ABI1 | GeneID:10006 | Homo sapiens

Gene Summary

[ - ] NCBI Entrez Gene

Gene ID 10006 Official Symbol ABI1
Locus RP13-16H11.4 Gene Type protein-coding
Synonyms ABI-1; E3B1; NAP1BP; SSH3BP; SSH3BP1
Full Name abl-interactor 1
Description abl-interactor 1
Chromosome 10p11.2
Also Known As Abelson interactor 1; Abl-interactor protein 1 long; OTTHUMP00000019352; OTTHUMP00000019355; eps8 binding protein; interactor protein AblBP4; nap1 binding protein; spectrin SH3 domain binding protein 1
Summary The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq]

Orthologs and Paralogs

[ - ] Homologs - NCBI's HomoloGene Group: 38053

ID Symbol Protein Species
GeneID:10006 ABI1 NP_005461.2 Homo sapiens
GeneID:11308 Abi1 NP_001070658.1 Mus musculus
GeneID:79249 Abi1 NP_077373.1 Rattus norvegicus
GeneID:420489 RCJMB04_25c5 XP_001233769.1 Gallus gallus
GeneID:450363 ABI1 XP_001159512.1 Pan troglodytes
GeneID:607247 ABI1 XP_849209.1 Canis lupus familiaris
GeneID:767738 zgc:153534 NP_001070175.1 Danio rerio

Antibodies

[ - ] Monoclonal and Polyclonal Antibodies

No. Provider Product No. Description
1 abcam ab11222 SSH3BP1 antibody [4E2] (ab11222); Mouse monoclonal [4E2] to SSH3BP1
2 abcam ab75264 SSH3BP1 antibody (ab75264); Rabbit polyclonal to SSH3BP1
3 abcam ab65828 SSH3BP1 antibody - Carboxyterminal end (ab65828); Rabbit polyclonal to SSH3BP1 - Carboxyterminal end
4 abcam ab72318 SSH3BP1 antibody (ab72318); Rabbit polyclonal to SSH3BP1
5 abcam ab62660 SSH3BP1 antibody (ab62660); Rabbit polyclonal to SSH3BP1
6 abcam ab72317 SSH3BP1 antibody (ab72317); Rabbit polyclonal to SSH3BP1
7 abcam ab55901 SSH3BP1 antibody - Carboxyterminal end (ab55901); Rabbit polyclonal to SSH3BP1 - Carboxyterminal end
8 abcam ab55834 SSH3BP1 (phospho Y435) antibody (ab55834); Rabbit polyclonal to SSH3BP1 (phospho Y435)
9 acris AP17861PU-N Abl interactor 1 N-term; antibody Ab
10 scbt ABI1 ABI1 Antibody / ABI1 Antibodies;
11 sigma A5106 Anti-ABI1 antibody produced in rabbit ;
12 sigma A5231 Anti-Abi1 (C-terminal) antibody produced in rabbit ;

Exon, Intron and UTRs

Exon, Intron and UTRs of ABI1 Gene Transcript Isoforms

CpG near TSS

CpG dinucleotides near Transcription Start Site of ABI1 Gene

Gene Classification

[ - ] Gene Ontology

IDCategoryGO Term
GO:0030054 Component cell junction
GO:0005737 Component cytoplasm
GO:0005856 Component cytoskeleton
GO:0005829 Component cytosol
GO:0005783 Component endoplasmic reticulum
GO:0030175 Component filopodium
GO:0030426 Component growth cone
GO:0005622 Component intracellular
GO:0030027 Component lamellipodium
GO:0005634 Component nucleus
GO:0005625 Component soluble fraction
GO:0045202 Component synapse
GO:0019717 Component synaptosome
GO:0008092 Function cytoskeletal protein binding
GO:0008285 Process negative regulation of cell proliferation
GO:0018108 Process peptidyl-tyrosine phosphorylation
GO:0007169 Process transmembrane receptor protein tyrosine kinase signaling pathway

