A2M | GeneID:2 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 2 Official Symbol A2M
Locus N/A Gene Type protein-coding
Synonyms CPAMD5; DKFZp779B086; FWP007; S863-7
Full Name alpha-2-macroglobulin
Description alpha-2-macroglobulin
Chromosome 12p13.3-p12.3
Also Known As
Summary Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 37248

ID Symbol Protein Species
GeneID:2 A2M NP_000005.2 Homo sapiens
GeneID:24153 A2m NP_036620.1 Rattus norvegicus
GeneID:232345 A2m NP_783327.1 Mus musculus
GeneID:418251 A2M XP_416476.2 Gallus gallus
GeneID:465372 A2M XP_001139819.1 Pan troglodytes
GeneID:477699 A2M XP_534893.2 Canis lupus familiaris
GeneID:513856 A2M XP_591612.3 Bos taurus
GeneID:562067 LOC562067 XP_001922903.1 Danio rerio
GeneID:569025 LOC569025 XP_697477.3 Danio rerio
GeneID:793035 zgc:171445 NP_001107101.1 Danio rerio
GeneID:793100 LOC793100 XP_001332356.1 Danio rerio
GeneID:100003785 LOC100003785 XP_001921519.1 Danio rerio
GeneID:100006782 LOC100006782 XP_001345438.2 Danio rerio
GeneID:100006895 LOC100006895 XP_001923676.1 Danio rerio
GeneID:100006925 LOC100006925 XP_001921577.1 Danio rerio
GeneID:100006947 sb:cb37 XP_001345541.2 Danio rerio
GeneID:100006972 LOC100006972 XP_001345556.2 Danio rerio
GeneID:100006993 wu:fb68b01 XP_001345569.2 Danio rerio
GeneID:100101650 zgc:165518 NP_001093623.1 Danio rerio
GeneID:100136837 zgc:171446 NP_001108028.1 Danio rerio
GeneID:100137103 zgc:171426 NP_001108172.1 Danio rerio
GeneID:100137119 si:dkey-46g23.3 NP_001108188.1 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab7339 alpha 2 Macroglobulin antibody (HRP) (ab7339); Goat polyclonal to alpha 2 Macroglobulin (HRP)
2 abcam ab5722 alpha 2 Macroglobulin antibody (ab5722); Chicken polyclonal to alpha 2 Macroglobulin
3 abcam ab7337 alpha 2 Macroglobulin antibody (ab7337); Goat polyclonal to alpha 2 Macroglobulin
4 abcam ab8770 alpha 2 Macroglobulin antibody (ab8770); Sheep polyclonal to alpha 2 Macroglobulin
5 abcam ab7338 alpha 2 Macroglobulin antibody (Biotin) (ab7338); Goat polyclonal to alpha 2 Macroglobulin (Biotin)
6 abcam ab58799 alpha 2 Macroglobulin antibody (ab58799); Sheep polyclonal to alpha 2 Macroglobulin
7 abcam ab58703 alpha 2 Macroglobulin antibody (ab58703); Rabbit polyclonal to alpha 2 Macroglobulin
8 abcam ab56005 alpha 2 Macroglobulin antibody (ab56005); Rabbit polyclonal to alpha 2 Macroglobulin
9 abcam ab48555 alpha 2 Macroglobulin antibody (ab48555); Rabbit polyclonal to alpha 2 Macroglobulin
10 abcam ab36995 alpha 2 Macroglobulin antibody [2D9] (ab36995); Mouse monoclonal [2D9] to alpha 2 Macroglobulin
11 abcam ab36265 alpha 2 Macroglobulin antibody (HRP) (ab36265); Sheep polyclonal to alpha 2 Macroglobulin (HRP)
12 abcam ab36260 alpha 2 Macroglobulin antibody (Alkaline Phosphatase) (ab36260); Sheep polyclonal to alpha 2 Macroglobulin (Alkaline Phosphatase)
13 abcam ab20508 alpha 2 Macroglobulin antibody [1201] (ab20508); Mouse monoclonal [1201] to alpha 2 Macroglobulin
14 abcam ab20063 alpha 2 Macroglobulin antibody [1204] (ab20063); Mouse monoclonal [1204] to alpha 2 Macroglobulin
15 abcam ab16421 alpha 2 Macroglobulin antibody (ab16421); Chicken polyclonal to alpha 2 Macroglobulin
16 abnova MAB0758 A2M monoclonal antibody, clone 9A3; Mouse monoclonal antibody raised against a native A2M.
