Abcc2 | GeneID:25303 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 25303 Official Symbol Abcc2
Locus N/A Gene Type protein-coding
Synonyms Cmoat; Mrp2
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Chromosome 1q51
Also Known As Canalicular multispecific organic anion transporter; calicular multispecific organic anion transporter; multidrug resistance associated protein 2
Summary multispecific organic anion transporter; mutation may be responsible for conjugated hyperbilirubinemia in the TR- rat, which is a model for human Dubin-Johnson syndrome [RGD]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 91562

ID Symbol Protein Species
GeneID:25303 Abcc2 XP_577883.2 Rattus norvegicus
GeneID:4326284 Os01g0356000 NP_001043000.1 Oryza sativa


[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab15603 MRP2 antibody [M2III-5] (ab15603); Mouse monoclonal [M2III-5] to MRP2
2 abcam ab3373 MRP2 antibody [M2 III-6] (ab3373); Mouse monoclonal [M2 III-6] to MRP2
3 abcam ab50213 MRP2 antibody - Carboxyterminal end (ab50213); Rabbit polyclonal to MRP2 - Carboxyterminal end
4 sigma M8316 Anti-MRP2 antibody produced in rabbit ;

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016324 Component apical plasma membrane
GO:0016021 Component integral to membrane
GO:0005887 Component integral to plasma membrane
GO:0046581 Component intercellular canaliculus
GO:0016020 Component membrane
GO:0005624 Component membrane fraction
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0000166 Function nucleotide binding
GO:0008514 Function organic anion transmembrane transporter activity
GO:0005515 Function protein binding
GO:0005215 Function transporter activity
GO:0030644 Process cellular chloride ion homeostasis
GO:0006855 Process multidrug transport
GO:0015711 Process organic anion transport
GO:0015732 Process prostaglandin transport
GO:0046685 Process response to arsenic
GO:0042493 Process response to drug
GO:0043627 Process response to estrogen stimulus
GO:0009408 Process response to heat
GO:0031427 Process response to methotrexate
GO:0006979 Process response to oxidative stress
GO:0048545 Process response to steroid hormone stimulus
GO:0006810 Process transport

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_012833  UCSC Browser NP_036965
2 XM_577883  UCSC Browser XP_577883

