FRAT1 | GeneID:10023 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 10023 Official Symbol FRAT1
Locus RP11-452K12.1 Gene Type protein-coding
Synonyms FLJ97193
Full Name frequently rearranged in advanced T-cell lymphomas
Description frequently rearranged in advanced T-cell lymphomas
Chromosome 10q24.1
Also Known As GSK-3 binding protein FRAT1; OTTHUMP00000020201; OTTHUMP00000059391; proto-oncogene FRAT1
Summary The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 3999

ID Symbol Protein Species
GeneID:10023 FRAT1 NP_005470.2 Homo sapiens
GeneID:14296 Frat1 NP_032069.2 Mus musculus
GeneID:466169 FRAT1 XP_521571.1 Pan troglodytes
GeneID:505664 FRAT1 XP_581986.3 Bos taurus

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab2533 FRAT1 antibody (ab2533); Goat polyclonal to FRAT1
2 abcam ab70918 FRAT1 antibody - C-terminal (ab70918); Rabbit polyclonal to FRAT1 - C-terminal
3 abgent AP1436b FRAT1 Antibody (C-term); Purified Rabbit Polyclonal Antibody (Pab)
4 abgent AP1436c FRAT1 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab)
5 acris AP11408PU-N FRAT1 (Center); antibody Ab
6 acris AP11407PU-N FRAT1 (C-term); antibody Ab
7 scbt FRAT1 FRAT1 Antibody / FRAT1 Antibodies;

Exon, Intron and UTRs

Exon, Intron and UTRs of FRAT1 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of FRAT1 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0005737 Component cytoplasm
GO:0000578 Process embryonic axis specification
GO:0016055 Process Wnt receptor signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_005479  UCSC Browser NP_005470

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of FRAT1 mRNA
16788091
Dihydrotestosterone
  • Dihydrotestosterone results in increased expression of FRAT1 mRNA
16631469

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
DVL1 FRAT1 / DVL1 Affinity Capture-Western Li L (1999)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Wang Y, et al. (2008) "FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma." Int J Cancer. 123(3):561-568. PMID:18498136
  2. [ + ] Hagen T, et al. (2006) "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J Biol Chem. 281(46):35021-35029. PMID:16982607
  3. [ + ] Wang Y, et al. (2006) "Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours." Br J Cancer. 94(5):686-691. PMID:16479254
  4. [ + ] Deloukas P, et al. (2004) "The DNA sequence and comparative analysis of human chromosome 10." Nature. 429(6990):375-381. PMID:15164054
  5. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  6. [ + ] Hino S, et al. (2003) "Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin." J Biol Chem. 278(16):14066-14073. PMID:12556519
  7. [ + ] Khambata-Ford S, et al. (2003) "Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay." Genome Res. 13(7):1765-1774. PMID:12805274
  8. [ + ] Saitoh T, et al. (2002) "Molecular cloning and expression of proto-oncogene FRAT1 in human cancer." Int J Oncol. 20(4):785-789. PMID:11894125
  9. [ + ] Freemantle SJ, et al. (2002) "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2." Gene. 291(1-2):17-27. PMID:12095675
  10. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  11. [ + ] Bax B, et al. (2001) "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation." Structure. 9(12):1143-1152. PMID:11738041
  12. [ + ] Saitoh T, et al. (2001) "FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer." Int J Oncol. 19(2):311-315. PMID:11445844
  13. [ + ] Li L, et al. (1999) "Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1." EMBO J. 18(15):4233-4240. PMID:10428961
  14. [ + ] Jonkers J, et al. (1997) "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas." EMBO J. 16(3):441-450. PMID:9034327