17 abnova MAB0759 A2M monoclonal antibody, clone 3D1; Mouse monoclonal antibody raised against a native A2M.
18 abnova H00000002-M03 A2M monoclonal antibody (M03), clone 2B5; Mouse monoclonal antibody raised against a partial recombinant A2M.
19 abnova MAB0757 A2M monoclonal antibody, clone 2D9; Mouse monoclonal antibody raised against a native A2M.
20 acris BP611AP Alpha-2-macroglobulin; antibody Ab
21 acris BM2557 Alpha-2-macroglobulin; antibody Ab
22 acris R1595P Alpha-2-macroglobulin; antibody Ab
23 acris AP01089PU-N Alpha-2-macroglobulin; antibody Ab
24 acris DP049 Alpha-2-macroglobulin; antibody Ab
25 acris DP049-05 Alpha-2-macroglobulin; antibody Ab
26 acris R1595 Alpha-2-macroglobulin; antibody Ab
27 acris BP611 Alpha-2-macroglobulin; antibody Ab
28 acris R1595B Alpha-2-macroglobulin; antibody Ab
29 acris BP611HRP Alpha-2-macroglobulin; antibody Ab
30 acris BM2148 Alpha-2-macroglobulin; antibody Ab
31 acris BP2280 Alpha-2-macroglobulin; antibody Ab
32 acris R1595HRP Alpha-2-macroglobulin; antibody Ab
33 acris AP07617PU-N Alpha-2-macroglobulin; antibody Ab
34 acris AP05465SU-N Alpha-2-macroglobulin; antibody Ab
35 acris BM585 Alpha-2-macroglobulin; antibody Ab
36 scbt A2M A2M Antibody / A2M Antibodies;
37 sigma HPA002265 Anti-A2M antibody produced in rabbit ;
38 sigma M5649 Anti-α2-Macroglobulin antibody produced in goat ;

Exon, Intron and UTRs

Exon, Intron and UTRs of A2M Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of A2M Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005576 Component extracellular region
GO:0005615 Component extracellular space
GO:0005634 Component nucleus
GO:0031093 Component platelet alpha granule lumen
GO:0019899 Function enzyme binding
GO:0019966 Function interleukin-1 binding
GO:0019959 Function interleukin-8 binding
GO:0004867 Function serine-type endopeptidase inhibitor activity
GO:0043120 Function tumor necrosis factor binding
GO:0001869 Process negative regulation of complement activation, lectin pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_000014  UCSC Browser NP_000005

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
1-Naphthylisothiocyanate
  • 1-Naphthylisothiocyanate results in increased expression of A2M mRNA
12883083
3,4-dichloroaniline
  • 3,4-dichloroaniline results in decreased expression of A2M mRNA
17292976
Acetaminophen
  • Acetaminophen results in increased expression of A2M mRNA
12883083
Antimony
  • Antimony results in decreased expression of A2M mRNA
17547211
Antimony Potassium Tartrate
  • Antimony Potassium Tartrate results in decreased expression of A2M mRNA
17547211
beta-Naphthoflavone
  • beta-Naphthoflavone results in decreased expression of A2M mRNA
12883083
Cisplatin
  • Cisplatin binds to A2M protein
16773208
Clofibrate
  • Clofibrate results in increased expression of A2M mRNA
12883083
Clofibric Acid
  • Clofibric Acid affects the expression of A2M mRNA
17602206
Corticosterone
  • Corticosterone results in increased expression of A2M mRNA
15755911
Dexamethasone
  • Dexamethasone results in decreased expression of A2M mRNA
12971794
Dimethylnitrosamine
  • Dimethylnitrosamine results in decreased expression of A2M mRNA
17547211
Dimethyl Sulfoxide
  • Dimethyl Sulfoxide results in increased expression of A2M mRNA
12883083
Ethinyl Estradiol
  • Ethinyl Estradiol results in decreased expression of A2M mRNA
17557909
ethinyl estradiol-desogestrel combination
  • ethinyl estradiol-desogestrel combination results in increased expression of A2M protein
10928463
furan
  • furan results in decreased expression of A2M mRNA
15120968
imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)
  • imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) binds to A2M protein
16773208
