alp4 | GeneID:2540392 | Schizosaccharomyces pombe

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2540392 Official Symbol alp4
Locus SPBC365.15 Gene Type protein-coding
Synonyms
Full Name N/A
Description gamma tubulin complex subunit Alp4
Chromosome N/A
Also Known As
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 55980

ID Symbol Protein Species
GeneID:10844 TUBGCP2 NP_006650.1 Homo sapiens
GeneID:32946 Grip84 NP_728264.1 Drosophila melanogaster
GeneID:74237 Tubgcp2 NP_598516.1 Mus musculus
GeneID:309098 Tubgcp2 XP_219470.3 Rattus norvegicus
GeneID:386975 tubgcp2 NP_956416.1 Danio rerio
GeneID:423673 TUBGCP2 NP_001006496.1 Gallus gallus
GeneID:480829 TUBGCP2 XP_537946.2 Canis lupus familiaris
GeneID:781376 TUBGCP2 XP_001249575.1 Bos taurus
GeneID:831607 AT5G17410 NP_850838.1 Arabidopsis thaliana
GeneID:1276259 AgaP_AGAP005575 XP_315581.2 Anopheles gambiae
GeneID:2540392 alp4 NP_596044.1 Schizosaccharomyces pombe
GeneID:2683251 MGG_07129 XP_367204.2 Magnaporthe grisea
GeneID:2706506 NCU05296.1 XP_324653.1 Neurospora crassa
GeneID:4336312 Os04g0501700 NP_001053231.1 Oryza sativa

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0032153 Component cell division site
GO:0005813 Component centrosome
GO:0005829 Component cytosol
GO:0000923 Component equatorial microtubule organizing center
GO:0000930 Component gamma-tubulin complex
GO:0005634 Component nucleus
GO:0005816 Component spindle pole body
GO:0005515 Function protein binding
GO:0000910 Process cytokinesis
GO:0031122 Process cytoplasmic microtubule organization
GO:0007163 Process establishment or maintenance of cell polarity
GO:0000086 Process G2/M transition of mitotic cell cycle
GO:0033566 Process gamma-tubulin complex localization
GO:0000216 Process M/G1 transition of mitotic cell cycle
GO:0034631 Process microtubule anchoring at spindle pole body
GO:0007020 Process microtubule nucleation
GO:0007094 Process mitotic cell cycle spindle assembly checkpoint
GO:0007091 Process mitotic metaphase/anaphase transition
GO:0030473 Process nuclear migration along microtubule
GO:0051225 Process spindle assembly

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001021954 NP_596044

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

BAA77269   CAB44767   NP_596044   Q9Y705   T40322   T43510  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Toya M, et al. (2007) "Gamma-tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast." Nat Cell Biol. 9(6):646-653. PMID:17486116
  2. [ + ] Aslett M, et al. (2006) "Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%." Yeast. 23(13):913-919. PMID:17072883
  3. [ + ] Masuda H, et al. (2006) "Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes." Genes Cells. 11(4):319-336. PMID:16611237
  4. [ + ] Aoki K, et al. (2006) "CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation." Curr Biol. 16(16):1627-1635. PMID:16920624
  5. [ + ] Mayer C, et al. (2006) "An extended anaphase signaling pathway for Mad2p includes microtubule organizing center proteins and multiple motor-dependent transitions." Cell Cycle. 5(13):1456-1463. PMID:16855399
  6. [ + ] Matsuyama A, et al. (2006) "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Nat Biotechnol. 24(7):841-847. PMID:16823372
  7. [ + ] Anders A, et al. (2006) "Noncore components of the fission yeast gamma-tubulin complex." Mol Biol Cell. 17(12):5075-5093. PMID:17021256
  8. [ + ] Samejima I, et al. (2005) "Fission yeast mto2p regulates microtubule nucleation by the centrosomin-related protein mto1p." Mol Biol Cell. 16(6):3040-3051. PMID:15659644
  9. [ + ] Janson ME, et al. (2005) "Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes." J Cell Biol. 169(2):297-308. PMID:15837798
  10. [ + ] Tange Y, et al. (2004) "Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe." Genetics. 167(3):1095-1107. PMID:15280226
  11. [ + ] Sawin KE, et al. (2004) "Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p." Curr Biol. 14(9):763-775. PMID:15120067
  12. [ + ] Venkatram S, et al. (2004) "Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function." Mol Biol Cell. 15(5):2287-2301. PMID:15004232
  13. [ + ] Wood V, et al. (2002) "The genome sequence of Schizosaccharomyces pombe." Nature. 415(6874):871-880. PMID:11859360
  14. [ + ] Fujita A, et al. (2002) "A fourth component of the fission yeast gamma-tubulin complex, Alp16, is required for cytoplasmic microtubule integrity and becomes indispensable when gamma-tubulin function is compromised." Mol Biol Cell. 13(7):2360-2373. PMID:12134075
  15. [ + ] Vardy L, et al. (2002) "The gamma-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast." Genes Cells. 7(4):365-373. PMID:11952833
  16. [ + ] Vardy L, et al. (2000) "The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint." EMBO J. 19(22):6098-6111. PMID:11080156
  17. [ + ] Radcliffe P, et al. (1998) "Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants." Mol Biol Cell. 9(7):1757-1771. PMID:9658169