ago1 | GeneID:2539403 | Schizosaccharomyces pombe

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2539403 Official Symbol ago1
Locus SPCC736.11 Gene Type protein-coding
Synonyms csp9
Full Name N/A
Description argonaute
Chromosome N/A
Also Known As
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 101355

ID Symbol Protein Species
GeneID:2539403 ago1 NP_587782.1 Schizosaccharomyces pombe
GeneID:2675789 MGG_11029 XP_359958.1 Magnaporthe grisea
GeneID:2714027 NCU09434.1 XP_332126.1 Neurospora crassa

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab18190 Ago1 antibody (ab18190); Rabbit polyclonal to Ago1
2 abcam ab43441 Ago1 antibody (ab43441); Mouse polyclonal to Ago1

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0033167 Component ARC complex
GO:0005721 Component centromeric heterochromatin
GO:0005829 Component cytosol
GO:0031934 Component mating-type region heterochromatin
GO:0005724 Component nuclear telomeric heterochromatin
GO:0030958 Component RITS complex
GO:0005515 Function protein binding
GO:0030702 Process chromatin silencing at centromere
GO:0030466 Process chromatin silencing at silent mating-type cassette
GO:0006348 Process chromatin silencing at telomere
GO:0031048 Process chromatin silencing by small RNA
GO:0007059 Process chromosome segregation
GO:0051570 Process regulation of histone H3-K9 methylation
GO:0016246 Process RNA interference
GO:0033168 Process RNA interference, conversion of ds siRNA to ss siRNA

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001022775 NP_587782

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

CAA19275   CAW52601   NP_587782   O74957   T41568  

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Till S, et al. (2007) "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain." Nat Struct Mol Biol. 14(10):897-903. PMID:17891150
  2. [ + ] Partridge JF, et al. (2007) "Functional separation of the requirements for establishment and maintenance of centromeric heterochromatin." Mol Cell. 26(4):593-602. PMID:17531816
  3. [ + ] Buker SM, et al. (2007) "Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast." Nat Struct Mol Biol. 14(3):200-207. PMID:17310250
  4. [ + ] Stoica C, et al. (2006) "Interactions between the RNA interference effector protein Ago1 and 14-3-3 proteins: consequences for cell cycle progression." J Biol Chem. 281(49):37646-37651. PMID:17043360
  5. [ + ] Irvine DV, et al. (2006) "Argonaute slicing is required for heterochromatic silencing and spreading." Science. 313(5790):1134-1137. PMID:16931764
  6. [ + ] Carmichael JB, et al. (2006) "RNA interference effector proteins localize to mobile cytoplasmic puncta in Schizosaccharomyces pombe." Traffic. 7(8):1032-1044. PMID:16734665
  7. [ + ] Matsuyama A, et al. (2006) "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Nat Biotechnol. 24(7):841-847. PMID:16823372
  8. [ + ] Schramke V, et al. (2005) "RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription." Nature. 435(7046):1275-1279. PMID:15965464
  9. [ + ] Motamedi MR, et al. (2004) "Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs." Cell. 119(6):789-802. PMID:15607976
  10. [ + ] Carmichael JB, et al. (2004) "ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe." Mol Biol Cell. 15(3):1425-1435. PMID:14699070
  11. [ + ] Verdel A, et al. (2004) "RNAi-mediated targeting of heterochromatin by the RITS complex." Science. 303(5658):672-676. PMID:14704433
  12. [ + ] Jia S, et al. (2004) "RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins." Science. 304(5679):1971-1976. PMID:15218150
  13. [ + ] Noma K, et al. (2004) "RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing." Nat Genet. 36(11):1174-1180. PMID:15475954
  14. [ + ] Volpe T, et al. (2003) "RNA interference is required for normal centromere function in fission yeast." Chromosome Res. 11(2):137-146. PMID:12733640
  15. [ + ] Volpe TA, et al. (2002) "Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi." Science. 297(5588):1833-1837. PMID:12193640
  16. [ + ] Wood V, et al. (2002) "The genome sequence of Schizosaccharomyces pombe." Nature. 415(6874):871-880. PMID:11859360
  17. [ + ] Ekwall K, et al. (1999) "Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation." Genetics. 153(3):1153-1169. PMID:10545449