Isoniazid
  • Isoniazid results in increased expression of A2M mRNA
12883083
Lipopolysaccharides
  • Lipopolysaccharides results in increased expression of A2M mRNA
11779202
Mercury
  • Mercury results in decreased expression of A2M mRNA
17547211
Methapyrilene
  • Methapyrilene results in decreased expression of A2M mRNA
15120968
naphthalene
  • naphthalene metabolite binds to A2M protein
15892573
nitrosobenzylmethylamine
  • nitrosobenzylmethylamine results in increased expression of A2M mRNA
17616710
pirinixic acid
  • pirinixic acid results in decreased expression of A2M mRNA
16940010
Progesterone
  • Progesterone affects the expression of A2M mRNA
17251523
sodium arsenite
  • sodium arsenite results in increased expression of A2M mRNA
16014739
Turpentine
  • Turpentine results in increased expression of A2M mRNA
11779202

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Alzheimer Disease marker
Blood Protein Disorders marker
Lung Diseases, Obstructive marker
Acute-Phase Reaction inferred via Turpentine 16044259
Adrenal Gland Neoplasms inferred via sodium arsenite 15276417
Adrenocortical Adenoma inferred via sodium arsenite 16712894
Carcinoma, Hepatocellular inferred via sodium arsenite 15276417, 16507464
Carcinoma, Squamous Cell inferred via sodium arsenite 18572023
Genital Neoplasms, Female inferred via sodium arsenite 16452187
Hodgkin Disease inferred via sodium arsenite 12676792
Liver Neoplasms inferred via sodium arsenite 15276417, 16712894
Lung Neoplasms inferred via sodium arsenite 15276417, 16712894, 17077188
Melanoma inferred via sodium arsenite 16487513
Neoplasms inferred via sodium arsenite 11559025
Neural Tube Defects inferred via sodium arsenite 12854658
Ovarian Neoplasms inferred via sodium arsenite 15276417
Prostatic Neoplasms inferred via sodium arsenite 16039940
Skin Neoplasms inferred via sodium arsenite 18572023
Spinal Dysraphism inferred via sodium arsenite 12854658
Urinary Bladder Neoplasms inferred via sodium arsenite 11723127, 16712894, 16452187
Uterine Cervical Neoplasms inferred via sodium arsenite 11813266
Vascular Diseases inferred via sodium arsenite 17056641
Brain Hemorrhage, Traumatic inferred via Progesterone 17868700
Brain Injuries inferred via Progesterone 15665606, 15380490, 15845082
Breast Neoplasms inferred via Progesterone 17614352, 16175315, 15562024
Diabetic Neuropathies inferred via Progesterone 17187935
Encephalomyelitis, Autoimmune, Experimental inferred via Progesterone 17692515
Endometriosis inferred via Progesterone 16134523
Mammary Neoplasms, Experimental inferred via Progesterone 17203775, 11408345
Ovarian Neoplasms inferred via Progesterone 17393432, 16525653
Salivary Gland Neoplasms inferred via Progesterone 18045962
Spinal Cord Injuries inferred via Progesterone 15862959, 16503802
Edema inferred via pirinixic acid 12083418
Liver Neoplasms inferred via pirinixic acid 15890375
Esophageal Neoplasms inferred via nitrosobenzylmethylamine 16805852, 15878914, 15547721, 15623463, 15150132, 15264214, 15547733, 16510608, 16704527
Stomach Neoplasms inferred via nitrosobenzylmethylamine 17575124, 12958204
Liver Neoplasms inferred via Methapyrilene 15890375
Autoimmune Diseases inferred via Mercury 16634805
Hemolytic-Uremic Syndrome inferred via Lipopolysaccharides 16366002
Inflammation inferred via Lipopolysaccharides 17255318, 17963957
Iron Metabolism Disorders inferred via Lipopolysaccharides 17255318
Respiratory Hypersensitivity inferred via Lipopolysaccharides 10835634
Hepatitis, Toxic inferred via Isoniazid 14986274, 16770646, 17950035
Mycobacterium Infections inferred via Isoniazid 18474467
Seizures inferred via Isoniazid 16107249
Tuberculosis inferred via Isoniazid 18397238, 17950035, 15673755, 16770646, 15236969, 17720495