RefSeq Isoforms

[ - ] RefSeq Annotation and UniProt Database

No. RefSeq RNA RefSeq Protein UniProt Equivalent
1 NM_001012750  UCSC Browser NP_001012768 A9Z1Y6   Q8IZP0  
2 NM_001012751  UCSC Browser NP_001012769 Q5T2R3   Q8IZP0  
3 NM_001012752  UCSC Browser NP_001012770 Q5T2R7   Q8IZP0  
4 NM_005470  UCSC Browser NP_005461 Q5T2R6   Q8IZP0  

Transcript Sequences

[ - ] Transcript Accession Number Cloud [ GenBank ]

Protein Sequences

[ - ] Protein Accession Number Cloud [ GenPept ]

Mutations and SNPs

[ - ] NCBI's dbSNP

Phenotypes

[ - ] Genes and Diseases - MIM at NCBI

Chemicals and Drugs

[ - ] Comparative Toxicogenomics Database from MDI Biological Lab

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Chemical and Interaction
Acetaminophen
  • Acetaminophen affects the expression of ABI1 mRNA
17562736
Ethinyl Estradiol
  • Ethinyl Estradiol affects the expression of ABI1 mRNA
17555576
Flavonoids
  • Flavonoids results in decreased expression of ABI1 mRNA
18035473
Genistein
  • Genistein results in increased expression of ABI1 mRNA
15256057

Gene and Diseases

[ - ] Gene and Diseases [Data source: CTD]

Curated [chemical–gene interactions|chemical–disease|gene–disease] data were retrieved from the Comparative Toxicogenomics Database (CTD), Mount Desert Island Biological Laboratory, Salisbury Cove, Maine. World Wide Web (URL: http://ctd.mdibl.org/). [Jan. 2009].
Disease Name Relationship PubMed
Breast Neoplasms inferred via Genistein 17200150, 16873071, 16541309
Carcinoma, Hepatocellular inferred via Genistein 16924424
Cardiovascular Diseases inferred via Genistein 16332659
Colonic Neoplasms inferred via Genistein 17182828
Diabetes Mellitus, Type 2 inferred via Genistein 16647724
Endometrial Hyperplasia inferred via Genistein 16402032
Glioblastoma inferred via Genistein 16598420
Liver Cirrhosis, Experimental inferred via Genistein 17823541
Mammary Neoplasms, Experimental inferred via Genistein 14578162, 12929590
Myocardial Infarction inferred via Genistein 17141266
Myocardial Reperfusion Injury inferred via Genistein 17141266
Osteoporosis, Postmenopausal inferred via Genistein 16169203
Prostatic Neoplasms inferred via Genistein 16925846, 15256057, 15378649
Inflammation inferred via Flavonoids 17296493
Acne Vulgaris inferred via Ethinyl Estradiol 17505938
Adenocarcinoma inferred via Ethinyl Estradiol 14692618
Arteriosclerosis inferred via Ethinyl Estradiol 11256880
Arthritis, Experimental inferred via Ethinyl Estradiol 15885639
Cholestasis inferred via Ethinyl Estradiol 17110522, 11677210, 15861022, 16105132, 17333356, 16919318, 17681005
Encephalomyelitis, Autoimmune, Experimental inferred via Ethinyl Estradiol 12538720
Fatty Liver inferred via Ethinyl Estradiol 15345470
Hypospadias inferred via Ethinyl Estradiol 16569931, 16945680
Infertility, Female inferred via Ethinyl Estradiol 12013081
Infertility, Male inferred via Ethinyl Estradiol 17937319
Panic Disorder inferred via Ethinyl Estradiol 11578682
Pruritus inferred via Ethinyl Estradiol 16919318, 15861022
Spermatocele inferred via Ethinyl Estradiol 16709447
Thrombophilia inferred via Ethinyl Estradiol 11994571
Thrombosis inferred via Ethinyl Estradiol 15669648
Uterine Neoplasms inferred via Ethinyl Estradiol 14692618
Venous Thrombosis inferred via Ethinyl Estradiol 15869587
Hepatitis, Toxic inferred via Acetaminophen 2444490, 17522070, 14986274, 16227642, 15968718, 16177239, 17562736, 16081117
Hyperalgesia inferred via Acetaminophen 16870215
Liver Failure, Acute inferred via Acetaminophen 16871587, 17185352
Pain inferred via Acetaminophen 16870215

