FUT4 | GeneID:2526 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2526 Official Symbol FUT4
Locus N/A Gene Type protein-coding
Synonyms CD15; ELFT; FCT3A; FUC-TIV; FUTIV
Full Name fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Description fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Chromosome 11q21
Also Known As ELAM ligand fucosyltransferase; fucosyltransferase 4; fucosyltransferase IV; galactoside 3-L-fucosyltransferase
Summary The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 1538

ID Symbol Protein Species
GeneID:2526 FUT4 NP_002024.1 Homo sapiens
GeneID:14345 Fut4 NP_034372.1 Mus musculus
GeneID:60670 Fut4 NP_071555.2 Rattus norvegicus
GeneID:428092 FUT4 NP_001026658.1 Gallus gallus
GeneID:449507 FUT4 NP_001008985.1 Pan troglodytes

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab15614 CD15 antibody [VIM-C6] (ab15614); Mouse monoclonal [VIM-C6] to CD15
2 abcam ab64603 CD15 antibody [MEM-158] (Phycoerythrin) (ab64603); Mouse monoclonal [MEM-158] to CD15 (Phycoerythrin)
3 abcam ab62588 CD15 antibody [1.BB.220] (Phycoerythrin) (ab62588); Mouse monoclonal [1.BB.220] to CD15 (Phycoerythrin)
4 abcam ab53997 CD15 antibody [LeuM1] (ab53997); Mouse monoclonal [LeuM1] to CD15
5 abcam ab53999 CD15 antibody [LeuM1], prediluted (ab53999); Mouse monoclonal [LeuM1] to CD15, prediluted
6 abcam ab51369 CD15 antibody [CLB-gran/2, B4] (ab51369); Mouse monoclonal [CLB-gran/2, B4] to CD15
7 abcam ab49758 CD15 antibody [BY87] (ab49758); Mouse monoclonal [BY87] to CD15
8 abcam ab20137 CD15 antibody [28] (ab20137); Mouse monoclonal [28] to CD15
9 abcam ab13453 CD15 antibody [DU-HL60-3] (ab13453); Mouse monoclonal [DU-HL60-3] to CD15
10 abcam ab665 CD15 antibody [MEM-158] (ab665); Mouse monoclonal [MEM-158] to CD15
11 abcam ab28103 CD15 antibody [MEM-158] (Biotin) (ab28103); Mouse monoclonal [MEM-158] to CD15 - Affinity Matrix (Biotin)
12 abcam ab18272 CD15 antibody [MEM-158] (FITC) (ab18272); Mouse monoclonal [MEM-158] to CD15 (FITC)
13 abcam ab17080 CD15 antibody [MMA] (ab17080); Mouse monoclonal [MMA] to CD15
14 abcam ab7495 CD15 antibody [MMA], prediluted (ab7495); Mouse monoclonal [MMA] to CD15, prediluted
15 abcam ab754 CD15 antibody [MY-1] (ab754); Mouse monoclonal [MY-1] to CD15
16 abcam ab17136 CD15 antibody [My-1], prediluted (ab17136); Mouse monoclonal [My-1] to CD15, prediluted
17 abcam ab74035 CD15 antibody [P12] (ab74035); Mouse monoclonal [P12] to CD15
18 abcam ab25725 CD15 antibody [TG1] (Biotin) (ab25725); Mouse monoclonal [TG1] to CD15 (Biotin)
19 abgent AP2773c FUT4 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab)
20 scbt FUT4 FUT4 Antibody / FUT4 Antibodies;
21 sigma C7798 Monoclonal Anti-CD15 antibody produced in mouse ;

Exon, Intron and UTRs

Exon, Intron and UTRs of FUT4 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of FUT4 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0009986 Component cell surface
GO:0005794 Component Golgi apparatus
GO:0032580 Component Golgi cisterna membrane
GO:0016021 Component integral to membrane
GO:0016020 Component membrane
GO:0005624 Component membrane fraction
GO:0046920 Function alpha(1,3)-fucosyltransferase activity
GO:0016757 Function transferase activity, transferring glycosyl groups
GO:0005975 Process carbohydrate metabolic process
GO:0042355 Process L-fucose catabolic process
GO:0006486 Process protein amino acid glycosylation