Neoplasms inferred via imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) 16773208
Polycystic Ovary Syndrome inferred via ethinyl estradiol-desogestrel combination 17105841
Thrombophilia inferred via ethinyl estradiol-desogestrel combination 11994571
Venous Thrombosis inferred via ethinyl estradiol-desogestrel combination 15869587
Acne Vulgaris inferred via Ethinyl Estradiol 17505938
Adenocarcinoma inferred via Ethinyl Estradiol 14692618
Arteriosclerosis inferred via Ethinyl Estradiol 11256880
Arthritis, Experimental inferred via Ethinyl Estradiol 15885639
Cholestasis inferred via Ethinyl Estradiol 17110522, 16919318, 17681005, 16105132, 11677210, 15861022, 17333356
Encephalomyelitis, Autoimmune, Experimental inferred via Ethinyl Estradiol 12538720
Fatty Liver inferred via Ethinyl Estradiol 15345470
Hypospadias inferred via Ethinyl Estradiol 16569931, 16945680
Infertility, Female inferred via Ethinyl Estradiol 12013081
Infertility, Male inferred via Ethinyl Estradiol 17937319
Panic Disorder inferred via Ethinyl Estradiol 11578682
Pruritus inferred via Ethinyl Estradiol 16919318, 15861022
Spermatocele inferred via Ethinyl Estradiol 16709447
Thrombophilia inferred via Ethinyl Estradiol 11994571
Thrombosis inferred via Ethinyl Estradiol 15669648
Uterine Neoplasms inferred via Ethinyl Estradiol 14692618
Venous Thrombosis inferred via Ethinyl Estradiol 15869587
Adenocarcinoma inferred via Dimethylnitrosamine 16033868
Carcinoma, Squamous Cell inferred via Dimethylnitrosamine 16033868
Esophageal Neoplasms inferred via Dimethylnitrosamine 17016578
Liver Cirrhosis, Experimental inferred via Dimethylnitrosamine 17203207, 17465448, 16570917, 14659978, 17196135, 14643895, 18567088, 15798949, 15571005, 15161499, 12918455, 15298665, 16042886, 15479170, 17881167, 15492853, 18629640, 15864749, 15763062, 16544323, 15842777, 15793283, 18371158, 17724770, 15723089, 14726149, 16627068, 15942678, 15744066, 15591649, 18239293, 16270385, 12925901, 15366600, 17348192, 17201889, 18237412, 17719030, 15081153, 16169303, 18364076, 15369754, 15099470, 14709902, 15577212, 15504291, 17666798, 15138612, 16603200, 15339415, 17432682, 17198567, 15086199, 15733078, 16009107, 18637143, 18672772, 15067225, 17640959, 15383259, 14568256, 18095165, 17036385, 17534399, 18210741
Liver Failure, Acute inferred via Dimethylnitrosamine 17457977
Liver Neoplasms inferred via Dimethylnitrosamine 3113478, 15890375
Liver Neoplasms, Experimental inferred via Dimethylnitrosamine 15603536
Lung Neoplasms inferred via Dimethylnitrosamine 16061637
Stomach Neoplasms inferred via Dimethylnitrosamine 16033868
Colonic Neoplasms inferred via Dexamethasone 15824018
Liver Cirrhosis, Experimental inferred via Dexamethasone 16718785
Lung Neoplasms inferred via Dexamethasone 15824018, 11195469
Multiple Myeloma inferred via Dexamethasone 15867202, 15744524, 16118317
Respiratory Distress Syndrome, Adult inferred via Dexamethasone 11700416
Mammary Neoplasms, Experimental inferred via Corticosterone 12807724
Liver Neoplasms inferred via Clofibric Acid 17602206
Dyslipidemias inferred via Clofibrate 16707586
Niemann-Pick Disease, Type C inferred via Clofibrate 9802331
Adenocarcinoma inferred via Cisplatin 11798837
Bone Marrow Neoplasms inferred via Cisplatin 14601052
Breast Neoplasms inferred via Cisplatin 18382427
Colorectal Neoplasms inferred via Cisplatin 15273666
Hodgkin Disease inferred via Cisplatin 16170182, 16200630
Kidney Failure, Acute inferred via Cisplatin 12690470
Lung Neoplasms inferred via Cisplatin 11798837, 17225452
Melanoma inferred via Cisplatin 16809738, 12393984, 12374674, 12883367, 18332650, 17761969, 15577323, 18176117, 16248763, 17023156, 16432458, 18505091
