Abcc4 | GeneID:170924 | Rattus norvegicus

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 170924 Official Symbol Abcc4
Locus N/A Gene Type protein-coding
Synonyms Mrp4
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Chromosome 15q24
Also Known As ABC-tranporter; ATP-binding cassette protein C4; multidrug resistance-associated protein 4
Summary ATP-binding cassette (ABC) multiple drug resistance protein (MRP) that mediates reduced glutatione release from hepatocytes into blood by cotransport with monoanionic bile salts [RGD]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 74563

ID Symbol Protein Species
GeneID:10257 ABCC4 NP_005836.2 Homo sapiens
GeneID:35163 CG31792 NP_724148.1 Drosophila melanogaster
GeneID:47905 l(2)03659 NP_610482.2 Drosophila melanogaster
GeneID:170924 Abcc4 NP_596902.1 Rattus norvegicus
GeneID:180691 mrp-6 NP_508710.2 Caenorhabditis elegans
GeneID:239273 Abcc4 NP_001028508.1 Mus musculus
GeneID:368620 abcc4 NP_001007039.1 Danio rerio
GeneID:418791 ABCC4 NP_001025990.1 Gallus gallus
GeneID:452625 ABCC4 XP_001137006.1 Pan troglodytes
GeneID:485523 ABCC4 XP_542642.2 Canis lupus familiaris
GeneID:515333 ABCC4 XP_593336.2 Bos taurus
GeneID:820496 ATMRP3 NP_187915.1 Arabidopsis thaliana
GeneID:820497 ATMRP8 NP_187916.3 Arabidopsis thaliana
GeneID:820498 ATMRP7 NP_187917.3 Arabidopsis thaliana
GeneID:4327122 Os01g0173900 NP_001042159.1 Oryza sativa


[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab32550 MRP4 antibody (ab32550); Rabbit polyclonal to MRP4

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0016323 Component basolateral plasma membrane
GO:0016021 Component integral to membrane
GO:0016020 Component membrane
GO:0005624 Component membrane fraction
GO:0005886 Component plasma membrane
GO:0031088 Component platelet dense granule membrane
GO:0016887 Function ATPase activity
GO:0042626 Function ATPase activity, coupled to transmembrane movement of substances
GO:0005524 Function ATP binding
GO:0005254 Function chloride channel activity
GO:0003674 Function molecular_function
GO:0000166 Function nucleotide binding
GO:0006811 Process ion transport
GO:0048661 Process positive regulation of smooth muscle cell proliferation
GO:0042493 Process response to drug
GO:0014070 Process response to organic cyclic substance
GO:0010243 Process response to organic nitrogen
GO:0010033 Process response to organic substance

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_133411  UCSC Browser NP_596902

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

AAK55412   AAQ10411   AAS78928   AAS78929   NP_596902   Q59DL1   Q6QMG5   Q6QMG6   Q91Y23  

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Roberts LM, et al. (2008) "Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation." Neuroscience. 155(2):423-438. PMID:18619525
  2. [ + ] Merrell MD, et al. (2008) "Induction of drug metabolism enzymes and transporters by oltipraz in rats." J Biochem Mol Toxicol. 22(2):128-135. PMID:18418891
  3. [ + ] Sassi Y, et al. (2008) "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation." J Clin Invest. 118(8):2747-2757. PMID:18636120
  4. [ + ] Okumura H, et al. (2007) "Change of drug excretory pathway by CCl4-induced liver dysfunction in rat." Biochem Pharmacol. 74(3):488-495. PMID:17544377
  5. [ + ] Smeets PH, et al. (2004) "Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter." J Am Soc Nephrol. 15(11):2828-2835. PMID:15504935
  6. [ + ] Denk GU, et al. (2004) "Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat." J Hepatol. 40(4):585-591. PMID:15030973
  7. [ + ] Chen C, et al. (2004) "Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility." Biochem Biophys Res Commun. 317(1):46-53. PMID:15047146
  8. [ + ] Rius M, et al. (2003) "Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane." Hepatology. 38(2):374-384. PMID:12883481
  9. [ + ] van Aubel RA, et al. (2002) "The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP." J Am Soc Nephrol. 13(3):595-603. PMID:11856762