alp12 | GeneID:2540582 | Schizosaccharomyces pombe

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2540582 Official Symbol alp12
Locus SPBC26H8.07c Gene Type protein-coding
Synonyms ben1; nda3
Full Name N/A
Description tubulin beta (PMID 6094012)
Chromosome N/A
Also Known As
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 68504

ID Symbol Protein Species
GeneID:10383 TUBB2C NP_006079.1 Homo sapiens
GeneID:37238 betaTub56D NP_523795.2 Drosophila melanogaster
GeneID:181170 tbb-4 NP_509585.1 Caenorhabditis elegans
GeneID:227613 Tubb2c NP_666228.1 Mus musculus
GeneID:296554 Tubb2c NP_954525.1 Rattus norvegicus
GeneID:417255 TUBB2C XP_415530.2 Gallus gallus
GeneID:465170 TUBB2C XP_001139047.1 Pan troglodytes
GeneID:491231 TUBB2C XP_848461.1 Canis lupus familiaris
GeneID:539149 TUBB2C NP_001029835.1 Bos taurus
GeneID:641421 zgc:123194 NP_001032487.1 Danio rerio
GeneID:838590 TUB5 NP_564101.1 Arabidopsis thaliana
GeneID:843911 TUB1 NP_177706.1 Arabidopsis thaliana
GeneID:850506 TUB2 NP_116616.1 Saccharomyces cerevisiae
GeneID:1271023 AgaP_AGAP010929 XP_309765.2 Anopheles gambiae
GeneID:2540582 alp12 NP_596650.1 Schizosaccharomyces pombe
GeneID:2674304 MGG_00604 XP_368640.1 Magnaporthe grisea
GeneID:2705277 NCU04054.1 XP_323373.1 Neurospora crassa
GeneID:2892769 KLLA0D05269g XP_453295.1 Kluyveromyces lactis
GeneID:4619626 AGOS_ACR225C NP_983627.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005829 Component cytosol
GO:0005874 Component microtubule
GO:0043234 Component protein complex
GO:0003924 Function GTPase activity
GO:0005525 Function GTP binding
GO:0005200 Function structural constituent of cytoskeleton
GO:0007163 Process establishment or maintenance of cell polarity
GO:0007018 Process microtubule-based movement
GO:0000226 Process microtubule cytoskeleton organization
GO:0051258 Process protein polymerization

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001022572 NP_596650

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAC21454   CAA21099   NP_596650   P05219   T40019  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Matsuyama A, et al. (2006) "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Nat Biotechnol. 24(7):841-847. PMID:16823372
  2. [ + ] Aslett M, et al. (2006) "Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%." Yeast. 23(13):913-919. PMID:17072883
  3. [ + ] Nakano K, et al. (2003) "The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast." Genes Cells. 8(4):357-370. PMID:12653963
  4. [ + ] Wood V, et al. (2002) "The genome sequence of Schizosaccharomyces pombe." Nature. 415(6874):871-880. PMID:11859360
  5. [ + ] Garcia MA, et al. (2001) "Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint." EMBO J. 20(13):3389-3401. PMID:11432827
  6. [ + ] Radcliffe PA, et al. (2000) "Characterisation of fission yeast alp11 mutants defines three functional domains within tubulin-folding cofactor B." Mol Gen Genet. 263(5):752-760. PMID:10905343
  7. [ + ] Radcliffe PA, et al. (2000) "The cofactor-dependent pathways for alpha- and beta-tubulins in microtubule biogenesis are functionally different in fission yeast." Genetics. 156(1):93-103. PMID:10978278
  8. [ + ] Li YC, et al. (2000) "Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation." Genetics. 156(3):995-1004. PMID:11063680
  9. [ + ] Doe CL, et al. (1998) "The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin." Nucleic Acids Res. 26(18):4222-4229. PMID:9722643
  10. [ + ] Hirata D, et al. (1998) "Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast." EMBO J. 17(3):658-666. PMID:9450991
  11. [ + ] Bahler J, et al. (1998) "Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis." Genes Dev. 12(9):1356-1370. PMID:9573052
  12. [ + ] He X, et al. (1998) "Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe." J Cell Sci. 111 ( Pt 12)():1635-1647. PMID:9601094
  13. [ + ] Radcliffe P, et al. (1998) "Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants." Mol Biol Cell. 9(7):1757-1771. PMID:9658169
  14. [ + ] Sawin KE, et al. (1998) "Regulation of cell polarity by microtubules in fission yeast." J Cell Biol. 142(2):457-471. PMID:9679144
  15. [ + ] West RR, et al. (1998) "cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe." Mol Biol Cell. 9(10):2839-2855. PMID:9763447
  16. [ + ] He X, et al. (1997) "The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex." Proc Natl Acad Sci U S A. 94(15):7965-7970. PMID:9223296
  17. [ + ] Javerzat JP, et al. (1996) "Fission yeast genes which disrupt mitotic chromosome segregation when overexpressed." Nucleic Acids Res. 24(23):4676-4683. PMID:8972853
  18. [ + ] Ekwall K, et al. (1996) "Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function." J Cell Sci. 109 ( Pt 11)():2637-2648. PMID:8937982
  19. [ + ] Hiraoka Y, et al. (1984) "The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis." Cell. 39(2 Pt 1):349-358. PMID:6094012
  20. [ + ] Umesono K, et al. (1983) "Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds." J Mol Biol. 168(2):271-284. PMID:6887245