Melanoma, Amelanotic inferred via Cisplatin 15990972
Neoplasms inferred via Cisplatin 16773208
Ovarian Neoplasms inferred via Cisplatin 17225452
Sarcoma, Ewing's inferred via Cisplatin 14601052
Testicular Neoplasms inferred via Cisplatin 17225452
Urinary Bladder Neoplasms inferred via Cisplatin 12973940, 17225452
Vaginal Neoplasms inferred via Cisplatin 15577323
Leishmaniasis inferred via Antimony 15220340
Trypanosomiasis inferred via Antimony 15220340
Hepatitis, Toxic inferred via Acetaminophen 2444490, 16081117, 17562736, 17522070, 14986274, 15968718, 16227642, 16177239
Hyperalgesia inferred via Acetaminophen 16870215
Liver Failure, Acute inferred via Acetaminophen 16871587, 17185352
Pain inferred via Acetaminophen 16870215
Cholestasis, Intrahepatic inferred via 1-Naphthylisothiocyanate 10220858
Hepatitis, Toxic inferred via 1-Naphthylisothiocyanate 17522070
Liver Diseases inferred via 1-Naphthylisothiocyanate 17184895

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ADAMTS1 A2M / ADAMTS1 Affinity Capture-Western Kuno K (1999)
AMBP AMBP / A2M Affinity Capture-Western Falkenberg C (1990)
AMBP AMBP / A2M Affinity Capture-Western Falkenberg C (1994)
APOE A2M / APOE Affinity Capture-Western Krimbou L (1998)
APOE A2M / APOE Reconstituted Complex Krimbou L (1998)
B2M B2M / A2M Reconstituted Complex Gouin-Charnet A (2000)
CPB2 CPB2 / A2M Reconstituted Complex Valnickova Z (1996)
HSPA5 HSPA5 / A2M Reconstituted Complex Misra UK (2002)
IL10 A2M / IL10 Reconstituted Complex Garber TR (2000)
IL4 A2M / IL4 Reconstituted Complex Garber TR (2000)
KLK13 KLK13 / A2M Reconstituted Complex Kapadia C (2004)
KLK3 KLK3 / A2M Affinity Capture-Western Christensson A (1990)
LCAT A2M / LCAT Affinity Capture-Western Krimbou L (2001)
LCAT A2M / LCAT Reconstituted Complex Krimbou L (2001)
LEP A2M / LEP Reconstituted Complex Birkenmeier G (1998)
LRP1 LRP1 / A2M Co-crystal Structure Dolmer K (2000)
MMP2 MMP2 / A2M Reconstituted Complex Arbelaez LF (1997)
NGFB A2M / NGFB Reconstituted Complex Gonias SL (2000)
PAEP A2M / PAEP Co-purification Riely GJ (2000)
PAEP A2M / PAEP Reconstituted Complex Riely GJ (2000)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Yerbury JJ, et al. (2009) "alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species." J Biol Chem. 284(7):4246-4254. PMID:19074141
  2. [ + ] Edwards TL, et al. (2009) "An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3." Am J Med Genet B Neuropsychiatr Genet. 150B(5):721-735. PMID:19105203
  3. [ + ] French K, et al. (2008) "Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity." Biochemistry. 47(4):1176-1185. PMID:18171086
  4. [ + ] Mantuano E, et al. (2008) "Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling." J Biol Chem. 283(29):19904-19911. PMID:18499670
  5. [ + ] Tanskanen M, et al. (2008) "Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study." Ann Med. 40(3):232-239. PMID:18382889
  6. [ + ] Wen Y, et al. (2008) "Is alpha2-macroglobulin important in female stress urinary incontinence?" Hum Reprod. 23(2):387-393. PMID:18077315
  7. [ + ] Zhou YT, et al. (2008) "Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population." Neurosci Lett. 444(1):109-111. PMID:18706476
  8. [ + ] Moriya M, et al. (2008) "Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism." Am J Physiol Cell Physiol. 295(3):C708-C721. PMID:18579803
  9. [ + ] Barbe L, et al. (2008) "Toward a confocal subcellular atlas of the human proteome." Mol Cell Proteomics. 7(3):499-508. PMID:18029348
  10. [ + ] Anderson RB, et al. (2008) "Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism." J Leukoc Biol. 83(2):381-392. PMID:17967834