Gene Interactions

[ - ] BioGRID Gene Product Interaction Database

Symbol Interaction Binary Experiment Source
ABL1 ABL1 / ABI1 Affinity Capture-Western Biesova Z (1997)
ABL1 ABI1 / ABL1 Reconstituted Complex Tani K (2003)
ABL1 ABI1 / ABL1 Reconstituted Complex Yamamoto A (2001)
ENAH ABI1 / ENAH Reconstituted Complex Tani K (2003)
ENAH ENAH / ABI1 Two-hybrid Tani K (2003)
EPS8 ABI1 / EPS8 Affinity Capture-Western Biesova Z (1997)
EPS8 EPS8 / ABI1 Affinity Capture-Western Biesova Z (1997)
EPS8 EPS8 / ABI1 Affinity Capture-Western Lanzetti L (2000)
EPS8 EPS8 / ABI1 Affinity Capture-Western Offenhauser N (2004)
EPS8 ABI1 / EPS8 Reconstituted Complex Biesova Z (1997)
EPS8L1 EPS8L1 / ABI1 Affinity Capture-Western Offenhauser N (2004)
EPS8L2 EPS8L2 / ABI1 Affinity Capture-Western Offenhauser N (2004)
EPS8L3 EPS8L3 / ABI1 Affinity Capture-Western Offenhauser N (2004)
NCK1 ABI1 / NCK1 Reconstituted Complex Yamamoto A (2001)
NCKAP1 NCKAP1 / ABI1 Affinity Capture-Western Yamamoto A (2001)
NCKAP1 NCKAP1 / ABI1 Two-hybrid Yamamoto A (2001)
SOS1 SOS1 / ABI1 Affinity Capture-Western Scita G (1999)
SOS1 SOS1 / ABI1 Reconstituted Complex Scita G (1999)

