alp2 | GeneID:2540936 | Schizosaccharomyces pombe

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2540936 Official Symbol alp2
Locus SPBC800.05c Gene Type protein-coding
Synonyms atb2; ban5; tub1
Full Name N/A
Description tubulin alpha 2
Chromosome N/A
Also Known As
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 69045

ID Symbol Protein Species
GeneID:22146 Tuba1c NP_033474.1 Mus musculus
GeneID:41183 alphaTub85E NP_524297.1 Drosophila melanogaster
GeneID:84790 TUBA1C NP_116093.1 Homo sapiens
GeneID:185538 tba-9 NP_508555.2 Caenorhabditis elegans
GeneID:300218 Tuba1c NP_001011995.1 Rattus norvegicus
GeneID:373080 tuba1 NP_919369.1 Danio rerio
GeneID:451876 TUBA1C XP_001158840.1 Pan troglodytes
GeneID:608138 TUBA1C XP_850665.1 Canis lupus familiaris
GeneID:812459 PFD1050w XP_001351526.1 Plasmodium falciparum
GeneID:813316 PFI0180w XP_001351911.1 Plasmodium falciparum
GeneID:827154 TUA6 NP_193232.1 Arabidopsis thaliana
GeneID:839405 TUA4 NP_171974.1 Arabidopsis thaliana
GeneID:841425 TUA2 NP_175423.1 Arabidopsis thaliana
GeneID:854889 TUB1 NP_013625.1 Saccharomyces cerevisiae
GeneID:2539864 nda2 NP_596774.1 Schizosaccharomyces pombe
GeneID:2540936 alp2 NP_595106.1 Schizosaccharomyces pombe
GeneID:2684823 MGG_06650 XP_370153.2 Magnaporthe grisea
GeneID:2711743 NCU09468.1 XP_329827.1 Neurospora crassa
GeneID:2892113 KLLA0C16874g XP_452955.1 Kluyveromyces lactis
GeneID:4333966 Os03g0726100 NP_001051132.1 Oryza sativa
GeneID:4350197 Os11g0247300 NP_001067613.1 Oryza sativa
GeneID:4622265 AGOS_AFR441C NP_985988.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0005874 Component microtubule
GO:0005634 Component nucleus
GO:0043234 Component protein complex
GO:0003924 Function GTPase activity
GO:0005525 Function GTP binding
GO:0046982 Function protein heterodimerization activity
GO:0005200 Function structural constituent of cytoskeleton
GO:0007163 Process establishment or maintenance of cell polarity
GO:0007018 Process microtubule-based movement
GO:0000226 Process microtubule cytoskeleton organization
GO:0048311 Process mitochondrion distribution
GO:0051258 Process protein polymerization

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001021013 NP_595106

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Kerres A, et al. (2007) "The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast." Mol Biol Cell. 18(7):2441-2454. PMID:17442892
  2. [ + ] Sandblad L, et al. (2006) "The Schizosaccharomyces pombe EB1 homolog Mal3p binds and stabilizes the microtubule lattice seam." Cell. 127(7):1415-1424. PMID:17190604
  3. [ + ] Aslett M, et al. (2006) "Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%." Yeast. 23(13):913-919. PMID:17072883
  4. [ + ] Matsuyama A, et al. (2006) "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Nat Biotechnol. 24(7):841-847. PMID:16823372
  5. [ + ] Asakawa K, et al. (2006) "The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint." Mol Biol Cell. 17(3):1421-1435. PMID:16394105
  6. [ + ] Weir BA, et al. (2004) "Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe." Mol Biol Cell. 15(4):1656-1665. PMID:14767070
  7. [ + ] Tange Y, et al. (2004) "Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe." Genetics. 167(3):1095-1107. PMID:15280226
  8. [ + ] Wood V, et al. (2002) "The genome sequence of Schizosaccharomyces pombe." Nature. 415(6874):871-880. PMID:11859360
  9. [ + ] Garcia MA, et al. (2001) "Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint." EMBO J. 20(13):3389-3401. PMID:11432827
  10. [ + ] Takeoka A, et al. (2000) "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction." J Cell Sci. 113 Pt 24():4557-4562. PMID:11082048
  11. [ + ] Radcliffe PA, et al. (1999) "Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast." Mol Biol Cell. 10(9):2987-3001. PMID:10473641
  12. [ + ] Bahler J, et al. (1998) "Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis." Genes Dev. 12(9):1356-1370. PMID:9573052
  13. [ + ] Vega LR, et al. (1998) "An alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteins." Mol Biol Cell. 9(9):2349-2360. PMID:9725898
  14. [ + ] Radcliffe P, et al. (1998) "Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants." Mol Biol Cell. 9(7):1757-1771. PMID:9658169
  15. [ + ] Yaffe MP, et al. (1996) "Microtubules mediate mitochondrial distribution in fission yeast." Proc Natl Acad Sci U S A. 93(21):11664-11668. PMID:8876193
  16. [ + ] Toda T, et al. (1984) "Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe." Cell. 37(1):233-242. PMID:6327053