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_002033  UCSC Browser NP_002024

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
Calcitriol
  • Calcitriol results in decreased expression of FUT4 mRNA
16002434
Doxorubicin
  • Doxorubicin results in decreased expression of FUT4 protein
17852453

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Adenocarcinoma inferred via Doxorubicin 17418594
Bone Marrow Neoplasms inferred via Doxorubicin 14601052
Brain Neoplasms inferred via Doxorubicin 17150277
Breast Neoplasms inferred via Doxorubicin 15692762, 17426702, 16826403, 18382427, 17369602, 16264153, 15136595, 11325840, 16322301, 16096432, 15993339, 15634643, 15567936, 15994142, 15668708, 18234424, 16935488, 18628466, 17983394, 15939500
Carcinoid Tumor inferred via Doxorubicin 16051944
Carcinoma, Hepatocellular inferred via Doxorubicin 18059187, 16023760, 16234567, 17876044
Carcinoma, Renal Cell inferred via Doxorubicin 16201981
Cardiomyopathies inferred via Doxorubicin 16952015, 15811867, 17007740, 17382496, 16731534, 16109756, 16242529, 16364871, 16651473, 17351982, 17131338, 16455267, 18627295, 17329180, 15505089, 16278810, 15476868, 16269455, 17974986, 17308081
Cardiomyopathy, Dilated inferred via Doxorubicin 17334414, 16243910
Colorectal Neoplasms inferred via Doxorubicin 18259882
Drug Toxicity inferred via Doxorubicin 18602426
Endometrial Neoplasms inferred via Doxorubicin 17359293
Endomyocardial Fibrosis inferred via Doxorubicin 18037988
Glioblastoma inferred via Doxorubicin 17150277
Head and Neck Neoplasms inferred via Doxorubicin 15692506
Heart Diseases inferred via Doxorubicin 16707910, 16144979, 16330681, 16879835, 16244372, 16244371
Hemangiosarcoma inferred via Doxorubicin 15692506
Hepatitis, Toxic inferred via Doxorubicin 17416283
Hodgkin Disease inferred via Doxorubicin 17606976, 18501091, 15147373
Kidney Diseases inferred via Doxorubicin 16775033, 15369732
Kidney Failure inferred via Doxorubicin 17922066
Kidney Failure, Chronic inferred via Doxorubicin 16707910
Leukemia, Erythroblastic, Acute inferred via Doxorubicin 16085563
Liver Cirrhosis, Experimental inferred via Doxorubicin 16595196, 16439617
Liver Neoplasms, Experimental inferred via Doxorubicin 17085340, 16842330
Lung Neoplasms inferred via Doxorubicin 17418594
Lymphoma inferred via Doxorubicin 16098063
Lymphoma, Non-Hodgkin inferred via Doxorubicin 17654614
Lymphoma, T-Cell inferred via Doxorubicin 15621674
Mammary Neoplasms, Experimental inferred via Doxorubicin 15458769
Melanoma inferred via Doxorubicin 16827129
Mucositis inferred via Doxorubicin 17415656
Neoplasm Metastasis inferred via Doxorubicin 18259882
Nephrotic Syndrome inferred via Doxorubicin 15640375, 16889571
Neuroblastoma inferred via Doxorubicin 15555623
Osteosarcoma inferred via Doxorubicin 15930896
Phyllodes Tumor inferred via Doxorubicin 17983394
Prostatic Neoplasms inferred via Doxorubicin 15897917, 16729912, 16868541, 15749863, 18437689, 16888761
Sarcoma inferred via Doxorubicin 18313854, 16767912, 15625365, 15675481, 17203757, 17710206
Sarcoma, Ewing's inferred via Doxorubicin 14601052, 16326096
Sarcoma, Kaposi inferred via Doxorubicin 17846226
Skin Neoplasms inferred via Doxorubicin 15692506
Soft Tissue Neoplasms inferred via Doxorubicin 16767912, 17203757, 15625365
Thyroid Neoplasms inferred via Doxorubicin 17909728, 16010429
Urinary Bladder Neoplasms inferred via Doxorubicin 17653716
Ventricular Dysfunction, Left inferred via Doxorubicin 17334414, 16364871
Breast Neoplasms inferred via Calcitriol 11237771
Carcinoma, Squamous Cell inferred via Calcitriol 11237771
Encephalomyelitis, Autoimmune, Experimental inferred via Calcitriol 15138306
Prostatic Hyperplasia inferred via Calcitriol 15572423
Prostatic Neoplasms inferred via Calcitriol 12479363, 16289102, 16644109