Transcript Cluster

[ - ] NCBI's UniGene

Selected Publications

[ - ] Gene-related publications indexed at PubMed

  1. [ + ] Ryu JR, et al. (2009) "Regulation of cell-cell adhesion by Abi/Diaphanous complexes." Mol Cell Biol. 29(7):1735-1748. PMID:19158278
  2. [ + ] Xiong X, et al. (2008) "Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1." Biochim Biophys Acta. 1783(5):737-747. PMID:18328268
  3. [ + ] Sun X, et al. (2008) "MT1-MMP as a downstream target of BCR-ABL/ABL interactor 1 signaling: polarized distribution and involvement in BCR-ABL-stimulated leukemic cell migration." Leukemia. 22(5):1053-1056. PMID:17943163
  4. [ + ] Carabeo RA, et al. (2007) "Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion." Cell Microbiol. 9(9):2278-2288. PMID:17501982
  5. [ + ] Wang C, et al. (2007) "Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion." Mol Cancer Res. 5(10):1031-1039. PMID:17951403
  6. [ + ] Olsen JV, et al. (2006) "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Cell. 127(3):635-648. PMID:17081983
  7. [ + ] Hirao N, et al. (2006) "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation." FEBS Lett. 580(27):6464-6470. PMID:17101133
  8. [ + ] Stuart JR, et al. (2006) "c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading." J Biol Chem. 281(42):31290-31297. PMID:16899465
  9. [ + ] Roffers-Agarwal J, et al. (2005) "Regulation of actin cytoskeleton architecture by Eps8 and Abi1." BMC Cell Biol. 6():36. PMID:16225669
  10. [ + ] Jenei V, et al. (2005) "E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor." Exp Cell Res. 310(2):463-473. PMID:16182283
  11. [ + ] Maruoka M, et al. (2005) "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases." FEBS Lett. 579(14):2986-2990. PMID:15893754
  12. [ + ] Bierne H, et al. (2005) "WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor." J Cell Sci. 118(Pt 7):1537-1547. PMID:15769844
  13. [ + ] Gomez TS, et al. (2005) "Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse." Nat Immunol. 6(3):261-270. PMID:15696170
  14. [ + ] Leng Y, et al. (2005) "Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation." Proc Natl Acad Sci U S A. 102(4):1098-1103. PMID:15657136
  15. [ + ] Gerhard DS, et al. (2004) "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14(10B):2121-2127. PMID:15489334
  16. [ + ] Offenhauser N, et al. (2004) "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway." Mol Biol Cell. 15(1):91-98. PMID:14565974
  17. [ + ] Deloukas P, et al. (2004) "The DNA sequence and comparative analysis of human chromosome 10." Nature. 429(6990):375-381. PMID:15164054
  18. [ + ] Lin TY, et al. (2004) "Abi enhances Abl-mediated CDC2 phosphorylation and inactivation." J Biomed Sci. 11(6):902-910. PMID:15591787
  19. [ + ] Innocenti M, et al. (2004) "Abi1 is essential for the formation and activation of a WAVE2 signalling complex." Nat Cell Biol. 6(4):319-327. PMID:15048123
  20. [ + ] Gu Y, et al. (2003) "Induction of colonic epithelial cell apoptosis by p47-dependent oxidants." FEBS Lett. 540(1-3):195-200. PMID:12681507
  21. [ + ] Salomon AR, et al. (2003) "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry." Proc Natl Acad Sci U S A. 100(2):443-448. PMID:12522270
  22. [ + ] Gevaert K, et al. (2003) "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Nat Biotechnol. 21(5):566-569. PMID:12665801
  23. [ + ] Tani K, et al. (2003) "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase." J Biol Chem. 278(24):21685-21692. PMID:12672821
  24. [ + ] Di Fiore PP, et al. (2002) "Eps8 in the midst of GTPases." Int J Biochem Cell Biol. 34(10):1178-1183. PMID:12127568
  25. [ + ] Morerio C, et al. (2002) "Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?" Cancer Genet Cytogenet. 139(1):57-59. PMID:12547160
  26. [ + ] Strausberg RL, et al. (2002) "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." Proc Natl Acad Sci U S A. 99(26):16899-16903. PMID:12477932
  27. [ + ] Ichigotani Y, et al. (2002) "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)." Int J Mol Med. 9(6):591-595. PMID:12011975
  28. [ + ] Ichigotani Y, et al. (2002) "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells." Cancer Res. 62(8):2215-2219. PMID:11956071
  29. [ + ] Yamamoto A, et al. (2001) "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease." Gene. 271(2):159-169. PMID:11418237
  30. [ + ] Cowan CA, et al. (2001) "The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals." Nature. 413(6852):174-179. PMID:11557983
  31. [ + ] Courtney KD, et al. (2000) "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system." Mol Cell Neurosci. 16(3):244-257. PMID:10995551
  32. [ + ] Lanzetti L, et al. (2000) "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5." Nature. 408(6810):374-377. PMID:11099046
  33. [ + ] Xu J, et al. (2000) "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells." J Cell Sci. 113 Pt 21():3805-3814. PMID:11034908
  34. [ + ] Fan PD, et al. (2000) "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases." Mol Cell Biol. 20(20):7591-7601. PMID:11003655
  35. [ + ] Scita G, et al. (1999) "EPS8 and E3B1 transduce signals from Ras to Rac." Nature. 401(6750):290-293. PMID:10499589
  36. [ + ] Taki T, et al. (1998) "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)." Blood. 92(4):1125-1130. PMID:9694699
  37. [ + ] Ziemnicka-Kotula D, et al. (1998) "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." J Biol Chem. 273(22):13681-13692. PMID:9593709
  38. [ + ] Biesova Z, et al. (1997) "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth." Oncogene. 14(2):233-241. PMID:9010225
  39. [ + ] Cardwell C, et al. (1976) "Student or worker? International Meeting of Student Nurses (European Group)." Nurs Mirror Midwives J. 143(19):38. PMID:1049958