FUK | GeneID:197258 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 197258 Official Symbol FUK
Locus N/A Gene Type protein-coding
Synonyms 1110046B12Rik; FLJ39408
Full Name fucokinase
Description fucokinase
Chromosome 16q22.1
Also Known As L-fucose kinase; OTTHUMP00000082728
Summary The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 15452

ID Symbol Protein Species
GeneID:197258 FUK NP_659496.2 Homo sapiens
GeneID:234730 Fuk NP_758487.2 Mus musculus
GeneID:307848 Fuk XP_226508.4 Rattus norvegicus
GeneID:468015 FUK XP_001170471.1 Pan troglodytes
GeneID:489715 FUK XP_546835.2 Canis lupus familiaris
GeneID:519181 FUK XP_597394.2 Bos taurus
GeneID:770049 FUK XP_001233364.1 Gallus gallus
GeneID:839420 AT1G01220 NP_563620.1 Arabidopsis thaliana
GeneID:4331392 Os03g0115100 NP_001048749.1 Oryza sativa
GeneID:100005144 LOC100005144 XP_001344272.1 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab69555 FUK antibody (ab69555); Rabbit polyclonal to FUK
2 abgent AP8165a Fucokinase Antibody (N-term); Purified Rabbit Polyclonal Antibody (Pab)
3 abgent AP8165b Fucokinase Antibody (C-term); Purified Rabbit Polyclonal Antibody (Pab)
4 acris AP15172PU-N Fucokinase (N-term); antibody Ab
5 acris AP15173PU-N Fucokinase (C-term); antibody Ab

Exon, Intron and UTRs

Exon, Intron and UTRs of FUK Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of FUK Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0005524 Function ATP binding
GO:0050201 Function fucokinase activity
GO:0000166 Function nucleotide binding
GO:0016740 Function transferase activity
GO:0008152 Process metabolic process
GO:0016310 Process phosphorylation

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_145059  UCSC Browser NP_659496

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
hydrazine
  • hydrazine results in decreased expression of FUK mRNA
15282401
Tobacco Smoke Pollution
  • Tobacco Smoke Pollution results in decreased expression of FUK mRNA
18087596

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Adenocarcinoma, Bronchiolo-Alveolar inferred via Tobacco Smoke Pollution 15814487
Lung Neoplasms inferred via Tobacco Smoke Pollution 11091918
Mouth Neoplasms inferred via Tobacco Smoke Pollution 15006635

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Ota T, et al. (2004) "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat Genet. 36(1):40-45. PMID:14702039
  2. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  3. [ + ] Clark HF, et al. (2003) "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13(10):2265-2270. PMID:12975309
  4. [ + ] Hinderlich S, et al. (2002) "Identification of human L-fucose kinase amino acid sequence." Biochem Biophys Res Commun. 294(3):650-654. PMID:12056818
  5. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932