Abcc1 | GeneID:24565 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 24565 Official Symbol Abcc1
Locus N/A Gene Type protein-coding
Synonyms Abcc1a; Avcc1a; Mrp; Mrp1
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Chromosome 10q11
Also Known As ATP-binding cassette sub-family C ( CFTR/MRP) member 1a; multidrug resistance protein 1; multiple drug resistance-associated protein
Summary ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 55459

ID Symbol Protein Species
GeneID:4363 ABCC1 NP_004987.2 Homo sapiens
GeneID:17250 Abcc1 NP_032602.1 Mus musculus
GeneID:24565 Abcc1 NP_071617.2 Rattus norvegicus
GeneID:34686 MRP NP_995695.1 Drosophila melanogaster
GeneID:180408 mrp-2 NP_508121.1 Caenorhabditis elegans
GeneID:180409 mrp-1 NP_001033553.1 Caenorhabditis elegans
GeneID:281588 ABCC1 NP_776648.1 Bos taurus
GeneID:395416 ABCC1 NP_001012540.1 Gallus gallus
GeneID:403453 ABCC1 NP_001002971.1 Canis lupus familiaris
GeneID:453952 ABCC1 XP_001145351.1 Pan troglodytes
GeneID:839277 ATMRP5 NP_171908.1 Arabidopsis thaliana
GeneID:851713 YCF1 NP_010419.1 Saccharomyces cerevisiae
GeneID:1279254 AgaP_AGAP009835 XP_553715.1 Anopheles gambiae
GeneID:2540937 abc3 NP_595055.1 Schizosaccharomyces pombe
GeneID:2543193 abc2 NP_593943.1 Schizosaccharomyces pombe
GeneID:2679616 MGG_01674 XP_363748.2 Magnaporthe grisea
GeneID:2713263 NCU09012.1 XP_331404.1 Neurospora crassa
GeneID:2895493 KLLA0F20075g XP_455982.1 Kluyveromyces lactis
GeneID:4331585 Os03g0142800 NP_001048934.1 Oryza sativa
GeneID:4623012 AGOS_AGR047W NP_986712.1 Eremothecium gossypii
GeneID:100002010 LOC100002010 XP_001341895.2 Danio rerio

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016323 Component basolateral plasma membrane
GO:0005737 Component cytoplasm
GO:0016021 Component integral to membrane
GO:0005887 Component integral to plasma membrane
GO:0016020 Component membrane
GO:0005886 Component plasma membrane
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0015562 Function efflux transmembrane transporter activity
GO:0034634 Function glutathione transmembrane transporter activity
GO:0034040 Function lipid-transporting ATPase activity
GO:0005324 Function long-chain fatty acid transporter activity
GO:0015559 Function multidrug efflux pump activity
GO:0000166 Function nucleotide binding
GO:0016491 Function oxidoreductase activity
GO:0046624 Function sphingolipid transporter activity
GO:0005215 Function transporter activity
GO:0008559 Function xenobiotic-transporting ATPase activity
GO:0060326 Process cell chemotaxis
GO:0043215 Process daunorubicin transport
GO:0046618 Process drug export
GO:0034775 Process glutathione transmembrane transport
GO:0006855 Process multidrug transport
GO:0043526 Process neuroprotection
GO:0055114 Process oxidation reduction
GO:0033700 Process phospholipid efflux
GO:0015911 Process plasma membrane long-chain fatty acid transport
GO:0030335 Process positive regulation of cell migration
GO:0042493 Process response to drug
GO:0006979 Process response to oxidative stress
GO:0055085 Process transmembrane transport
GO:0006810 Process transport
GO:0042908 Process xenobiotic transport

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_022281  UCSC Browser NP_071617
2 XM_001053148  UCSC Browser XP_001053148

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Gazzin S, et al. (2008) "Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces." J Comp Neurol. 510(5):497-507. PMID:18680196
  2. [ + ] Dorajoo R, et al. (2008) "Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy." Life Sci. 82(15-16):823-830. PMID:18509883
  3. [ + ] Ronaldson PT, et al. (2008) "HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells." J Neurochem. 106(3):1298-1313. PMID:18485102
  4. [ + ] Thews O, et al. (2008) "Activity of drug efflux transporters in tumor cells under hypoxic conditions." Adv Exp Med Biol. 614():157-164. PMID:18290326
  5. [ + ] Valente RC, et al. (2008) "ABCB1 (P-glycoprotein) but not ABCC1 (MRP1) is downregulated in peripheral blood mononuclear cells of spontaneously hypertensive rats." Pflugers Arch. 456(2):359-368. PMID:18057958
  6. [ + ] Patel LN, et al. (2008) "Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells." J Pharm Sci. 97(6):2340-2349. PMID:17854063
  7. [ + ] Krause MS, et al. (2007) "MRP1/GS-X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells?" Cell Biochem Funct. 25(1):23-32. PMID:16868918
  8. [ + ] Falcao AS, et al. (2007) "Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin." Neuroscience. 144(3):878-888. PMID:17141959
  9. [ + ] Kolberg A, et al. (2006) "Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency." Cell Biochem Funct. 24(1):23-39. PMID:16170839
  10. [ + ] Mitra P, et al. (2006) "Role of ABCC1 in export of sphingosine-1-phosphate from mast cells." Proc Natl Acad Sci U S A. 103(44):16394-16399. PMID:17050692
  11. [ + ] Nishimura M, et al. (2006) "Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes." Drug Metab Pharmacokinet. 21(4):297-307. PMID:16946557
  12. [ + ] Mercier C, et al. (2004) "Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes." Brain Res. 1021(1):32-40. PMID:15328029
  13. [ + ] Yang Z, et al. (2004) "Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1)." AAPS PharmSci. 6(1):E8. PMID:15198509
  14. [ + ] Dallas S, et al. (2003) "Functional expression of the multidrug resistance protein 1 in microglia." J Pharmacol Exp Ther. 307(1):282-290. PMID:12893836
  15. [ + ] Takayanagi S, et al. (2003) "Molecular identification and characterization of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile." J Exp Ther Oncol. 3(3):136-146. PMID:14641820
  16. [ + ] Cekic D, et al. (2003) "Upregulation in the expression of multidrug resistance protein Mrp1 mRNA and protein by increased bilirubin production in rat." Biochem Biophys Res Commun. 311(4):891-896. PMID:14623264
  17. [ + ] Nunoya K, et al. (2003) "Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1)." Drug Metab Dispos. 31(8):1016-1026. PMID:12867490
  18. [ + ] Hirrlinger J, et al. (2002) "Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells." J Neurosci Res. 69(3):318-326. PMID:12125073
  19. [ + ] Yang Z, et al. (2002) "Cloning and characterization of the rat multidrug resistance-associated protein 1." AAPS PharmSci. 4(3):E15. PMID:12423064
  20. [ + ] Pei QL, et al. (2002) "Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats." Hepatol Res. 22(1):58-64. PMID:11804835
  21. [ + ] Hirrlinger J, et al. (2001) "The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress." J Neurochem. 76(2):627-636. PMID:11208926
  22. [ + ] Fernetti C, et al. (2001) "Preparation of an antibody recognizing both human and rodent MRP1." Biochem Biophys Res Commun. 288(4):1064-1068. PMID:11689020
  23. [ + ] Buchler M, et al. (1996) "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats." J Biol Chem. 271(25):15091-15098. PMID:8662992