Abcc8 | GeneID:25559 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 25559 Official Symbol Abcc8
Locus N/A Gene Type protein-coding
Synonyms Sur; Sur1
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Chromosome 1q22
Also Known As ATP-binding cassette subfamily C (CFTR/MRP) member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; Sulfonylurea receptor
Summary binds sulfonylurea; subunit of the ATP-sensitive potassium channel K(ATP), which is composed of Sur1 and the inwardly rectifying K(+) channel subunit, Kir6.2 [RGD]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 68048

ID Symbol Protein Species
GeneID:6833 ABCC8 NP_000343.2 Homo sapiens
GeneID:20927 Abcc8 NP_035640.2 Mus musculus
GeneID:25559 Abcc8 NP_037171.1 Rattus norvegicus
GeneID:423072 ABCC8 XP_421005.2 Gallus gallus
GeneID:451056 ABCC8 XP_508310.2 Pan troglodytes
GeneID:485402 ABCC8 XP_542520.2 Canis lupus familiaris
GeneID:538996 ABCC8 XP_584132.3 Bos taurus
GeneID:553281 abcc8 XP_001920483.1 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab32844 SUR1 antibody (ab32844); Rabbit polyclonal to SUR1

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0008282 Component ATP-sensitive potassium channel complex
GO:0005886 Component plasma membrane
GO:0042383 Component sarcolemma
GO:0030672 Component synaptic vesicle membrane
GO:0005524 Function ATP binding
GO:0005267 Function potassium channel activity
GO:0008281 Function sulfonylurea receptor activity
GO:0019905 Function syntaxin binding
GO:0046676 Process negative regulation of insulin secretion
GO:0043268 Process positive regulation of potassium ion transport
GO:0042221 Process response to chemical stimulus
GO:0042493 Process response to drug
GO:0032868 Process response to insulin stimulus
GO:0032496 Process response to lipopolysaccharide
GO:0009268 Process response to pH
GO:0010043 Process response to zinc ion

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_013039  UCSC Browser NP_037171

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Pratt EB, et al. (2009) "Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure." J Biol Chem. 284(12):7951-7959. PMID:19151370
  2. [ + ] Vavaiya KV, et al. (2008) "Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol." J Mol Neurosci. 34(2):121-129. PMID:18084728
  3. [ + ] Fan X, et al. (2008) "Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?" Diabetes. 57(12):3327-3334. PMID:18776135
  4. [ + ] Jin JY, et al. (2007) "Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP." Pharmacol Res. 56(3):237-247. PMID:17656102
  5. [ + ] Guiot Y, et al. (2007) "Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas." Diabetologia. 50(9):1889-1899. PMID:17593344
  6. [ + ] de Wet H, et al. (2007) "Studies of the ATPase activity of the ABC protein SUR1." FEBS J. 274(14):3532-3544. PMID:17561960
  7. [ + ] Tammaro P, et al. (2007) "The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits." J Physiol. 581(Pt 3):1259-1269. PMID:17395632
  8. [ + ] Acosta-Martinez M, et al. (2007) "Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats." Am J Physiol Endocrinol Metab. 292(6):E1801-E1807. PMID:17311891
  9. [ + ] Heemskerk S, et al. (2007) "Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia." Pflugers Arch. 454(2):321-334. PMID:17285300
  10. [ + ] Ota M, et al. (2007) "Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells." Neurosci Lett. 412(3):254-258. PMID:17174476
  11. [ + ] Simard JM, et al. (2007) "Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury." J Clin Invest. 117(8):2105-2113. PMID:17657312
  12. [ + ] Simard JM, et al. (2006) "Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke." Nat Med. 12(4):433-440. PMID:16550187
  13. [ + ] Tammaro P, et al. (2005) "Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions." EMBO J. 24(13):2318-2330. PMID:15962003
  14. [ + ] Bancila V, et al. (2005) "Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel." J Biol Chem. 280(10):8793-8799. PMID:15613469
  15. [ + ] Morrissey A, et al. (2005) "Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature." BMC Physiol. 5(1):1. PMID:15647111
  16. [ + ] Mikhailov MV, et al. (2005) "3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1." EMBO J. 24(23):4166-4175. PMID:16308567
  17. [ + ] Pasyk EA, et al. (2004) "Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel." J Biol Chem. 279(6):4234-4240. PMID:14645230
  18. [ + ] Cui N, et al. (2004) "H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2." J Biol Chem. 279(51):53259-53265. PMID:15485808
  19. [ + ] Tagmose TM, et al. (2004) "Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release." J Med Chem. 47(12):3202-3211. PMID:15163199
  20. [ + ] Reimann F, et al. (2003) "Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population." Diabetologia. 46(2):241-249. PMID:12627323
  21. [ + ] Cartier EA, et al. (2003) "Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor." J Biol Chem. 278(9):7081-7090. PMID:12496311
  22. [ + ] Cao K, et al. (2002) "Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles." Biochem Biophys Res Commun. 296(2):463-469. PMID:12163042
  23. [ + ] Gros L, et al. (2002) "Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31." Br J Pharmacol. 137(1):98-106. PMID:12183335
  24. [ + ] Moritz W, et al. (2001) "Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells." Endocrinology. 142(1):129-138. PMID:11145575
  25. [ + ] Dorschner H, et al. (1999) "Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure." Mol Pharmacol. 55(6):1060-1066. PMID:10347249
  26. [ + ] Hirohashi T, et al. (1998) "Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats." Mol Pharmacol. 53(6):1068-1075. PMID:9614210
  27. [ + ] Nelson DA, et al. (1996) "The high-affinity sulfonylurea receptor: distribution, glycosylation, purification, and immunoprecipitation of two forms from endocrine and neuroendocrine cell lines." Biochemistry. 35(47):14793-14799. PMID:8942641
  28. [ + ] Thomas PM, et al. (1995) "Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy." Science. 268(5209):426-429. PMID:7716548
  29. [ + ] Aguilar-Bryan L, et al. (1995) "Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion." Science. 268(5209):423-426. PMID:7716547