alp14 | GeneID:2539497 | Schizosaccharomyces pombe

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2539497 Official Symbol alp14
Locus SPCC895.07 Gene Type protein-coding
Synonyms mtc1
Full Name N/A
Description Mad2-dependent spindle checkpoint component (PMID 11432827)
Chromosome N/A
Also Known As
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 48885

ID Symbol Protein Species
GeneID:536618 LOC536618 XP_616757.3 Bos taurus
GeneID:850734 STU2 NP_013146.1 Saccharomyces cerevisiae
GeneID:2539497 alp14 NP_588048.1 Schizosaccharomyces pombe
GeneID:2680966 MGG_13613 XP_365164.2 Magnaporthe grisea
GeneID:2705760 NCU04535.1 XP_323888.1 Neurospora crassa
GeneID:2893641 KLLA0E16379g XP_454685.1 Kluyveromyces lactis
GeneID:4619392 AGOS_ACL132C NP_983272.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0000777 Component condensed chromosome kinetochore
GO:0005829 Component cytosol
GO:0015630 Component microtubule cytoskeleton
GO:0005816 Component spindle pole body
GO:0008017 Function microtubule binding
GO:0005515 Function protein binding
GO:0008608 Process attachment of spindle microtubules to kinetochore
GO:0031122 Process cytoplasmic microtubule organization
GO:0007163 Process establishment or maintenance of cell polarity
GO:0007017 Process microtubule-based process
GO:0007094 Process mitotic cell cycle spindle assembly checkpoint
GO:0051225 Process spindle assembly

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001023040 NP_588048

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

BAA84527   CAA22843   NP_588048   O94534   T41645  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Kerres A, et al. (2007) "The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast." Mol Biol Cell. 18(7):2441-2454. PMID:17442892
  2. [ + ] Matsuyama A, et al. (2006) "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Nat Biotechnol. 24(7):841-847. PMID:16823372
  3. [ + ] Aslett M, et al. (2006) "Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%." Yeast. 23(13):913-919. PMID:17072883
  4. [ + ] Aoki K, et al. (2006) "CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation." Curr Biol. 16(16):1627-1635. PMID:16920624
  5. [ + ] Gard DL, et al. (2004) "MAPping the eukaryotic tree of life: structure, function, and evolution of the MAP215/Dis1 family of microtubule-associated proteins." Int Rev Cytol. 239():179-272. PMID:15464854
  6. [ + ] Sato M, et al. (2004) "Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation." Mol Biol Cell. 15(4):1609-1622. PMID:14742702
  7. [ + ] Yuasa T, et al. (2004) "An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation." Genes Cells. 9(11):1069-1082. PMID:15507118
  8. [ + ] Garcia MA, et al. (2002) "Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast." EMBO J. 21(22):6015-6024. PMID:12426374
  9. [ + ] Wood V, et al. (2002) "The genome sequence of Schizosaccharomyces pombe." Nature. 415(6874):871-880. PMID:11859360
  10. [ + ] Nakaseko Y, et al. (2001) "M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase." Curr Biol. 11(8):537-549. PMID:11369198
  11. [ + ] Garcia MA, et al. (2001) "Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint." EMBO J. 20(13):3389-3401. PMID:11432827
  12. [ + ] Radcliffe P, et al. (1998) "Identification of novel temperature-sensitive lethal alleles in essential beta-tubulin and nonessential alpha 2-tubulin genes as fission yeast polarity mutants." Mol Biol Cell. 9(7):1757-1771. PMID:9658169