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

D86086   L49379   NM_012833   X96393   XM_577883  

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Grisk O, et al. (2009) "Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function." Pharmacogenet Genomics. 19(4):276-288. PMID:19214140
  2. [ + ] Ban D, et al. (2009) "Decreased Mrp2-dependent bile flow in the post-warm ischemic rat liver." J Surg Res. 153(2):310-316. PMID:18662814
  3. [ + ] Zalups RK, et al. (2009) "MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA." Toxicol Appl Pharmacol. 235(1):10-17. PMID:19063911
  4. [ + ] Qadri I, et al. (2009) "Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2)." Toxicol Appl Pharmacol. 234(3):281-292. PMID:19010343
  5. [ + ] Minami S, et al. (2009) "Posttranslational regulation of Abcc2 expression by SUMOylation system." Am J Physiol Gastrointest Liver Physiol. 296(2):G406-G413. PMID:19074644
  6. [ + ] Itagaki S, et al. (2008) "Contribution of multidrug resistance-associated protein 2 to secretory intestinal transport of organic anions." Biol Pharm Bull. 31(1):146-148. PMID:18175959
  7. [ + ] Rost D, et al. (2008) "Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis." Eur J Med Res. 13(7):314-318. PMID:18700187
  8. [ + ] Abe F, et al. (2008) "Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats." Life Sci. 83(7-8):229-235. PMID:18638490
  9. [ + ] Ogura J, et al. (2008) "Alteration of Mrp2 and P-gp expression, including expression in remote organs, after intestinal ischemia-reperfusion." Life Sci. 82(25-26):1242-1248. PMID:18538350
  10. [ + ] MacLean C, et al. (2008) "Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats." Drug Metab Dispos. 36(7):1249-1254. PMID:18378562
  11. [ + ] Tanaka Y, et al. (2008) "Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2)." Toxicol Sci. 101(1):171-178. PMID:17959626
  12. [ + ] Micuda S, et al. (2008) "Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone." J Gastroenterol Hepatol. 23(7 Pt 2):e225-e230. PMID:17683490
  13. [ + ] Zinchuk V, et al. (2007) "Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat." Histochem Cell Biol. 127(5):503-512. PMID:17384956
  14. [ + ] Leslie EM, et al. (2007) "Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats." Carcinogenesis. 28(12):2650-2656. PMID:17724374
  15. [ + ] Planchamp C, et al. (2007) "Function of both sinusoidal and canalicular transporters controls the concentration of organic anions within hepatocytes." Mol Pharmacol. 71(4):1089-1097. PMID:17234897
  16. [ + ] Fouassier L, et al. (2007) "Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes." Am J Physiol Gastrointest Liver Physiol. 293(1):G25-G35. PMID:17615179
  17. [ + ] Li GX, et al. (2007) "Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats." Exp Toxicol Pathol. 58(6):447-453. PMID:17467962
  18. [ + ] Mottino AD, et al. (2007) "Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis." Am J Physiol Gastrointest Liver Physiol. 293(1):G391-G402. PMID:17463180
  19. [ + ] Okada K, et al. (2007) "Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers." Am J Physiol Gastrointest Liver Physiol. 292(5):G1450-G1463. PMID:17038627
  20. [ + ] Chiba M, et al. (2007) "Down-regulation of intestinal multidrug resistance-associated protein 2 in long-evans cinnamon rats." Drug Metab Pharmacokinet. 22(6):450-455. PMID:18159133
  21. [ + ] Notenboom S, et al. (2006) "Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure." J Pharmacol Exp Ther. 318(3):1194-1202. PMID:16757538
  22. [ + ] Suzuki T, et al. (2006) "Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats." Life Sci. 79(5):455-461. PMID:16483613
  23. [ + ] Simon FR, et al. (2006) "Hormonal regulation of hepatic multidrug resistance-associated protein 2 (Abcc2) primarily involves the pattern of growth hormone secretion." Am J Physiol Gastrointest Liver Physiol. 290(4):G595-G608. PMID:16537972
  24. [ + ] Bolder U, et al. (2006) "Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms." Cell Stress Chaperones. 11(1):89-100. PMID:16572733
  25. [ + ] de Waart DR, et al. (2006) "Multidrug resistance associated protein 2 mediates transport of prostaglandin E2." Liver Int. 26(3):362-368. PMID:16584400
  26. [ + ] Gao Y, et al. (2006) "[Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats]" Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 24(5):278-280. PMID:16737587
  27. [ + ] Sekine S, et al. (2006) "Oxidative stress and Mrp2 internalization." Free Radic Biol Med. 40(12):2166-2174. PMID:16785030
  28. [ + ] Zamek-Gliszczynski MJ, et al. (2006) "Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat." J Pharmacol Exp Ther. 319(1):459-467. PMID:16857726
  29. [ + ] Shibayama Y, et al. (2006) "Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats." Cancer Sci. 97(11):1260-1266. PMID:16925582
  30. [ + ] Nishimura M, et al. (2006) "Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes." Drug Metab Pharmacokinet. 21(4):297-307. PMID:16946557
  31. [ + ] Geier A, et al. (2005) "Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat." J Hepatol. 43(6):1021-1030. PMID:16139386
  32. [ + ] Mottino AD, et al. (2005) "Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity." Am J Physiol Gastrointest Liver Physiol. 288(2):G327-G336. PMID:15374814
  33. [ + ] Jones BR, et al. (2005) "The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)." Mol Pharmacol. 68(3):701-710. PMID:15917434
  34. [ + ] Hesselink DA, et al. (2005) "Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2." Am J Transplant. 5(5):987-994. PMID:15816878
  35. [ + ] Dietrich CG, et al. (2004) "Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2." Gastroenterology. 126(4):1044-1053. PMID:15057744
  36. [ + ] Smeets PH, et al. (2004) "Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter." J Am Soc Nephrol. 15(11):2828-2835. PMID:15504935
  37. [ + ] Kudo A, et al. (2004) "Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver." Hepatology. 39(4):1099-1109. PMID:15057914
  38. [ + ] Chang TH, et al. (2004) "Expression of MRP2 and MRP3 during liver regeneration after 90% partial hepatectomy in rats." Transplantation. 77(1):22-27. PMID:14724430
  39. [ + ] Reichard JF, et al. (2003) "Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal." Arch Biochem Biophys. 411(2):243-250. PMID:12623073
  40. [ + ] Potschka H, et al. (2003) "Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats." Epilepsia. 44(12):1479-1486. PMID:14636316
  41. [ + ] Norimizu S, et al. (2003) "Carbon monoxide stimulates mrp2-dependent excretion of bilirubin-IXalpha into bile in the perfused rat liver." Antioxid Redox Signal. 5(4):449-456. PMID:13678533
  42. [ + ] Geier A, et al. (2003) "Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis." Hepatology. 38(2):345-354. PMID:12883478
  43. [ + ] Potschka H, et al. (2003) "Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity." J Pharmacol Exp Ther. 306(1):124-131. PMID:12663688
  44. [ + ] Tomer G, et al. (2003) "Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2." Pediatr Res. 53(2):288-294. PMID:12538788
  45. [ + ] Tygstrup N, et al. (2002) "Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models." Biochem Biophys Res Commun. 290(1):518-525. PMID:11779202
  46. [ + ] Li X, et al. (2002) "Mrp2 modulates the activity of chloride channels in isolated hepatocytes." Hepatology. 36(1):65-71. PMID:12085350
  47. [ + ] Tanaka Y, et al. (2002) "Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice." Am J Physiol Gastrointest Liver Physiol. 282(4):G656-G662. PMID:11897625
  48. [ + ] Ito K, et al. (2001) "Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate." Am J Physiol Gastrointest Liver Physiol. 281(4):G1034-G1043. PMID:11557524
  49. [ + ] Buchler M, et al. (1996) "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats." J Biol Chem. 271(25):15091-15098. PMID:8662992
  50. [ + ] Paulusma CC, et al. (1996) "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene." Science. 271(5252):1126-1128. PMID:8599091