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Read TA, et al. (2009) "Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma." Cancer Cell. 15(2):135-147. PMID:19185848
  2. [ + ] Plesa C, et al. (2008) "Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia: a single-institution experience." Cancer. 112(3):572-580. PMID:18085638
  3. [ + ] Zhang Z, et al. (2008) "Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth." Biochim Biophys Acta. 1783(2):287-296. PMID:18023290
  4. [ + ] Azuma Y, et al. (2007) "Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis." Biol Pharm Bull. 30(4):655-660. PMID:17409497
  5. [ + ] Cruse JM, et al. (2007) "Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML." Exp Mol Pathol. 83(2):274-276. PMID:17662271
  6. [ + ] Yang X, et al. (2007) "Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation." Int J Biochem Cell Biol. 39(9):1722-1730. PMID:17556010
  7. [ + ] Higai K, et al. (2006) "Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein." Biochim Biophys Acta. 1760(9):1355-1363. PMID:16842926
  8. [ + ] Martinez M, et al. (2005) "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII." J Biol Chem. 280(7):5378-5390. PMID:15579466
  9. [ + ] Azuma Y, et al. (2004) "Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis." Biochim Biophys Acta. 1672(3):157-163. PMID:15182935
  10. [ + ] Barry SM, et al. (2003) "Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells." Blood. 102(5):1771-1778. PMID:12738675
  11. [ + ] Roos C, et al. (2002) "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism." J Biol Chem. 277(5):3168-3175. PMID:11698403
  12. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  13. [ + ] Withers DA, et al. (2000) "Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line." J Biol Chem. 275(51):40588-40593. PMID:11006292
  14. [ + ] Kudo T, et al. (1998) "Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney." J Biol Chem. 273(41):26729-26738. PMID:9756916
  15. [ + ] Ootaka T, et al. (1997) "Glomerulointerstitial interaction of adhesion molecules in IgA nephropathy and membranoproliferative glomerulonephritis." Am J Kidney Dis. 29(6):843-850. PMID:9186069
  16. [ + ] Bonaldo MF, et al. (1996) "Normalization and subtraction: two approaches to facilitate gene discovery." Genome Res. 6(9):791-806. PMID:8889548
  17. [ + ] McCurley RS, et al. (1995) "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21." Genomics. 26(1):142-146. PMID:7782074
  18. [ + ] Taatjes DJ, et al. (1994) "Localization of anti-Leu-M1 (CD15) binding sites in Hodgkin's disease by immunoelectron microscopic examination." Am J Clin Pathol. 101(2):140-148. PMID:8116567
  19. [ + ] Reguigne I, et al. (1994) "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21." Cytogenet Cell Genet. 66(2):104-106. PMID:8287679
  20. [ + ] Bajorath J, et al. (1994) "CD62/P-selectin binding sites for myeloid cells and sulfatides are overlapping." Biochemistry. 33(6):1332-1339. PMID:7508745
  21. [ + ] Lowe JB, et al. (1991) "Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion." J Biol Chem. 266(26):17467-17477. PMID:1716630
  22. [ + ] Kumar R, et al. (1991) "Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants." J Biol Chem. 266(32):21777-21783. PMID:1718983
  23. [ + ] Goelz SE, et al. (1990) "ELFT: a gene that directs the expression of an ELAM-1 ligand." Cell. 63(6):1349-1356. PMID:1702034
  24. [ + ] Skubitz KM, et al. (1987) "Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils." J Immunol. 139(5):1631-1639. PMID:3305706