aak-2 | GeneID:181727 | Caenorhabditis elegans

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 181727 Official Symbol aak-2
Locus T01C8.1 Gene Type protein-coding
Synonyms
Full Name N/A
Description AMP-Activated Kinase
Chromosome N/A
Also Known As AMP-Activated Kinase family member (aak-2)
Summary N/A

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 4551

ID Symbol Protein Species
GeneID:5563 PRKAA2 NP_006243.2 Homo sapiens
GeneID:43904 SNF1A NP_477313.1 Drosophila melanogaster
GeneID:78975 Prkaa2 NP_076481.1 Rattus norvegicus
GeneID:108079 Prkaa2 NP_835279.1 Mus musculus
GeneID:181727 aak-2 NP_510711.2 Caenorhabditis elegans
GeneID:429110 PRKAA2 NP_001034694.1 Gallus gallus
GeneID:489571 PRKAA2 XP_546691.2 Canis lupus familiaris
GeneID:538954 PRKAA2 XP_583885.3 Bos taurus
GeneID:572074 LOC572074 XP_700831.3 Danio rerio
GeneID:741802 PRKAA2 XP_001144587.1 Pan troglodytes
GeneID:852088 SNF1 NP_010765.1 Saccharomyces cerevisiae
GeneID:1273276 AgaP_AGAP002686 XP_312237.2 Anopheles gambiae
GeneID:2539109 ssp2 NP_588376.1 Schizosaccharomyces pombe
GeneID:2675217 MGG_00803 XP_368441.2 Magnaporthe grisea
GeneID:2896802 KLLA0A03806g XP_451166.1 Kluyveromyces lactis
GeneID:4332495 Os03g0289100 NP_001049790.1 Oryza sativa
GeneID:4345873 Os08g0484600 NP_001062083.1 Oryza sativa
GeneID:4620813 AGOS_AEL230W NP_984631.1 Eremothecium gossypii

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005524 Function ATP binding
GO:0005515 Function protein binding
GO:0004672 Function protein kinase activity
GO:0004674 Function protein serine/threonine kinase activity
GO:0004713 Function protein tyrosine kinase activity
GO:0008340 Process determination of adult life span
GO:0006468 Process protein amino acid phosphorylation

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001029697 NP_001024868
2 NM_078309 NP_510710
3 NM_078310 NP_510711

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
icd-1 aak-2 / icd-1 Two-hybrid Li S (2004)
N/A aak-2 / N/A Two-hybrid Li S (2004)
nhr-2 aak-2 / nhr-2 Two-hybrid Li S (2004)
nhr-6 aak-2 / nhr-6 Two-hybrid Li S (2004)
unc-42 aak-2 / unc-42 Two-hybrid Li S (2004)
Y65B4BR.5 aak-2 / Y65B4BR.5 Two-hybrid Li S (2004)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Lee H, et al. (2008) "The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior." J Biol Chem. 283(22):14988-14993. PMID:18408008
  2. [ + ] Schulz TJ, et al. (2007) "Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress." Cell Metab. 6(4):280-293. PMID:17908557
  3. [ + ] Curtis R, et al. (2006) "Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways." Aging Cell. 5(2):119-126. PMID:16626391
  4. [ + ] Li S, et al. (2004) "A map of the interactome network of the metazoan C. elegans." Science. 303(5657):540-543. PMID:14704431
  5. [ + ] Mulder NJ, et al. (2003) "The InterPro Database, 2003 brings increased coverage and new features." Nucleic Acids Res. 31(1):315-318. PMID:12520011
  6. [ + ] Camon E, et al. (2003) "The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro." Genome Res. 13(4):662-672. PMID:12654719