524 Function ATP binding
GO:0009374 Function biotin binding
GO:0004075 Function biotin carboxylase activity
GO:0016874 Function ligase activity
GO:0030145 Function manganese ion binding
GO:0046872 Function metal ion binding
GO:0000166 Function nucleotide binding
GO:0006633 Process fatty acid biosynthetic process
GO:0008152 Process metabolic process
GO:0046320 Process regulation of fatty acid oxidation

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001093  UCSC Browser NP_001084

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one
  • 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACB protein
16873680
AICA ribonucleotide
  • AICA ribonucleotide results in increased phosphorylation of ACACB protein
16873680
Dihydrotestosterone
  • Dihydrotestosterone results in decreased phosphorylation of ACACB protein
16990341
Metformin
  • Metformin results in increased phosphorylation of ACACB protein
16873680
perfluorooctanoic acid
  • perfluorooctanoic acid results in increased expression of ACACB mRNA
17681415
pirinixic acid
  • pirinixic acid results in increased expression of ACACB mRNA
18301758, 17426115
Tunicamycin
  • Tunicamycin results in decreased expression of ACACB mRNA
17127020
Zinc
  • Zinc results in increased expression of ACACB mRNA
17074742
Zinc Sulfate
  • Zinc Sulfate results in increased expression of ACACB mRNA
17074742

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Hepatolenticular Degeneration inferred via Zinc Sulfate 17063115
Acrodermatitis inferred via Zinc 17190629, 16889938, 17202136
Alzheimer Disease inferred via Zinc 17119284, 16410023, 16325427, 16580781
Anemia, Sickle Cell inferred via Zinc 16916123
Asthma inferred via Zinc 17085522
Brain Injuries inferred via Zinc 17109824
Carcinoma, Squamous Cell inferred via Zinc 16543248
Cardiovascular Diseases inferred via Zinc 16936243
Diabetes Mellitus inferred via Zinc 16479319
Esophageal Neoplasms inferred via Zinc 16543248
Gastritis inferred via Zinc 17241300
Growth Disorders inferred via Zinc 17217573
Heart Failure inferred via Zinc 17162251
Heart Injuries inferred via Zinc 17074742
Helicobacter Infections inferred via Zinc 17241300
Hepatolenticular Degeneration inferred via Zinc 17276780
Ischemia inferred via Zinc 16584753
Kidney Diseases inferred via Zinc 16960431
Kidney Failure, Chronic inferred via Zinc 16518626
Mammary Neoplasms, Experimental inferred via Zinc 12773700
Pre-Eclampsia inferred via Zinc 17114810
Prostatic Neoplasms inferred via Zinc 12429649, 16700911, 16606632, 16517595
Retinal Degeneration inferred via Zinc 16584753
Tongue Neoplasms inferred via Zinc 16543248
Edema inferred via pirinixic acid 12083418
Liver Neoplasms inferred via pirinixic acid 15890375
Edema inferred via perfluorooctanoic acid 17259670, 12083418
Hepatomegaly inferred via perfluorooctanoic acid 3609246
Hyperalgesia inferred via perfluorooctanoic acid 12083418
Inflammation inferred via perfluorooctanoic acid 12083418
Leydig Cell Tumor inferred via perfluorooctanoic acid 8812269
Liver Neoplasms inferred via perfluorooctanoic acid 14757943
Niemann-Pick Disease, Type C inferred via perfluorooctanoic acid 9802331
Prenatal Exposure Delayed Effects inferred via perfluorooctanoic acid 17132714
Diabetes Mellitus inferred via Metformin 17446233
Diabetic Angiopathies inferred via Metformin 16385087
Hyperandrogenism inferred via Metformin 15356085, 17062894
Insulin Resistance inferred via Metformin 17062894
Polycystic Ovary Syndrome inferred via Metformin 15356085, 17062894

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Madauss KP, et al. (2009) "The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist." Acta Crystallogr D Biol Crystallogr. 65(Pt 5):449-461. PMID:19390150
  2. [ + ] Ruano G, et al. (2009) "Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone." Clin Chim Acta. 400(1-2):48-55. PMID:18996102
  3. [ + ] Barbe L, et al. (2008) "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 7(3):499-508. PMID:18029348
  4. [ + ] Szabo de Edelenyi F, et al. (2008) "Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest." Genes Nutr. 3(3-4):173-176. PMID:19034549
  5. [ + ] Locke GA, et al. (2008) "Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate." Arch Biochem Biophys. 475(1):72-79. PMID:18455495
  6. [ + ] de Leon J, et al. (2008) "Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels." Schizophr Res. 98(1-3):40-46. PMID:18031993
  7. [ + ] Kim KW, et al. (2007) "Expression, purification, and characterization of human acetyl-CoA carboxylase 2." Protein Expr Purif. 53(1):16-23. PMID:17223360
  8. [ + ] Conde E, et al. (2007) "Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas." Hum Pathol. 38(9):1351-1360. PMID:17521700
  9. [ + ] Cheng D, et al. (2007) "Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes." Protein Expr Purif. 51(1):11-21. PMID:16854592
  10. [ + ] Oh SY, et al. (2005) "Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues." J Biol Chem. 280(7):5909-5916. PMID:15590647
  11. [ + ] Kahn BB, et al. (2005) "AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism." Cell Metab. 1(1):15-25. PMID:16054041
  12. [ + ] Ruderman N, et al. (2004) "AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome." Nat Rev Drug Discov. 3(4):340-351. PMID:15060529
  13. [ + ] Rosa G, et al. (2003) "Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects." Obes Res. 11(11):1306-1312. PMID:14627750
  14. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  15. [ + ] Wojtaszewski JF, et al. (2002) "Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise." Biochem Biophys Res Commun. 298(3):309-316. PMID:12413941
  16. [ + ] Schrauwen P, et al. (2002) "The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression." Diabetes. 51(7):2220-2226. PMID:12086953
  17. [ + ] Abu-Elheiga L, et al. (2000) "The subcellular localization of acetyl-CoA carboxylase 2." Proc Natl Acad Sci U S A. 97(4):1444-1449. PMID:10677481
  18. [ + ] Ullrich CK, et al. (1997) "Assignment of acetyl-CoA carboxylase-beta (ACACB) to human chromosome band 12q24.1 by in situ hybridization." Cytogenet Cell Genet. 77(3-4):176-177. PMID:9284908
  19. [ + ] Abu-Elheiga L, et al. (1997) "Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms." J Biol Chem. 272(16):10669-10677. PMID:9099716
  20. [ + ] Widmer J, et al. (1996) "Identification of a second human acetyl-CoA carboxylase gene." Biochem J. 316 ( Pt 3)():915-922. PMID:8670171
  21. [ + ] Ha J, et al. (1996) "Cloning of human acetyl-CoA carboxylase-beta and its unique features." Proc Natl Acad Sci U S A. 93(21):11466-11470. PMID:8876158