  11. [ + ] Beheiri A, et al. (2007) "Role of elevated alpha2-macroglobulin revisited: results of a case-control study in children with symptomatic thromboembolism." J Thromb Haemost. 5(6):1179-1184. PMID:17403113
  12. [ + ] Doan N, et al. (2007) "Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3." Biochem J. 407(1):23-30. PMID:17608619
  13. [ + ] Adler V, et al. (2007) "Alpha2-macroglobulin is a potential facilitator of prion protein transformation." Amyloid. 14(1):1-10. PMID:17453620
  14. [ + ] Bonacci GR, et al. (2007) "Activated alpha(2)-macroglobulin induces cell proliferation and mitogen-activated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line." Arch Biochem Biophys. 460(1):100-106. PMID:17288987
  15. [ + ] Reynolds CA, et al. (2006) "Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes." Behav Genet. 36(2):185-194. PMID:16402284
  16. [ + ] Haines JL, et al. (2006) "Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6." Invest Ophthalmol Vis Sci. 47(1):329-335. PMID:16384981
  17. [ + ] Depboylu C, et al. (2006) "Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease." Neurosci Lett. 400(3):187-190. PMID:16650578
  18. [ + ] Arnold JN, et al. (2006) "Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?" J Biol Chem. 281(11):6955-6963. PMID:16407218
  19. [ + ] Rugsarash W, et al. (2006) "The genetic association between alpha-2-macroglobulin (A2M) gene deletion polymorphism and low serum A2M concentration in overweight/obese Thais." Nutr Neurosci. 9(1-2):93-98. PMID:16910174
  20. [ + ] Mariani E, et al. (2006) "Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease." J Neurol Sci. 247(2):187-191. PMID:16784755
  21. [ + ] Arandjelovic S, et al. (2006) "Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1." J Biol Chem. 281(25):17061-17068. PMID:16641085
  22. [ + ] Zhang Y, et al. (2006) "Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin." J Biol Chem. 281(51):39096-39104. PMID:17071617
  23. [ + ] Xiao Y, et al. (2006) "[Association of the polymorphism in alpha-2 macroglobulin gene with essential tremor and Parkinson's disease]" Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 23(1):84-85. PMID:16456795
  24. [ + ] Lo HW, et al. (2005) "Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway." Cancer Cell. 7(6):575-589. PMID:15950906
  25. [ + ] Liu T, et al. (2005) "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." J Proteome Res. 4(6):2070-2080. PMID:16335952
  26. [ + ] Lin VK, et al. (2005) "Alpha(2) macroglobulin, a PSA binding protein, is expressed in human prostate stroma." Prostate. 63(3):299-308. PMID:15611997
  27. [ + ] Bian L, et al. (2005) "Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese." Biol Psychiatry. 58(9):731-737. PMID:16040006
  28. [ + ] Arandjelovic S, et al. (2005) "Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1." Arch Biochem Biophys. 438(1):29-35. PMID:15910735
  29. [ + ] Bisaro de Lorenc L, et al. (2005) "Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis." Clin Chem Lab Med. 43(11):1183-1189. PMID:16232083
  30. [ + ] Sun Y, et al. (2005) "[No evidence for genetic association between alpha-2 macroglobulin I1000V polymorphism and sporadic Alzheimer's disease in two independent Chinese populations]" Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 22(2):174-179. PMID:15793779
  31. [ + ] Misra UK, et al. (2005) "Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK." J Biol Chem. 280(28):26278-26286. PMID:15908432
  32. [ + ] Tayade C, et al. (2005) "Functions of alpha 2 macroglobulins in pregnancy." Mol Cell Endocrinol. 245(1-2):60-66. PMID:16297527
  33. [ + ] Cai L, et al. (2005) "Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients." Neuroreport. 16(9):1023-1026. PMID:15931081
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